Ling Chen, Gerard J. Davis, David W. Crabb, Lawrence Lumeng – 1 April 1994 – Many hepatocyte‐specific genes are expressed heterogeneously in the liver lobule depending on the location of the hepatocytes in relation to the inflow or outflow of portal blood (i.e., periportal or perivenous). For example, albumin is expressed in all hepatocytes but more so in the periportal zone, cytochrome P‐450IIE1 is exclusively expressed in the perivenous zone and glutamine synthetase is limited to one or two cell layers next to the terminal hepatic venule.

Shoji Kubo, Tom Rodriguez, Mark S. Roh, Caroline Oyedeji, Marvin M. Romsdahl, Kenji Nishioka – 1 April 1994 – Tuftsin (Thr‐Lys‐Pro‐Arg) is a natural immunomodulating peptide. We have investigated for the presence of a specific tuftsin receptor on murine Kupffer cells using fluorescein‐labeled tuftsin, which retains full biological activity. After incubation with fluorescein‐labeled tuftsin, Kupffer cells displayed clear binding of this compound on the plasma membrane. Excess tuftsin inhibited this binding, indicating the presence of specific tuftsin receptors on the Kupffer cells.

William N. Katkov – 1 April 1994 – To compare octreotide with injection sclerotherapy in the treatment of acute variceal hemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotide (50 μg intravenous bolus plus 50 μg per hr intravenous infusion for 48 hr). At the end of the study period (48 hr), the octreotide group also had sclerotherapy to obliterate the varices.

Hervé Bejanin, André Choury, Jacques Fritsch, Catherine Buffet, René Baumann – 1 April 1994

Maurizio D'Aquino, Lucio Michieletto, Diego Tempesta, Corrado Pipan – 1 April 1994

1 April 1994

Detlef Jakschies, Reinhardt Zachoval, Rainer Müller, Michael Manns, Klaus‐Ulrich Nolte, Heinz‐Kurt Hochkeppel, Michel‐Andre Horisberger, Helmuth Deicher, Peter Von Wussow – 1 April 1994 – The human MxA protein is a new specific marker for type I interferon activity both in vitro and in vivo.

Carole Oddoux, Gerd Grieninger – 1 March 1994 – In all vertebrate species studied, the complex, disulfide‐linked structure of fibrinogen is essentially the same: a hexamer assembled from three different subunits (Aα, Bß,γ)2. This study utilized species differences in fibrinogen subunit monomer pools to address the question of how these surplus subunit pools may affect the assembly process. We used a chicken model system in which Bß and γ‐subunits are present in excess, in contrast to the Aα and γ‐subunit surplus found in human model systems.

Antonello Pietrangelo, Rossana Gualdi, Giovanna Casalgrandi, Albert Geerts, Pieter de Bleser, Giuliana Montosi, Ezio Ventura – 1 March 1994 – In recent years, identifying the hepatic cell type responsible for collagen synthesis in experimental models of postnecrotic or inflammatory fibrosis has been the subject of active investigation. In primary iron overload states, however, hepatic fibrosis and cirrhosis occur without accompanying necroinflammatory phenomena.

Renée E. Poupon, Beverley Balkau, Jérôme Guéchot, François Heintzmann – 1 March 1994 – The aim of this study was to define factors predictive of the onset of the terminal phase, defined by hyperbilirubinemia or the occurrence of a severe clinical complication, in patients with primary biliary cirrhosis treated with ursodeoxycholic acid. The 97 primary biliary cirrhosis patients in this study participated in a 2‐yr clinical trial.