Is the multidrug resistance an ATP channel?

Jorge J. Gumucio, Irwin M. Arias – 1 July 1993 – The multidrug resistance (mdr1) gene product, P‐glycoprotein, is responsible for the ATP‐dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increaed levels of the P‐glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane.

Quantification of hepatitis C virus by competitive reverse transcription—polymerase chain reaction: Increase of the virus in advanced liver disease

Naoya Kato, Osamu Yokosuka, Kazuhiko Hosoda, Yoshimi Ito, Masao Ohto, Masao Omata – 1 July 1993 – We developed a quantitative method of hepatitis C virus RNA by competitive reverse transcription–polymerase chain reaction. With this method, 36 patients with type C chronic liver disease were analyzed for the copy number of circulating hepatitis C virus in 50 μl of serum. The amounts of hepatitis C virus RNA ranged from 101 to 107 copies in the 36 patients.

Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function

Naoki Yamanaka, Eizo Okamoto, Eisuke Kawamura, Toshihiro Kato, Tsuyoshi Oriyama, Jiro Fujimoto, Kazutaka Furukawa, Tsuneo Tanaka, Fumihito Tomoda, Wataru Tanaka – 1 July 1993 – We compared liver volume and function kinetics after partial hepatectomy according to extent of resection and severity of coexisting liver disease in 57 adults with uneventful postoperative courses. Liver volume and massiveness of resection, or resection rate, were estimated on computed tomography.

Gram‐negative bacterial lipopolysaccharide impairs hyaluronan clearance in vivo and its uptake by the isolated, perfused rat liver

Ion V. Deaciuc, Gregory J. Bagby, Charles H. Lang, Nebojsa Skrepnik, John J. Spitzer – 1 July 1993 – The purpose of this investigation was to examine the effect of gram‐negative bacterial lipopolysaccharide on hyaluronan concentration in blood plasma, hyaluronan removal from the blood and hyaluronan uptake by isolated, perfused rat liver. Intravenous administration of Escherichia coli lipopolysaccharide to rats markedly increased plasma hyaluronan concentration in a dose‐dependent manner.

Decrease of hepatic triglyceride lipase levels and increase of cholesteryl ester transfer protein levels in patients with primary biliary cirrhosis: Relationship to abnormalities in high‐density lipoprotein

Hisatoyo Hiraoka, Shizuya Yamashita, Yuji Matsuzawa, Masaharu Kubo, Shuichi Nozaki, Naohiko Sakai, Ken‐Ichi Hirano, Sumio Kawata, Seiichiro Tarui – 1 July 1993 – Serum levels of high‐density lipoprotein cholesterol are often increased in patients with primary biliary cirrhosis. To elucidate the mechanism of the elevation of high‐density lipoprotein cholesterol levels in this disease, lipoprotein abnormalities were analyzed in 10 patients subdivided into two groups according to concentration of high‐density lipoprotein cholesterol.

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