Antonio Benedetti, Luca Marucci, Cristina Bassotti, Carlo Guidarelli, Anne Marie Jezequel – 1 July 1995 – The fungal metabolite Brefeldin A (BFA) has become a valuable tool to address mechanisms of membrane transport in eukaryotic cells. The aim of the study was to investigate the action of BFA on the endocytic and transcytotic pathways in the biliary epithelium. Intrahepatic bile ductules were isolated from rat liver by collagenase digestion and mechanical separation of biliary tree from parenchymal tissue.

1 July 1995

1 July 1995

Norman D. Grace – 1 July 1995

Russell H. Wiesner, Ruud A. F. Krom – 1 July 1995

Janine S. McMillan, Tim Shaw, Peter W. Angus, Stephen A. Locarnini – 1 July 1995 – Hepatitis B virus (HBV) DNA‐transfected hepatoma cells were incubated with the immunosuppressive agents prednisolone, azathioprine, and cyclosporin A (CsA) and the antiviral agents ganciclovir and foscarnet to investigate the effects of these compounds on HBV replication. Prednisolone and azathioprine increased in‐tracellular viral DNA and RNA levels approximately twofold and fourfold, respectively. Treatment with CsA did not alter the levels of viral RNA or DNA.

Susan Kennedy, Steve Rettinger, M. Wayne Flye, Katherine Parker Ponder – 1 July 1995 – One hypothesis is that postnatal liver growth involves replication of mature hepatocytes, which have an unlimited proliferative potential. An alternative viewpoint is that only certain periportal cells can replicate extensively and that daughter cells stream slowly from the periportal to the pericentral region of the liver. Transgenic mice expressing the beta‐galactosidase (β‐gal) gene from the human α1 antitrypsin promoter were used to examine the proliferative potential of hepatocytes.

Alan P. Venook, Linda D. Ferrell, John P. Roberts, Jean Emond, John W. Frye, Ernest Ring, Nancy L. Ascher, John R.

Eugene R. Schiff – 1 July 1995

Karin Vanderkerken, Luc Bouwens, Nico Van Rooijen, Kit Van Den Berg, Marijke Baekeland, Eddie Wisse – 1 July 1995 – Pit cells, or hepatic natural killer (NK) cells, present in rat liver sinusoids, represent an organ‐associated NK cell population, with a higher level of activation and a different morphology when compared with peripheral blood NK cells. These cells are the result of an influx of peripheral blood NK cells in the liver microenvironment, followed by an activation or differentiation process toward the highly activated phenotype.