Shoji Kubo, Tom Rodriguez, Mark S. Roh, Caroline Oyedeji, Marvin M. Romsdahl, Kenji Nishioka – 1 April 1994 – Tuftsin (Thr‐Lys‐Pro‐Arg) is a natural immunomodulating peptide. We have investigated for the presence of a specific tuftsin receptor on murine Kupffer cells using fluorescein‐labeled tuftsin, which retains full biological activity. After incubation with fluorescein‐labeled tuftsin, Kupffer cells displayed clear binding of this compound on the plasma membrane. Excess tuftsin inhibited this binding, indicating the presence of specific tuftsin receptors on the Kupffer cells.

Ling Chen, Gerard J. Davis, David W. Crabb, Lawrence Lumeng – 1 April 1994 – Many hepatocyte‐specific genes are expressed heterogeneously in the liver lobule depending on the location of the hepatocytes in relation to the inflow or outflow of portal blood (i.e., periportal or perivenous). For example, albumin is expressed in all hepatocytes but more so in the periportal zone, cytochrome P‐450IIE1 is exclusively expressed in the perivenous zone and glutamine synthetase is limited to one or two cell layers next to the terminal hepatic venule.

Kenji Takenaka, Eisuke Adachi, Takashi Nishizaki, Kaichiro Hiroshige, Toshihiko Ikeda, Masazumi Tsuneyoshi, Keizo Sugimachi – 1 April 1994 – To assess the features of multicentric occurrence in hepatocellular carcinoma, we analyzed 10 of 72 patients (14%) who had undergone hepatic resection for hepatocellular carcinoma from May 1989 to October 1992 both clinically and pathologically.

Raymond S. Koff – 1 April 1994

Goshi Shiota, Timothy C. Wang, Toshikazu Nakamura, Emmett V. Schmidt – 1 April 1994 – Attention has recently been focused on hepatocyte growth factor as a major candidate factor in liver regeneration because it is the most potent known mitogen for hepatocytes in vitro. However, hepatocyte growth factor also displays diverse activities in vitro as scatter factor, as an epithelial morphogen, as a pluripotent mitogen and as a growth inhibitor.

William J. Sandborn, J. Eileen Hay, Michael K. Porayko, Gregory J. Gores, Jeffery L. Steers, Ruud A. F. Krom, Russell H. Wiesner – 1 April 1994 – Twelve consecutive liver transplant recipients with stable allograft function and cyclosporine nephrotoxicity were subjected to cyclosporine withdrawal in an attempt to halt and possibly reverse renal damage.

Elizabeth C. Jazwinska, June W. Halliday, Lawrie W. Powell – 1 April 1994 – Hereditary Hemochromatosis (HFE) is one of the most common inherited disorders with an estimated frequency of homozygous patients of 0.002‐0.0045. The disease is characterized by increased intestinal iron absorption and progressive iron overload. Affected subjects show clinical symptoms of parenchymal organ damage after the third‐fourth decade of life and have a 200‐fold increased risk of developing hepatocellular carcinoma.

Hideaki Enzan, Hiromi Himeno, Shinichi Iwamura, Saburo Onishi, Toshiji Saibara, Yasutake Yamamoto, Hiroshi Hara – 1 April 1994 – The purpose of this study is to clarify the morphological characteristics and functional significance of the perisinusoidal stromal cells in hepatocellular carcinoma. The liver specimens surgically resected from 24 patients with hepatocellular carcinoma were studied by electron microscopy and immunohistochemistry using monoclonal antibodies against α‐smooth muscle actin, vimentin and desmin.

1 April 1994

Khay‐Lin Teoh, Ian R. Mackay, Merrill J. Rowley, Shelley P. M. Fussey – 1 April 1994 – Primary biliary cirrhosis is a chronic autoimmune disease in which serum autoantibodies against the mitochondrial 2‐oxo acid dehydrogenase enzyme complexes (M2 antibodies) are regularly present. Molecular mimicry of host proteins by bacterial counterparts is a suggested explanation for the origin of these autoantibodies.