Howard M. Shulman, Lloyd B. Fisher, H. Gary Schoch, Kevin W. Henne, George B. McDonald – 1 May 1994 – We evaluated the relationship between the signs and symptoms of the clinical syndrome called venocclusive disease of the liver after bone marrow transplantation and the histological findings in 76 patients who later came to autopsy. Coded necropsy liver was scored for individual histological features that were correlated with prospectively assessed clinical features that the patients had exhibited during life.

Jesús Villanueva, Carol J. Chandler, Nell Shimasaki, Anna B. Tang, Manabu Nakamura, Stephen D. Phinney, Charles H. Halsted – 1 May 1994 – The micropig model of chronic alcoholism was used to study the relationship of lipid composition and physical properties in three different tissue membranes from the same animals. Ethanol feeding reduced membrane anisotropy, as measured with the diphenylhexatriene probe, in liver plasma and kidney brush‐border membranes but not in jejunal brushborder membranes.

Haruki Yamada, Gotaro Toda, Makoto Yoshiba, Naoaki Hashimoto, Yusei Ikeda, Hiroshi Mitsui, Kiyoshi Kurokawa, Fumio Sugata, Robin D. Hughes, Roger Williams – 1 May 1994 – Sera and ultrafiltrates (relative molecular mass<10,000 Da) from patients with fulminant liver failure inhibit hepatocyte DNA synthesis in vivo.

Hari S. Conjeevaram, Alexander Nagle, Andrew Katz, Kristine Kaminsky‐Russ, Arthur J. McCullough, Kevin D. Mullen – 1 May 1994 – The portacaval shunt rat is often used as a model of human portal‐systemic encephalopathy, but its relevance to human portal‐systemic encephalopathy remains uncertain. Specifically, it has not been demonstrated that the behavioral changes seen in this model respond to measures known to improve portal‐systemic encephalopathy in human subjects.

Ramon Gomis, Josefa Fernández‐Alvarez, Pilar Pizcueta, Mercedes Fernández, Roser Casamitjana, Jaume Bosch, Joan Rodés – 1 May 1994 – Increased circulating insulin and glucagon levels are a common observation in patients with cirrhosis, as well as in portal hypertensive models. Hyperinsulinemia and hyperglucagonemia may be caused either by increased beta‐ and alpha‐cell secretion or by defective hepatic clearance of these hormones.

Stephan Krähenbühl, Christine Talos, Jürg Reichen – 1 May 1994 – Hepatic metabolism of fatty acids is impaired in experimental animals with long‐term bile duct ligation. To characterize the underlying defects, fatty acid metabolism was investigated in isolated hepatocytes and isolated liver mitochondria from rats subjected to long‐term bile duct ligation or sham surgery. After starvation for 24 hr, the plasma β‐hydroxy‐butyrate concentration was decreased in rats with bile duct ligation as compared with control rats.

Mark J. Czaja, Jun Xu, Yue Ju, Elaine Alt, Phyllis Schmiedeberg – 1 May 1994 – Endogenous lipopolysaccharide has been implicated as a cofactor in the hepatocellular injury and death resulting from toxic liver injury. To prevent this lipopolysaccharide‐induced injury and to further understand the mechanism of this effect, an anti‐lipopolysaccharide antibody was administered to rats in which toxic hepatocellular injury was induced. Rats were given the hepatotoxin galactosamine together with an isotypic control antibody B55 or the anti‐lipopolysaccharide antibody E5.

R. Paul Aftring, Mason W. Freeman – 1 April 1994 – We employed homologous recombination in embryonic stem cells to produce mice lacking functional LDL receptor genes. Homozygous male and female mice lacking LDL receptors (LDLR−/− mice) were viable and fertile. Total plasma cholesterol levels were twofold higher than those of wild‐type littermates, owing to a seven‐ to ninefold increase in intermediate density lipoproteins (IDL) and LDL without a significant change in HDL. Plasma triglyceride levels were normal.

Kazuhiko Koike, Kyoji Moriya, Shiro Iino, Hiroshi Yotsuyanagi, Yasuo Endo, Tatsuo Miyamura, Kiyoshi Kurokawa – 1 April 1994 – We studied the development of liver tumors in male HBx gene transgenic mice.

Makoto Yoshiba, Kazuhiko Dehara, Kazuaki Inoue, Hiroaki Okamoto, Makoto Mayumi – 1 April 1994 – To assess the contribution of hepatitis C virus to non‐A, non‐B fulminant hepatitis in Japan, we compared 10 major clinical features among 7 patients with type B fulminant hepatitis (type B group), 13 patients with non‐A, non‐B fulminant hepatitis with evidence of hepatitis C virus infection (type C group) and 10 patients without evidence of hepatitis C virus infection (NANB group).