Andras Divald, Edwin Simpser, Stanley E. Fisher, Peter I. Karl – 1 July 1994 – Bile salt uptake by hepatocytes is modulated in part by changes in intracellular cyclic AMP. We studied the effect of activation of protein kinase C on cyclic AMP‐mediated taurocholate uptake in isolated rat hepatocytes. Both dibutyryl cyclic AMP (2 × 10−6 mol/L) and glucagon (10−6 mol/L), which increase intracellular cyclic AMP, enhanced the initial uptake rate of taurocholate into hepatocytes, with maximal increases of 45% to 50% over the basal uptake rate.

Annette Athari, Kristina Hänecke, Kurt Jungermann – 1 July 1994 – Rat liver Ito cells were cultured for 24 hr with 20% newborn calf serum. Stimulation with the sympathetic neurotransmitter noradrenaline (0.1 μmol/L to 1 mmol/L) led to a dose‐dependent increase in prostaglandin F2α release and a slightly smaller enhancement of prostaglandin D2 production. Prostaglandin F2α and prostaglandin D2 release strongly. The relase was highest again during the first 30 sec. stimulation.

Paul A. Murtaugh, E. Rolland Dickson, Gooitzen M. Van Dam, Michael Malinchoc, Patricia M. Grambsch, Alice L. Langworthy, Chris H. Gips – 1 July 1994 – The progression of primary biliary cirrhosis was studied in 312 patients who were seen at the Mayo Clinic between January 1974 and May 1984. Follow‐up was extended to April 30, 1988, by which time 140 of the patients had died and 29 had undergone orthotopic liver transplantation.

Keisuke Hamasaki, Keisuke Nakata, Yuji Nagayama, Akira Ohtsuru, Manabu Daikoku, Kenji Taniguchi, Takuya Tsutsumi, Yoshiaki Sato, Yuji Kato, Shigenobu Nagataki – 1 July 1994 – Hepatitis B virus with a G‐to‐A point mutation at nucleotide 83 in the precore region (mutant hepatitis B virus 83), which cannot produce HBeAg, is commonly found in HBe antibody‐positive hepatitis B virus carriers. We analyzed the consecutive changes in the prevalence of mutant hepatitis B virus 83 during the course of chronic hepatitis B virus infection.

Henri Bismuth – 1 July 1994

Henri Bismuth – 1 July 1994

Eamonn M. M. Quigley, Guadalupe Garcia‐Tsao – 1 July 1994

Bijan Eghtesad, Oscar Bronsther, William Irish, Adrian Casavilla, Kareem Abu‐Elmagd, David Van Thiel, Andreas Tzakis, John J. Fung, Thomas E. Starzl – 1 July 1994 – One thousand one hundred and twenty‐eight candidates for liver transplantation were stratified into five urgency‐of‐need categories by the United Network for Organ Sharing (UNOS) criteria. Most patients of low‐risk UNOS 1 status remained alive after 1 yr without transplantation; the mortality while waiting was 3% after a median of 229.5 days.

Rudolf Pichlmayr, Arved Weimann, Burckhardt Ringe – 1 July 1994 – Our personal experience with 172 patients, the results from the European Liver Transplant Registry and a review of the recent literature are summarized and discussed to define present indications for liver transplantation in hepatobiliary malignancy. The following conditions should be considered contraindications: advanced primary liver tumors with any extrahepatic spread, cholangiocellular carcinoma, hemangiosarcoma and liver metastases from nonendocrine primary tumor.

Margaret J. Stalker, Trudy E. Kocal, Bette Anne Quinn, Sonya G. Gordon, M. Anthony Hayes – 1 July 1994 – We followed the expression of several glutathione S‐transferase subunits in altered foci, liver neoplasms and metastases produced in male Fischer 344 rats by a modified Solt‐Farber protocol, to determine whether components of the resistant phenotype are lost during neoplastic progression.