Differential activation of transcription factors NF‐ϰB and AP‐1 in rat liver macrophages

Thuy‐Anh Tran‐Thi, Karl Decker, Patrick A. Baeuerle – 1 August 1995 – Liver macrophages (Kupffer cells) respond to many stimulations with the production of bioactive substances including cytokines, eicosanoids, and inorganic radicals. In this study the activation of transcription factors by substances inducing cytokine gene expression or superoxide formation in rat Kupffer cells was examined.

Peroxisome mosaicism in the livers of peroxisomal deficiency patients

Marc Espeel, Hanna Mandel, Florence Poggi, Jan A. M. Smeitink, Ronald J. A. Wanders, Ingrid Kerckaert, Rudolf B. H. Schutgens, Jean‐Marie Saudubray, Bwee‐Tien Poll‐The, Frank Roels – 1 August 1995 – Peroxisomal deficiency disorders, which are genetically transmitted, are assumed to be expressed in all cells, and the use of cultured skin fibroblasts for diagnosis and research is based on this assumption. We describe three patients with clinical, biochemical, and microscopic evidence of a peroxisomal disorder.

Effect of upright posture and physical exercise on endogenous neurohormonal systems in cirrhotic patients with sodium retention and normal supine plasma renin, aldosterone, and norepinephrine levels

Joan Saló, Angels Ginès, Luis Anibarro, Wladimiro Jiménez, Ramón Bataller, Joan Clària, Pere Ginès, Francisca Rirvera, Vicente Arroyo, Juan Rodés – 1 August 1995 – It is well known that sodium retention occurs in a significant proportion of patients with cirrhosis despite normal supine plasma levels of renin, aldosterone (ALDO), and norepinephrine (NE). The current study was performed to assess whether this subset of patients also present normal activity of the renin‐aldosterone and sympathetic nervous systems during upright posture in sitting position and moderate physical exercise.

Focal lymphocytic aggregates in chronic hepatitis C: Occurrence, immunohistochemical characterization, and relation to markers of autoimmunity

Maria Antonietta Freni, Domenica Artuso, Guido Gerken, Cesarina Spanti, Teresa Marafioti, Nunziata Alessi, Aldo Spadaro, Antonino Ajello, Oscar Ferrau – 1 August 1995 – Intrahepatic lymphocytic aggregates are observed in chronic hepatitis C as well as in autoimmune chronic hepatitis. Autoantibodies and autoimmune manifestations may occur in hepatitis C. It has been suggested that the lymphocytic aggregates play a role in the liver injury of chronic hepatitis C by an immune‐mediated mechanism.

Energy status in anoxic rat hepatocytes: Effects of isoflurane, solution composition, and hypothermia

Ben J. Howard, Roman Pohorecki, Gerald L. Becker, Dennis F. Landers – 1 July 1995 – Both cold and warm ischemia occur during liver transplantation. Hypothermia and Wisconsin solution preserve adenine nucleotide energy status, which is crucial to hepatic function and viability. The volatile anesthetic isoflurane has been shown to preserve energy status in anoxic isolated hepatocytes in warm Krebs solution. The present study examined isoflurane effects on energy status during incubation also in Wisconsin or Krebs‐plusadenosine solution at 37° or 4°.

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