Paul A. Murtaugh, E. Rolland Dickson, Gooitzen M. Van Dam, Michael Malinchoc, Patricia M. Grambsch, Alice L. Langworthy, Chris H. Gips – 1 July 1994 – The progression of primary biliary cirrhosis was studied in 312 patients who were seen at the Mayo Clinic between January 1974 and May 1984. Follow‐up was extended to April 30, 1988, by which time 140 of the patients had died and 29 had undergone orthotopic liver transplantation.

Annette Athari, Kristina Hänecke, Kurt Jungermann – 1 July 1994 – Rat liver Ito cells were cultured for 24 hr with 20% newborn calf serum. Stimulation with the sympathetic neurotransmitter noradrenaline (0.1 μmol/L to 1 mmol/L) led to a dose‐dependent increase in prostaglandin F2α release and a slightly smaller enhancement of prostaglandin D2 production. Prostaglandin F2α and prostaglandin D2 release strongly. The relase was highest again during the first 30 sec. stimulation.

Andras Divald, Edwin Simpser, Stanley E. Fisher, Peter I. Karl – 1 July 1994 – Bile salt uptake by hepatocytes is modulated in part by changes in intracellular cyclic AMP. We studied the effect of activation of protein kinase C on cyclic AMP‐mediated taurocholate uptake in isolated rat hepatocytes. Both dibutyryl cyclic AMP (2 × 10−6 mol/L) and glucagon (10−6 mol/L), which increase intracellular cyclic AMP, enhanced the initial uptake rate of taurocholate into hepatocytes, with maximal increases of 45% to 50% over the basal uptake rate.

Hiromitsu Hamaguchi, Yasuo Yamaguchi, Mataro Goto, Mikio Misumi, Naoya Hisama, Nobutomo Miyanari, Katsutaka Mori, Michio Ogawa – 1 July 1994 – The Eizai hyperbilirubinemic rat (EHBR) is a Sprague‐Dawley mutant rat with conjugated hyperbilirubinemia. Eizai hyperbilirubinemic rats have impaired canalicular excretory transport of organic anions, bile acid glucuronide and sulfate. Eizai hyperbilirubinemic rats, with and without a 68% partial hepatectomy, were treated by an intraportal injection of 1×107 wild‐type Sprague‐Dawley mutant rat hepatocytes.

Paul D. Berk – 1 July 1994

Roy Calne – 1 July 1994

Garwin K. Sing, Raymond Pace, Sharon Prior, Janet S. D. Scott, Paul Shield, Nicole Martin, Jeffrey Searle, Cameron Battersby, Lawrie W. Powell, W. Graham E. Cooksley – 1 July 1994 – We describe the establishment and characterization of a novel hepatoma cell line. This cell line, designated RBHF‐1, was established from a hepatocellular carcinoma of a 67‐yr‐old man with a history of genetic hemochromatosis. At this writing, the cells have been maintained in RPMI‐1640 tissue‐culture medium and fetal calf serum without any additional supplements for 30 mo.

1 July 1994

Jean‐Pierre Benhamou – 1 July 1994

Marcel Blaise, Dominique Pateron, Jean‐Claude Trinchet, Serge Levacher, Michel Beaugrand, Jean‐Louis Pourriat – 1 July 1994 – This randomized prospective study was aimed at assessing the efficiency of a systemic antibiotic therapy for the prevention of bacterial infections in cirrhotic patients with gastrointestinal hemorrhage by ruptured esophageal varices. For 15 mo, all patients hospitalized with no infection on admission, were included in the study. Starting on admission day, patients in group A received ofloxacin (400 mg/day) for 10 days, first intravenously then orally.