Pierre Bedossa, Karl Houglum, Christian Trautwein, Axel Holstege, Mario Chojkier – 1 May 1994 – We have shown that lipid peroxidation stimulates collagen α1(I) gene transcription in cultured cells. Because increased lipid peroxidation and collagen production coexist in many hepatic disorders, including experimental carbon tetrachloride intoxication, we investigated whether lipid peroxidation modulates collagen gene expression in rats treated with carbon tetrachloride.

Akihito Tsubota, Kazuaki Chayama, Kenji Ikeda, Arase Yasuji, Isao Koida, Satoshi Saitoh, Michiyo Hashimoto, Satomi Iwasaki, Mariko Kobayashi, Kumada Hiromitsu – 1 May 1994 – To determine the patient‐dependent and virus‐related factors that may predict sustained response to interferon‐α therapy, we prospectively evaluated 60 consecutive patients with chronic hepatitis C who received a standardized treatment schedule of interferon‐α.

Herbert L. Bonkovsky, Robert E. Kane, Dean P. Jones, Raymond E. Galinsky, Barbara Banner – 1 May 1994 – A 67‐yr‐old man with chronic cardiopulmonary disease exhibited severe hepatic and moderately severe renal injury after short‐term ingestion of therapeutic doses of acetaminophen (1 to 3 gm/day for 3 days).

Philippe Podevin, Yvon Calmus, Annie Robert, Raoul Poupon, Gisele Cherqui – 1 May 1994 – Endogenous bile acids such as chenodeoxycholic acid have been shown to display a suppressive effect in vitro on mononuclear cell activation. We investigated the signal transduction pathway involved in the effect of chenodeoxycholic acid on monocyte procoagulant activity, a model of monocyte activation.

Kazuya Kato, Minoru Matsuda, Mitsuo Kusano, Kazuhiko Onodera, Junji Kato, Shinichi Kasai, Michio Mito, W. John B. Hodgson – 1 May 1994 – The effect of reticuloendothelial system activation on liver regeneration after 90% hepatectomy was investigated. OK‐432, a killed streptococcal preparation that increases reticuloendothelial system activity, was administered to rats before 90% partial hepatectomy. Pretreated rats showed marked improvement in long‐term survival: 87% (18 of 23) survived beyond 42 hr, compared with only 44.2% (24 of 52) of controls (p<0.05).

Elizabeth Ann Fagan – 1 May 1994

Neil O. Theise – 1 May 1994 – Distinguishing primary hepatocellular carcinoma (HCC) from metastatic carcinomas to the liver is often difficult, if not impossible, particularly in needle biopsy and fine‐needle aspiration specimens.

Betsy T. Kren, Amy L. Teel, Clifford J. Steer – 1 May 1994 – This study characterizes the mRNA expression of the retinoblastoma tumor suppressor gene in regenerating rat liver during 96 hr after 70% partial hepatectomy. A 960‐bp Bg1II‐OxaNI fragment of murine retinoblastoma cDNA was used to probe Northern blots of poly(A)+‐enriched RNA isolated from regenerating liver. Two species of retinoblastoma mRNA, 2.8 kb and 4.7 kb long, were identified in control liver and exhibited an intensity ratio of 5:1, respectively.

Douglas C. Hixson, Ronald A. Faris – 1 May 1994 – Following intrahepatic transplantation in adult syngeneic Fischer 344 rats, diploid cultured rat liver epithelial cells (WB‐F344), modified to carry the Eschericia coli β‐galactosidase reporter gene and/or the fluorescent membrane dye PKH26‐GL, integrate into hepatic plates and acquire the size and nuclear structure of mature hepatocytes.

1 May 1994