Ion V. Deaciuc, Gregory J. Bagby, Charles H. Lang, Nebojsa Skrepnik, John J. Spitzer – 1 July 1993 – The purpose of this investigation was to examine the effect of gram‐negative bacterial lipopolysaccharide on hyaluronan concentration in blood plasma, hyaluronan removal from the blood and hyaluronan uptake by isolated, perfused rat liver. Intravenous administration of Escherichia coli lipopolysaccharide to rats markedly increased plasma hyaluronan concentration in a dose‐dependent manner.

Joel E. Lavine – 1 July 1993

John Krikorian – 1 July 1993

Hisatoyo Hiraoka, Shizuya Yamashita, Yuji Matsuzawa, Masaharu Kubo, Shuichi Nozaki, Naohiko Sakai, Ken‐Ichi Hirano, Sumio Kawata, Seiichiro Tarui – 1 July 1993 – Serum levels of high‐density lipoprotein cholesterol are often increased in patients with primary biliary cirrhosis. To elucidate the mechanism of the elevation of high‐density lipoprotein cholesterol levels in this disease, lipoprotein abnormalities were analyzed in 10 patients subdivided into two groups according to concentration of high‐density lipoprotein cholesterol.

Ana Maria Wielandt, Margarita Pizarro, Nancy Solis, Marco Arrese, Luigi Accatino – 1 July 1993 – The effects of obstructive cholestasis on the activity of alkaline phosphatase have been extensively studied in serum and liver tissue. However, very little is known about the activity of this enzyme in the postcholestatic condition after relief of the biliary obstruction. The purpose of this study has been to characterize alkaline phosphatase activity in serum, liver and bile in the postcholestatic period and to relate it to changes in bile acid secretory rate.

Ernst Stechemesser, Reinhild Klein, Peter A. Berg – 1 July 1993 – The isolation of a marker antigen from rat liver and pancreas tissue, which reacts with antibodies in a subtype of autoimmune hepatitis by complement fixation test, enzyme‐linked immunosorbent assay and Western blot, is described. The liver‐pancreas antigen could be detected in tissue from different human or animal organs, but liver and pancreas yielded the highest activity.

Andrea Fabbri, Giulio Marchesini, Giampaolo Bianchi, Elisabetta Bugianesi, Lucia Bortoluzzi, Marco Zol, Emilio Pis – 1 July 1993 – Glucagon exerts an up‐regulatory effect on hepatic nitrogen metabolism in healthy subjects, but its potential role in the presence of liver failure is uncertain.

Takeshi Seki, Kendo Kiyosawa, Masao Ota, Seiichi Furuta, Hirofumi Fukushima, Eiji Tanaka, Kaname Yoshizawa, Toshiko Kumagai, Nobuhisa Mizuki, Asako And, Hidetoshi Inok – 1 July 1993 – To investigate the relationship between distribution of human leukocyte antigen alleles and susceptibility to primary biliary cirrhosis among Japanese, we performed serological typing and human leukocyte antigen DP genotyping in 47 Japanese patients with primary biliary cirrhosis.

Christian Cortinovis, Fritz Klimek, Enrique Nogueira – 1 July 1993 – Adenylate cyclase activity was measured in microdissected samples from lyophilized cryostat sections of rat liver by means of an improved assay. Livers were obtained from adult Sprague‐Dawley rats fasted for 22 hr. Adenylate cyclase activities, basal and those elicited by various agents, were determined in dissected samples from periportal and pericentral regions of the classic liver lobule.

Katsuaki Tanaka, Konomi Mitsui, Manabu Morimoto, Kazushi Numata, Shuji Inoue, Yutaro Takamur, Makoto Masumura – 1 July 1993 – To evaluate the effect of acute viral hepatitis on hepatic arterial blood flow, we performed color Doppler sonography with point‐spectral analysis in 15 patients with acute viral hepatitis and compared the results with those in 15 normal volunteers. During the acute phase of hepatitis, the peak‐systolic and enddiastolic velocity of the hepatic artery were significantly larger than those in normal arteries (p <0.01).