Akira Iizuka, Tatsuro Watanabe, Toshiyuki Kubo, Masahiro Yamamoto, Kazuo Ogawa, Tetsuo Ohkuma, Akira Kaji – 1 May 1994 – We investigated effects of various DNAs on duck hepatitis B virus replication in vivo. One‐day‐old ducks were infected intravenously with DHBV. Various DNAs were then injected intravenously, and duck hepatitis B virus levels were followed for up to 20 days after the inoculation.
1 May 1994
1 May 1994
Douglas C. Hixson, Ronald A. Faris – 1 May 1994 – Following intrahepatic transplantation in adult syngeneic Fischer 344 rats, diploid cultured rat liver epithelial cells (WB‐F344), modified to carry the Eschericia coli β‐galactosidase reporter gene and/or the fluorescent membrane dye PKH26‐GL, integrate into hepatic plates and acquire the size and nuclear structure of mature hepatocytes.
Betsy T. Kren, Amy L. Teel, Clifford J. Steer – 1 May 1994 – This study characterizes the mRNA expression of the retinoblastoma tumor suppressor gene in regenerating rat liver during 96 hr after 70% partial hepatectomy. A 960‐bp Bg1II‐OxaNI fragment of murine retinoblastoma cDNA was used to probe Northern blots of poly(A)+‐enriched RNA isolated from regenerating liver. Two species of retinoblastoma mRNA, 2.8 kb and 4.7 kb long, were identified in control liver and exhibited an intensity ratio of 5:1, respectively.
Neil O. Theise – 1 May 1994 – Distinguishing primary hepatocellular carcinoma (HCC) from metastatic carcinomas to the liver is often difficult, if not impossible, particularly in needle biopsy and fine‐needle aspiration specimens.
Elizabeth Ann Fagan – 1 May 1994
Kazuya Kato, Minoru Matsuda, Mitsuo Kusano, Kazuhiko Onodera, Junji Kato, Shinichi Kasai, Michio Mito, W. John B. Hodgson – 1 May 1994 – The effect of reticuloendothelial system activation on liver regeneration after 90% hepatectomy was investigated. OK‐432, a killed streptococcal preparation that increases reticuloendothelial system activity, was administered to rats before 90% partial hepatectomy. Pretreated rats showed marked improvement in long‐term survival: 87% (18 of 23) survived beyond 42 hr, compared with only 44.2% (24 of 52) of controls (p<0.05).
Philippe Podevin, Yvon Calmus, Annie Robert, Raoul Poupon, Gisele Cherqui – 1 May 1994 – Endogenous bile acids such as chenodeoxycholic acid have been shown to display a suppressive effect in vitro on mononuclear cell activation. We investigated the signal transduction pathway involved in the effect of chenodeoxycholic acid on monocyte procoagulant activity, a model of monocyte activation.
Herbert L. Bonkovsky, Robert E. Kane, Dean P. Jones, Raymond E. Galinsky, Barbara Banner – 1 May 1994 – A 67‐yr‐old man with chronic cardiopulmonary disease exhibited severe hepatic and moderately severe renal injury after short‐term ingestion of therapeutic doses of acetaminophen (1 to 3 gm/day for 3 days).