Paola Loria, Marco Bertolotti, M. Teresa Cassinadri, Michele A. Dilengite, Mara Bozzoli, Francesca Carubbi, Mauro Concari, M. Eugenia Guicciardi, Nicola Carulli – 1 April 1994 – To test whether de novo synthesis of cholesterol is a limiting factor for bile acid synthesis, we studied the acute effect of simvastatin, an inhibitor of HMG–coenzyme A reductase (the limiting step of cholesterol synthesis) on bile acid synthesis and biliary lipid secretion in subjects with interrupted enterohepatic circulation.

Masafumi Naito, Norio Hayashi, Hideki Hagiwara, Naoki Hiramatsu, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 April 1994 – We studied hepatitis C virus carriers with normal liver function to evaluate the histological features of their livers and the replicative levels of hepatitis C virus. Liver biopsies were performed in 22 hepatitis C virus carriers with persistently normal ALT levels.

Jean‐Michel Pawlotsky, Mustapha Ben Yahia, Chantal Andre, Marie‐Catherine Voisin, Liliane Intrator, Françoise Roudot‐Thoraval, Lionel Deforges, Christophe Duvoux, Elie‐Serge Zafrani, Jean Duval, Daniel Dhumeaux – 1 April 1994 – Hepatitis C virus–related chronic hepatitis may be associated with various immunological disorders.

Luigi Pagliaro, Antonio Craxí, Calogero Cammaá, Fabio Tiné, Vito Di Marco, Oreste Lo Iacono, Piero Almasio – 1 April 1994 – To identify predictors of short‐term and sustained ALT normalization after interferon treatment in adult patients with chronic hepatitis C, we performed a metanalysis of individual patients' data, with construction and cross‐validation of a prediction rule, in 361 patients from two randomized trials.

Raymond S. Koff – 1 April 1994

Dominique Deschamps, Virginie DeBeco, Cecile Fisch, Bernard Fromenty, Andre Guillouzo, Dominique Pessayre – 1 April 1994 – In an attempt to better understand the mechanisms for pseudoalcoholic liver lesions in human beings, we determined the effects of perhexiline on mitochondrial functions in mice and rats. A first series of studies suggested that protonated perhexiline entered mouse mitochondria along the mitochondrial membrane potential.

William M. Pandak, Z. Reno Vlahcevic, Douglas M. Heuman, Kaye S. Redford, John Y. L. Chiang, Philip B. Hylemon – 1 April 1994 – Cholesterol 7α‐hydroxylase, the rate‐limiting enzyme in the bile acid synthesis pathway, is downregulated by taurocholate by way of negative feedback control at the level of gene transcription. The molecular basis of regulation of cholesterol 7α‐hydroxylase by other hydrophobic bile salts and under more physiological conditions is not known.

Samuel H. Sigal, Shlomo Brill, Lola M. Reid, Isabel Zvibel, Sanjeev Gupta, Douglas Hixson, Ronald Faris, Patricia A. Holst – 1 April 1994 – We developed methods for enriching fetal hepatoblasts by combining panning and multiparametric fluorescence‐activated cell sorting. In unpurified, dissociated fetal liver cell suspensions of embryonic age day 15, 3.2% ± 1.3% and 2.5% ± 0.7% cells expressed albumin and α‐fetoprotein, respectively. The remainder exhibited a hemopoietic, endothelial or stromal cell phenotype.

Hartmut Jaeschke, Anwar Farhood, C. Wayne Smith – 1 April 1994 – The role of complement as potential activator for tissue macrophages and neutrophils was investigated in an experimental model of endotoxin‐induced liver injury in male Fischer rats.

Mitchell L. Shiffman, Velimir A. Luketic, Arun J. Sanyal, P. Frederick Duckworth, Preston P. Purdum, Melissa J. Contos, A. Scott Mills, Leslie E. Edinboro, Alphonse Poklis – 1 April 1994 – Recent advances in the medical and surgical treatment of chronic hepatitis and cirrhosis have made it increasingly important to develop noninvasive tests of liver function.