Philippe Podevin, Yvon Calmus, Annie Robert, Raoul Poupon, Gisele Cherqui – 1 May 1994 – Endogenous bile acids such as chenodeoxycholic acid have been shown to display a suppressive effect in vitro on mononuclear cell activation. We investigated the signal transduction pathway involved in the effect of chenodeoxycholic acid on monocyte procoagulant activity, a model of monocyte activation.

Kazuya Kato, Minoru Matsuda, Mitsuo Kusano, Kazuhiko Onodera, Junji Kato, Shinichi Kasai, Michio Mito, W. John B. Hodgson – 1 May 1994 – The effect of reticuloendothelial system activation on liver regeneration after 90% hepatectomy was investigated. OK‐432, a killed streptococcal preparation that increases reticuloendothelial system activity, was administered to rats before 90% partial hepatectomy. Pretreated rats showed marked improvement in long‐term survival: 87% (18 of 23) survived beyond 42 hr, compared with only 44.2% (24 of 52) of controls (p<0.05).

Elizabeth Ann Fagan – 1 May 1994

Neil O. Theise – 1 May 1994 – Distinguishing primary hepatocellular carcinoma (HCC) from metastatic carcinomas to the liver is often difficult, if not impossible, particularly in needle biopsy and fine‐needle aspiration specimens.

Betsy T. Kren, Amy L. Teel, Clifford J. Steer – 1 May 1994 – This study characterizes the mRNA expression of the retinoblastoma tumor suppressor gene in regenerating rat liver during 96 hr after 70% partial hepatectomy. A 960‐bp Bg1II‐OxaNI fragment of murine retinoblastoma cDNA was used to probe Northern blots of poly(A)+‐enriched RNA isolated from regenerating liver. Two species of retinoblastoma mRNA, 2.8 kb and 4.7 kb long, were identified in control liver and exhibited an intensity ratio of 5:1, respectively.

Douglas C. Hixson, Ronald A. Faris – 1 May 1994 – Following intrahepatic transplantation in adult syngeneic Fischer 344 rats, diploid cultured rat liver epithelial cells (WB‐F344), modified to carry the Eschericia coli β‐galactosidase reporter gene and/or the fluorescent membrane dye PKH26‐GL, integrate into hepatic plates and acquire the size and nuclear structure of mature hepatocytes.

1 May 1994

1 May 1994

Akira Iizuka, Tatsuro Watanabe, Toshiyuki Kubo, Masahiro Yamamoto, Kazuo Ogawa, Tetsuo Ohkuma, Akira Kaji – 1 May 1994 – We investigated effects of various DNAs on duck hepatitis B virus replication in vivo. One‐day‐old ducks were infected intravenously with DHBV. Various DNAs were then injected intravenously, and duck hepatitis B virus levels were followed for up to 20 days after the inoculation.

E. Jenny Heathcote, Karen Cauch‐Dudek, Valery Walker, Robert J. Bailey, Laurence M. Blendis, Cameron N. Ghent, Pina Michieletti, Gerald Y. Minuk, S. Chris Pappas, Linda J. Scully, Urs P. Steinbrecher, Lloyd R. Sutherland, C. Noel Williams, Helga Witt‐Sullivan, Lawrence J. Worobetz, Ruth A. Milner, Ian R. Wanless – 1 May 1994 – Ursodeoxycholic acid, a dihydroxyl bile acid normally present in human beings in minimal amounts, becomes incorporated into the bile salt pool when taken orally. In cholestasis, bile acids are retained in the liver and are hepatotoxic.