John R. Lake – 1 July 1995

Salahuddin Syed Ahmed, Hiroyuki Muro, Masahiko Nishimura, Isao Kosugi, Yoshihiro Tsutsui, Haruyuki Shirasawa – 1 July 1995 – In systemic lupus erythematosus accompanied by the abnormal appearance of circulating immune complexes (ICs), Fcγ receptor (FcR)–mediated IC handling in macrophages including Kupffer cells has been shown previously. However, sinusoidal endothelial cells (SECs) largely ingest soluble immunoglobulin (Ig) G–ICs through FcRs.

Anna Mae Diehl, Shi Qi Yang, Ming Yin, Hui Zhi Lin, Steve Nelson, Greg Bagby – 1 July 1995 – Injury‐related cytokines, such as tumor necrosis factor–alpha (TNF), may preserve liver‐specific gene expression during the subsequent regenerative response by modulating the activity of transcription factors, including CCAAT/enhancer binding proteins (C/EBPs), which regulate differentiated gene expression in hepato‐cytes.

Anke Kretz‐Rommel, Urs A. Boelsterli – 1 July 1995 – To evaluate whether hepatocellular protein adducts of the nonsteroidal antiinflammatory drug diclofenac could elicit a specific cell‐mediated or antibody‐dependent immune response that eventually results in liver cell destruction, we developed a murine ex vivo/in vitro mixed lymphocyte hepatocyte culture (MLHC) model. C57BL/6 mice were immunized either with diclofenac conjugated to keyhole limpet hemocyanin (KLH) or with KLH alone.

James R. McConnell, Dean L. Antonson, Chin Siong Ong, Wei‐Kom Chu, Ira J. Fox, Thomas G. Heffron, Alan N. Langnas, Byers W. Shaw – 1 July 1995 – Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (<1>H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure.

David R. Gretch, Carlos E. Bacchi, Lawrence Corey, Corazon Dela Rosa, Richard R. Lesniewski, Kris Kowdley, Allen Gown, Indra Frank, James D. Perkins, Robert L. Carithers – 1 July 1995 – We report a prospective clinical and virological study of 18 patients undergoing orthotopic liver transplantation, selected because of hepatitis C virus (HCV) RNA positivity before transplantation. Nine of the 18 patients (50%) developed chronic active hepatitis (CAH) in liver allografts during the first year posttransplantation; hepatitis was first observed between 6 and 25 weeks post‐transplantation.

John J. Fung, Jorge Rakela, Antonio Pinna, Satoru Todo – 1 July 1995

Matthias Wettstein, Birgitta Noé, Dieter Häussinger – 1 July 1995 – The influence of endotoxin on the hepatic metabolism and elimination of <3>H‐leukotriene C4 (LTC4) and <3>H‐leukotriene E4 was studied in the single‐pass perfused rat liver. Endotoxin (4 mg/kg body mass) was injected intraperitoneally 8 to 10 hours before livers were isolated for perfusion. Tritiated leukotriene C4 and leukotriene E4 (10 nmol/L) were infused for 5 minutes, and metabolites in bile were determined by high‐pressure liquid chromatography.

Caroline A. Riely, Alexander S. Petrides – 1 July 1995

Paul J. Winwood, Detlef Schuppan, John P. Iredale, Choudhury A. Kawser, Andrew J. P. Docherty, Michael J. P. Arthur – 1 July 1995 – Release of 92‐kd type IV collagenase/gelatinase, also known as gelatinase B, by inflammatory and tumor cells is increasingly recognized and is believed to facilitate cellular migration across basement membranes. It has been implicated in the pathogenesis of many diseases, but little is known of its cellular origin(s) and function in liver.