Repression of hepatic δ‐aminolevulinate synthase by heme and metalloporphyrins: Relationship to inhibition of heme oxygenase

Edward E. Cable, Julia W. Cable, Herbert L. Bonkovsky – 1 July 1993 – Heme‐ and tin‐chelated metalloporphyrins are known to decrease the activity of hepatic δ‐aminolevulinate synthase, the rate‐controlling enzyme of heme synthesis. We performed experiments in primary chick embryo liver cells with tin‐, zinc‐ and copperchelated porphyrins to assess their effects on activities of δ‐aminolevulinate synthase induced by prior treatment of cells with glutethimide and ferric nitrilotriacetate.

Mitogenic effect of transforming growth factor‐β1 on human ito cells in culture: Evidence for mediation by endogenous platelet‐derived growth factor

Khin Maung Win, Frederic Charlotte, Ariane Mallat, Daniel Cherqui, Nadine Martin, Philippe Mavier, Anne‐Marie Preaux, Daniel Dhumeau, Jean Rosenbaum – 1 July 1993 – We assessed the effect of transforming growth factor‐β1 on the proliferation of human Ito cells. Ito cells in their myofibroblastlike phenotype were grown from explants of human liver and were characterized with electron microscopy and positive immunostaining for desmin and smooth muscle α‐actin.

Is the multidrug resistance an ATP channel?

Jorge J. Gumucio, Irwin M. Arias – 1 July 1993 – The multidrug resistance (mdr1) gene product, P‐glycoprotein, is responsible for the ATP‐dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increaed levels of the P‐glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane.

Quantification of hepatitis C virus by competitive reverse transcription—polymerase chain reaction: Increase of the virus in advanced liver disease

Naoya Kato, Osamu Yokosuka, Kazuhiko Hosoda, Yoshimi Ito, Masao Ohto, Masao Omata – 1 July 1993 – We developed a quantitative method of hepatitis C virus RNA by competitive reverse transcription–polymerase chain reaction. With this method, 36 patients with type C chronic liver disease were analyzed for the copy number of circulating hepatitis C virus in 50 μl of serum. The amounts of hepatitis C virus RNA ranged from 101 to 107 copies in the 36 patients.

Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function

Naoki Yamanaka, Eizo Okamoto, Eisuke Kawamura, Toshihiro Kato, Tsuyoshi Oriyama, Jiro Fujimoto, Kazutaka Furukawa, Tsuneo Tanaka, Fumihito Tomoda, Wataru Tanaka – 1 July 1993 – We compared liver volume and function kinetics after partial hepatectomy according to extent of resection and severity of coexisting liver disease in 57 adults with uneventful postoperative courses. Liver volume and massiveness of resection, or resection rate, were estimated on computed tomography.

Gram‐negative bacterial lipopolysaccharide impairs hyaluronan clearance in vivo and its uptake by the isolated, perfused rat liver

Ion V. Deaciuc, Gregory J. Bagby, Charles H. Lang, Nebojsa Skrepnik, John J. Spitzer – 1 July 1993 – The purpose of this investigation was to examine the effect of gram‐negative bacterial lipopolysaccharide on hyaluronan concentration in blood plasma, hyaluronan removal from the blood and hyaluronan uptake by isolated, perfused rat liver. Intravenous administration of Escherichia coli lipopolysaccharide to rats markedly increased plasma hyaluronan concentration in a dose‐dependent manner.

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