Vasopressin and phorbol‐12, 13‐dibutyrate inhibit glucagon‐ or cyclic AMP‐stimulated taurocholate uptake in isolated rat hepatocytes
Andras Divald, Edwin Simpser, Stanley E. Fisher, Peter I. Karl – 1 July 1994 – Bile salt uptake by hepatocytes is modulated in part by changes in intracellular cyclic AMP. We studied the effect of activation of protein kinase C on cyclic AMP‐mediated taurocholate uptake in isolated rat hepatocytes. Both dibutyryl cyclic AMP (2 × 10−6 mol/L) and glucagon (10−6 mol/L), which increase intracellular cyclic AMP, enhanced the initial uptake rate of taurocholate into hepatocytes, with maximal increases of 45% to 50% over the basal uptake rate.