Masaru Harada, Shotaro Sakisaka, Masao Yoshitake, Masahito Ohishi, Satoshi Itano, Satoshi Shakado, Yoshihiro Mimura, Kazunori Noguchi, Michio Sata, Hiroshi Yoshida, Kyuichi Tanikawa – 1 May 1995 – The process of receptor‐mediated endocytosis is common to a variety of species and cell types. One of the best characterized receptor‐ligand systems is the hepatocyte receptor for asialoglycoproteins. We investigated the morphological features of the uptake and intracellular transport of gold‐conjugated asialofetuin in isolated rat hepatocyte couplets.

Peter J. Friend – 1 May 1995

William M. Lee, Willis C. Maddrey – 1 May 1995

Robin D. Hughes, Roger Williams – 1 May 1995 – The initial clinical studies on artificial liver support were performed at King's College Hospital, London during the late 1970s. Initially using charcoal haemoperfusion, and subsequently resin haemoperfusion, and these studies culminated in a controlled clinical trial of charcoal haemoperfusion in which overall survival was high, but no statistically significant benefit was found.

Siddarth Ganguly, Shiv K. Sarin, Vivek Bhatia, Deepak Lahoti – 1 May 1995 – Portal hypertension diffusely affects the gastrointestinal tract. The frequency and profile of distinct colonic mucosal lesions (portal colopathy) and rectal varices (RV; veins >4 cm above the anal verge) is not well studied. Fifty consecutive patients with portal hypertension (25 with cirrhosis, 10 with noncirrhotic portal fibrosis [NCPF], and 15 with extrahepatic portal vein obstruction [EHPVO]) were assessed clinically and by upper and lower gastrointestinal (GI) endoscopy.

P. Aiden McCormick, Jason Chin, Lynda Greenslade, Stelios Karatapanis, Robert Dick, Neil McIntyre, Andrew K. Burroughs – 1 May 1995 – Octreotide is thought to reduce splanchnic and variceal blood flow with minimal effects on the systemic circulation in cirrhotic patients with portal hypertension. However, we noticed significant bradycardia in some patients immediately after administration of bolus doses of octreotide. Therefore, we investigated the effect of intravenous octreotide on systemic hemodynamics in 59 patients with cirrhosis.

Staffan Sahlin, Dagny Ståhlberg, Kurt Einarsson – 1 May 1995 – The objective of this study was to investigate possible pathogenetic factors for cholesterolosis. Liver tissue, gallbladder mucosa, and gallbladder bile were collected in patients with cholesterol gallstones (GS) (14 patients with and 14 patients without cholesterolosis) and gallstone‐free (GSF) subjects (11 with and 21 without cholesterolosis) undergoing cholecystectomy. In cholesterolosis, the gallbladder mucosa was characterized by a fivefold increase in esterified cholesterol and normal content of free cholesterol.

Jürgen Tudyka, Wolfgang Kratzer, Klaus Kuhn, Paul Janowitz, Johannes Georg Wechsler, Guido Adler – 1 May 1995 – Bile sampling without the risk of contamination by pancreatic and duodenal secretions and avoiding unpredictable influences of general anesthesia during biliary surgery on biliary analytics are feasible with percutaneous puncture of the gallbladder. In 207 patients with gallstones, gallbladder puncture was performed under local anesthesia with a 22‐gauge spinal needle under continuous real‐time ultrasound guidance.

1 May 1995

Ian R. Wanless, Julia J. Liu, Jagdish Butany – 1 May 1995 – The pathogenesis of congestive cirrhosis is generally thought to be a reaction of the hepatic stroma to hypoxia, pressure, or necrosis. This does not explain the poor correlation between symptoms and severity of fibrosis and the irregular distribution of fibrosis within the liver. We have observed healed hepatic vein (HV) thrombosis in patients with congestive heart failure (CHF).