Immunohistochemical phenotyping of liver macrophages in normal and diseased human liver

Minoru Tomita, Kazuhide Yamamoto, Haruhiko Kobashi, Masaki Ohmoto, Takao Tsuji – 1 August 1994 – The phenotypical heterogeneity of human liver macrophages was analyzed with monoclonal antibodies that recognize antigens specific for the monocytemacrophage lineage. Most liver macrophages in normal and diseased liver were positive for CD68, whereas fewer matured macrophages were detected by 25–F9. Comparative staining of mirror sections revealed some to be doubly positive and others to be singly CD68 positive.

Renal duplex doppler ultrasonography: A noninvasive predictor of kidney dysfunction and hepatorenal failure in liver disease

Joel F. Platt, James H. Ellis, Jonathan M. Rubin, Robert M. Merion, Michael R. Lucey – 1 August 1994 – Hepatorenal failure, a well‐recognized complication of established liver disease, is characterized by early renal hemodynamic changes (vasoconstriction) before clinically recognized kidney disease. This renal vasoconstruction (increased renal vascular resistance) should be detectable noninvasively by Doppler ultrasonography.

AT long last: An animal model of Wilson's disease

Ronald J. Sokol – 1 August 1994 – The LEC rat is an inbred mutant strain with spontaneous hepatitis isolated from Long‐Evans rats. Since approximately 40% of LEC rats die of fulminant hepatitis, the rat serves an animal model for studying the pathogenesis and treatment of human fulminant hepatitis. The remaining 60% of LEC rats survive and develop chronic (prolonged) hepatitis and subsequently develop liver cancer.

The role of tumor necrosis factor‐α in acute endotoxin‐induced hepatotoxicity in ethanol‐fed rats

John Hansen, David L. Cherwitz, John I. Allen – 1 August 1994 – An in vivo model of ethanol ingestion in rats was used to examine tumor necrosis factor‐α production after intravenous injection with lipopolysaccharide or saline solution. Four groups of 125‐gm male Sprague‐Dawley rats were given one of the following four diets: liquid ethanol diet (ethanol, 36% of calories), liquid control diet, chow ad libitum or control liquid diet pair‐fed to match calories consumed by ethanol‐fed rats. After 6 wk of diet, all rats were injected with 1 mg/kg lipopolysaccharide or 0.9% saline.

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