Hepatic biliary transport after hepatocyte transplantation in eizai hyperbilirubinemic rats

Hiromitsu Hamaguchi, Yasuo Yamaguchi, Mataro Goto, Mikio Misumi, Naoya Hisama, Nobutomo Miyanari, Katsutaka Mori, Michio Ogawa – 1 July 1994 – The Eizai hyperbilirubinemic rat (EHBR) is a Sprague‐Dawley mutant rat with conjugated hyperbilirubinemia. Eizai hyperbilirubinemic rats have impaired canalicular excretory transport of organic anions, bile acid glucuronide and sulfate. Eizai hyperbilirubinemic rats, with and without a 68% partial hepatectomy, were treated by an intraportal injection of 1×107 wild‐type Sprague‐Dawley mutant rat hepatocytes.

Vasopressin and phorbol‐12, 13‐dibutyrate inhibit glucagon‐ or cyclic AMP‐stimulated taurocholate uptake in isolated rat hepatocytes

Andras Divald, Edwin Simpser, Stanley E. Fisher, Peter I. Karl – 1 July 1994 – Bile salt uptake by hepatocytes is modulated in part by changes in intracellular cyclic AMP. We studied the effect of activation of protein kinase C on cyclic AMP‐mediated taurocholate uptake in isolated rat hepatocytes. Both dibutyryl cyclic AMP (2 × 10−6 mol/L) and glucagon (10−6 mol/L), which increase intracellular cyclic AMP, enhanced the initial uptake rate of taurocholate into hepatocytes, with maximal increases of 45% to 50% over the basal uptake rate.

Prostaglandin F2α and D2 release from primary ito cell cultures after stimulation with noradrenaline and ATP but not adenosine

Annette Athari, Kristina Hänecke, Kurt Jungermann – 1 July 1994 – Rat liver Ito cells were cultured for 24 hr with 20% newborn calf serum. Stimulation with the sympathetic neurotransmitter noradrenaline (0.1 μmol/L to 1 mmol/L) led to a dose‐dependent increase in prostaglandin F2α release and a slightly smaller enhancement of prostaglandin D2 production. Prostaglandin F2α and prostaglandin D2 release strongly. The relase was highest again during the first 30 sec. stimulation.

Primary biliary cirrhosis: Prediction of short‐term survival based on repeated patient visits

Paul A. Murtaugh, E. Rolland Dickson, Gooitzen M. Van Dam, Michael Malinchoc, Patricia M. Grambsch, Alice L. Langworthy, Chris H. Gips – 1 July 1994 – The progression of primary biliary cirrhosis was studied in 312 patients who were seen at the Mayo Clinic between January 1974 and May 1984. Follow‐up was extended to April 30, 1988, by which time 140 of the patients had died and 29 had undergone orthotopic liver transplantation.

Changes in the prevalence of HBeAg‐negative mutant hepatitis B virus during the course of chronic hepatitis B

Keisuke Hamasaki, Keisuke Nakata, Yuji Nagayama, Akira Ohtsuru, Manabu Daikoku, Kenji Taniguchi, Takuya Tsutsumi, Yoshiaki Sato, Yuji Kato, Shigenobu Nagataki – 1 July 1994 – Hepatitis B virus with a G‐to‐A point mutation at nucleotide 83 in the precore region (mutant hepatitis B virus 83), which cannot produce HBeAg, is commonly found in HBe antibody‐positive hepatitis B virus carriers. We analyzed the consecutive changes in the prevalence of mutant hepatitis B virus 83 during the course of chronic hepatitis B virus infection.

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