Effect of irradiation on hepatic natural killer cells

Karin Vanderkerken, Luc Bouwens, Peter Kuppen, Wilfried De Neve, Kit Van Den Berg, Marijke Baekeland, Eddie Wisse – 1 June 1994 – The rat liver contains a population of natural killer cells consisting of two morphologically and functionally different subsets, a low‐density and a high‐density fraction. In this work we describe the influence of low‐dose radiation on hepatic natural killer activity.

A multicenter study on the prognosis of fulminant viral hepatitis: Early prediction for liver transplantation

Yoshiyata Takahashi, Hiromitsu Kumada, Masaru Shimizu, Kyuichi Tanikawa, Ryukichi Kumashiro, Masao Omata, Toshiki Ehata, Takao Tsuji, Minoru Ukida, Mitsuru Yasunaga, Kiwamu Okita, Shunichi Sato, Toshihiko Takeuchi, Katsuhiko Tsukada, Hiroshi Obata, Etsuko Hashimoto, Yasuyuki Ohta, Kouji Tada, Yoshitane Kosaka, Koujiro Takase, Makoto Yoshiba, Kazuhiko Sekiyama, Takashi Kano, Yasuhiro Mizoguchi – 1 May 1994 – To determine the risk of death at an early stage of fulminant viral hepatitis, we created severity indexes drawn from clinical data on the day of development of encephalopathy in 128 pat

Nuclear ploidy of normal and neoplastic hepatocytes from woodchuck hepatitis virus–infected and uninfected woodchucks

John M. Cullen, David W. Linzey, Douglas H. Gebhard – 1 May 1994 – Flow cytometric analysis of the ploidy of normal and neoplastic hepatocyte nuclei obtained from adult woodchucks, a model of human hepadnavirus‐induced hepatocellular carcinoma, was performed. All 36 samples of nuclei from non‐neoplastic liver from woodchuck hepatitis virus–infected or uninfected liver were diploid, indicating that age‐related nuclear polyploidization does not occur in this species, unlike other rodents.

The fate of intravenously injected endotoxin in normal rats and in rats with liver failure

Akimasa Nakao, Shigemi Taki, Motoshi Yasui, Yasunori Kimura, Toshiaki Nonami, Akio Harada, Hiroshi Takagi – 1 May 1994 – The elimination of endotoxin from the blood was studied in rats with D‐galactosamine–induced liver failure and in normal controls after intravenous injection of various doses of endotoxin. Endotoxin was found to localize in liver tissue by immunohistochemical staining with factor C, which is derived from amebocyte lysate of the horseshoe crab and which reacts specifically with endotoxin.

Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?

Pierre Bedossa, Karl Houglum, Christian Trautwein, Axel Holstege, Mario Chojkier – 1 May 1994 – We have shown that lipid peroxidation stimulates collagen α1(I) gene transcription in cultured cells. Because increased lipid peroxidation and collagen production coexist in many hepatic disorders, including experimental carbon tetrachloride intoxication, we investigated whether lipid peroxidation modulates collagen gene expression in rats treated with carbon tetrachloride.

Factors predictive of response to interferon‐α therapy in hepatitis C virus infection

Akihito Tsubota, Kazuaki Chayama, Kenji Ikeda, Arase Yasuji, Isao Koida, Satoshi Saitoh, Michiyo Hashimoto, Satomi Iwasaki, Mariko Kobayashi, Kumada Hiromitsu – 1 May 1994 – To determine the patient‐dependent and virus‐related factors that may predict sustained response to interferon‐α therapy, we prospectively evaluated 60 consecutive patients with chronic hepatitis C who received a standardized treatment schedule of interferon‐α.

Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: Evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency

Herbert L. Bonkovsky, Robert E. Kane, Dean P. Jones, Raymond E. Galinsky, Barbara Banner – 1 May 1994 – A 67‐yr‐old man with chronic cardiopulmonary disease exhibited severe hepatic and moderately severe renal injury after short‐term ingestion of therapeutic doses of acetaminophen (1 to 3 gm/day for 3 days).

Inhibition of procoagulant activity of human monocytes by chenodeoxycholic acid: Involvement of protein kinase C

Philippe Podevin, Yvon Calmus, Annie Robert, Raoul Poupon, Gisele Cherqui – 1 May 1994 – Endogenous bile acids such as chenodeoxycholic acid have been shown to display a suppressive effect in vitro on mononuclear cell activation. We investigated the signal transduction pathway involved in the effect of chenodeoxycholic acid on monocyte procoagulant activity, a model of monocyte activation.

The immunostimulant OK‐432 enhances liver regeneration after 90% hepatectomy in rats

Kazuya Kato, Minoru Matsuda, Mitsuo Kusano, Kazuhiko Onodera, Junji Kato, Shinichi Kasai, Michio Mito, W. John B. Hodgson – 1 May 1994 – The effect of reticuloendothelial system activation on liver regeneration after 90% hepatectomy was investigated. OK‐432, a killed streptococcal preparation that increases reticuloendothelial system activity, was administered to rats before 90% partial hepatectomy. Pretreated rats showed marked improvement in long‐term survival: 87% (18 of 23) survived beyond 42 hr, compared with only 44.2% (24 of 52) of controls (p<0.05).

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