Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice

Jesse D. Riordan, Charlotte R. Feddersen, Barbara R. Tschida, Pauline J. Beckmann, Vincent W. Keng, Michael A. Linden, Khalid Amin, Christopher S. Stipp, David A. Largaespada, Adam J. Dupuy – 29 September 2017 – Most hepatocellular carcinomas (HCCs) develop in a chronically injured liver, yet the extent to which this microenvironment promotes neoplastic transformation or influences selective pressures for genetic drivers of HCC remains unclear. We sought to determine the impact of hepatic injury in an established mouse model of HCC induced by Sleeping Beauty transposon mutagenesis.

Rate of seeding with biopsies and ablations of hepatocellular carcinoma: A retrospective cohort study

Jean‐Luc Szpakowski, Todd E. Drasin, Liisa L. Lyon – 29 September 2017 – Biopsies of liver masses that prove to be hepatocellular carcinomas (HCCs) are associated with a risk of seeding the abdominal or chest wall with tumor cells. The reported frequency of seeding varies greatly in the literature. We performed a retrospective cohort study in a large integrated health care system to examine rates of seeding in patients with HCC who had targeted liver biopsies, ablations, or both performed by community radiologists.

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Sandra Rebouissou, Paulette Bioulac‐Sage, Jean‐Charles Nault, Julien Calderaro, Jessica Zucman‐Rossi – 29 September 2017

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