Timothy M. McCashland, Jeremiah P. Donovan, Andree Amelsberg, Steven S. Rossi, Alan F. Hofmann, Byers W. Shaw, Eamonn M. M. Quigley – 1 June 1994 – Bile acid metabolism and biliary secretion were characterized in the first 2 wk after orthotopic liver transplantation in 15 patients receiving cyclosporine and in five patients receiving FK 506. Analyses were performed on hepatic bile obtained by T‐tube drainage; values obtained were compared with literature values for bile samples obtained in patients who had undergone cholecystectomy.

Hirofumi Takahashi, Toshiji Saibara, Shinichi Iwamura, Akira Tomita, Takashi Maeda, Saburo Onishi, Yasutake Yamamoto, Hideaki Enzan – 1 June 1994 – The serum level of α‐L‐fucosidase activity has been suggested as a useful marker in the diagnosis of hepatocellular carcinoma, although the precise mechanism behind the elevation of this parameter has not been determined.

Leon J. Reinstein, Steven N. Lichtman, Robert T. Currin, Jian Wang, Ronald G. Thurman, John J. Lemasters – 1 June 1994 – In liver grafts that will fail as a result of storage injury, reperfusion activates Kupffer cells. Overproduction of tumor necrosis factor by activated Kupffer cells may cause primary graft nonfunction, multiple organ failure and, eventually, death of graft recipients. Carolina rinse solution, adenosine, nisoldipine, pentoxifylline and prostaglandin E1 reduce graft failure from storage/reperfusion injury.

Masayoshi Kobune, Yutaka Kohgo, Junji Kato, Etsu Miyazaki, Yoshiro Niitsu – 1 June 1994 – To explore a mechanism of interleukin (IL)‐6–induced hypoferremia in rats, iron metabolism was investigated both in vivo and in vitro. Recombinant IL‐6 was intraperitoneally administered to male Wistar rats and the serial change of parameters related to iron metabolism was examined. After administration of IL‐6, plasma IL‐6 concentration increased rapidly, reached its maximum in 1 hr and thereafter decreased quickly.

Arnold Kooij, Henry J. Schiller, Martin Schijns, Cornelis J. F. Van Noorden, Wilma M. Frederiks – 1 June 1994 – The aim of this study was to test whether conversion of xanthine dehydrogenase into xanthine oxidase as induced by fasting, ischemia of the liver or both is an in vivo process or only occurs in vitro in homogenates. For this purpose, the conversion rate of xanthine dehydrogenase into xanthine oxidase was studied in liver homogenates obtained from rats after normal feeding or 24 hr of fasting followed or not by 2 hr of ischemia of the liver.

Karin Vanderkerken, Luc Bouwens, Peter Kuppen, Wilfried De Neve, Kit Van Den Berg, Marijke Baekeland, Eddie Wisse – 1 June 1994 – The rat liver contains a population of natural killer cells consisting of two morphologically and functionally different subsets, a low‐density and a high‐density fraction. In this work we describe the influence of low‐dose radiation on hepatic natural killer activity.

Yoshiyata Takahashi, Hiromitsu Kumada, Masaru Shimizu, Kyuichi Tanikawa, Ryukichi Kumashiro, Masao Omata, Toshiki Ehata, Takao Tsuji, Minoru Ukida, Mitsuru Yasunaga, Kiwamu Okita, Shunichi Sato, Toshihiko Takeuchi, Katsuhiko Tsukada, Hiroshi Obata, Etsuko Hashimoto, Yasuyuki Ohta, Kouji Tada, Yoshitane Kosaka, Koujiro Takase, Makoto Yoshiba, Kazuhiko Sekiyama, Takashi Kano, Yasuhiro Mizoguchi – 1 May 1994 – To determine the risk of death at an early stage of fulminant viral hepatitis, we created severity indexes drawn from clinical data on the day of development of encephalopathy in 128 pat

John M. Cullen, David W. Linzey, Douglas H. Gebhard – 1 May 1994 – Flow cytometric analysis of the ploidy of normal and neoplastic hepatocyte nuclei obtained from adult woodchucks, a model of human hepadnavirus‐induced hepatocellular carcinoma, was performed. All 36 samples of nuclei from non‐neoplastic liver from woodchuck hepatitis virus–infected or uninfected liver were diploid, indicating that age‐related nuclear polyploidization does not occur in this species, unlike other rodents.

Akimasa Nakao, Shigemi Taki, Motoshi Yasui, Yasunori Kimura, Toshiaki Nonami, Akio Harada, Hiroshi Takagi – 1 May 1994 – The elimination of endotoxin from the blood was studied in rats with D‐galactosamine–induced liver failure and in normal controls after intravenous injection of various doses of endotoxin. Endotoxin was found to localize in liver tissue by immunohistochemical staining with factor C, which is derived from amebocyte lysate of the horseshoe crab and which reacts specifically with endotoxin.

Pierre Bedossa, Karl Houglum, Christian Trautwein, Axel Holstege, Mario Chojkier – 1 May 1994 – We have shown that lipid peroxidation stimulates collagen α1(I) gene transcription in cultured cells. Because increased lipid peroxidation and collagen production coexist in many hepatic disorders, including experimental carbon tetrachloride intoxication, we investigated whether lipid peroxidation modulates collagen gene expression in rats treated with carbon tetrachloride.