1 April 1994

Hideaki Enzan, Hiromi Himeno, Shinichi Iwamura, Saburo Onishi, Toshiji Saibara, Yasutake Yamamoto, Hiroshi Hara – 1 April 1994 – The purpose of this study is to clarify the morphological characteristics and functional significance of the perisinusoidal stromal cells in hepatocellular carcinoma. The liver specimens surgically resected from 24 patients with hepatocellular carcinoma were studied by electron microscopy and immunohistochemistry using monoclonal antibodies against α‐smooth muscle actin, vimentin and desmin.

Elizabeth C. Jazwinska, June W. Halliday, Lawrie W. Powell – 1 April 1994 – Hereditary Hemochromatosis (HFE) is one of the most common inherited disorders with an estimated frequency of homozygous patients of 0.002‐0.0045. The disease is characterized by increased intestinal iron absorption and progressive iron overload. Affected subjects show clinical symptoms of parenchymal organ damage after the third‐fourth decade of life and have a 200‐fold increased risk of developing hepatocellular carcinoma.

William J. Sandborn, J. Eileen Hay, Michael K. Porayko, Gregory J. Gores, Jeffery L. Steers, Ruud A. F. Krom, Russell H. Wiesner – 1 April 1994 – Twelve consecutive liver transplant recipients with stable allograft function and cyclosporine nephrotoxicity were subjected to cyclosporine withdrawal in an attempt to halt and possibly reverse renal damage.

Goshi Shiota, Timothy C. Wang, Toshikazu Nakamura, Emmett V. Schmidt – 1 April 1994 – Attention has recently been focused on hepatocyte growth factor as a major candidate factor in liver regeneration because it is the most potent known mitogen for hepatocytes in vitro. However, hepatocyte growth factor also displays diverse activities in vitro as scatter factor, as an epithelial morphogen, as a pluripotent mitogen and as a growth inhibitor.

Raymond S. Koff – 1 April 1994

Kenji Takenaka, Eisuke Adachi, Takashi Nishizaki, Kaichiro Hiroshige, Toshihiko Ikeda, Masazumi Tsuneyoshi, Keizo Sugimachi – 1 April 1994 – To assess the features of multicentric occurrence in hepatocellular carcinoma, we analyzed 10 of 72 patients (14%) who had undergone hepatic resection for hepatocellular carcinoma from May 1989 to October 1992 both clinically and pathologically.

Ling Chen, Gerard J. Davis, David W. Crabb, Lawrence Lumeng – 1 April 1994 – Many hepatocyte‐specific genes are expressed heterogeneously in the liver lobule depending on the location of the hepatocytes in relation to the inflow or outflow of portal blood (i.e., periportal or perivenous). For example, albumin is expressed in all hepatocytes but more so in the periportal zone, cytochrome P‐450IIE1 is exclusively expressed in the perivenous zone and glutamine synthetase is limited to one or two cell layers next to the terminal hepatic venule.

Shoji Kubo, Tom Rodriguez, Mark S. Roh, Caroline Oyedeji, Marvin M. Romsdahl, Kenji Nishioka – 1 April 1994 – Tuftsin (Thr‐Lys‐Pro‐Arg) is a natural immunomodulating peptide. We have investigated for the presence of a specific tuftsin receptor on murine Kupffer cells using fluorescein‐labeled tuftsin, which retains full biological activity. After incubation with fluorescein‐labeled tuftsin, Kupffer cells displayed clear binding of this compound on the plasma membrane. Excess tuftsin inhibited this binding, indicating the presence of specific tuftsin receptors on the Kupffer cells.

William N. Katkov – 1 April 1994 – To compare octreotide with injection sclerotherapy in the treatment of acute variceal hemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotide (50 μg intravenous bolus plus 50 μg per hr intravenous infusion for 48 hr). At the end of the study period (48 hr), the octreotide group also had sclerotherapy to obliterate the varices.