Kyoko Yoshikawa, Motoh Iwasa, Akiko Eguchi, Shinichi Kojima, Naohiko Yoshizawa, Mina Tempaku, Ryosuke Sugimoto, Norihiko Yamamoto, Kazushi Sugimoto, Yoshinao Kobayashi, Hiroshi Hasegawa, Yoshiyuki Takei – 16 October 2017 – Chronic liver disease patients often have complications, such as hepatocellular carcinoma (HCC) and acute bacterial infection. Model for end‐stage liver disease and Child‐Pugh scores are useful prognostic factors for chronic liver diseases but not for all chronic conditions, such as HCC.

Linda Omer, Elizabeth A. Hudson, Shirong Zheng, James B. Hoying, Yuan Shan, Nolan L. Boyd – 16 October 2017 – Familial hypercholesterolemia (FH) is a hereditary disease primarily due to mutations in the low‐density lipoprotein receptor (LDLR) that lead to elevated cholesterol and premature development of cardiovascular disease. Homozygous FH patients (HoFH) with two dysfunctional LDLR alleles are not as successfully treated with standard hypercholesterol therapies, and more aggressive therapeutic approaches to control cholesterol levels must be considered.

Michael S. Middleton, Mark L. Van Natta, Elhamy R. Heba, Adina Alazraki, Andrew T. Trout, Prakash Masand, Elizabeth M. Brunt, David E. Kleiner, Edward Doo, James Tonascia, Joel E. Lavine, Wei Shen, Gavin Hamilton, Jeffrey B. Schwimmer, Claude B.

Yukihiro Sanada, Tomonori Yano, Taizen Urahashi, Yoshiyuki Ihara, Noriki Okada, Naoya Yamada, Yuta Hirata, Takumi Katano, Hironori Yamamoto, Koichi Mizuta – 12 October 2017

Christian von Loeffelholz, Andreas L. Birkenfeld – 12 October 2017

Adam C. Winters, Douglas Tremblay, Suzanne Arinsburg, John Mascarenhas, Thomas D. Schiano – 12 October 2017 – After publication of our manuscript, it came to our attention that the Australian Red Cross does indeed accept blood donations from patient with hemochromatosis (HH).

Ling Lu, Shi Yue, Longfeng Jiang, Changyong Li, Qiang Zhu, Michael Ke, Hao Lu, Xuehao Wang, Ronald W. Busuttil, Qi‐Long Ying, Jerzy W. Kupiec‐Weglinski, Bibo Ke – 12 October 2017 – Notch signaling plays an emerging role in the regulation of immune cell development and function during inflammatory response. Activation of the ras homolog gene family member A/Rho‐associated protein kinase (ROCK) pathway promotes leukocyte accumulation in tissue injury.

Beau Toskich, Tushar Patel – 12 October 2017

Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi – 12 October 2017 – Hepatocyte‐like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells are expected to be applied for regenerative medicine. In this study, we attempted to generate safe and therapeutically effective human iPS‐HLCs for hepatocyte transplantation.

Ju Dong Yang, Ajitha Mannalithara, Andrew J. Piscitello, John B. Kisiel, Gregory J. Gores, Lewis R. Roberts, W. Ray Kim – 12 October 2017 – Surveillance for hepatocellular carcinoma (HCC) has been recommended in patients with cirrhosis. In this study, we examined the extent to which the competing risk of hepatic decompensation influences the benefit of HCC surveillance by investigating the impact of availability of liver transplantation (LTx) and the rate of progression of hepatic decompensation on survival gain from HCC surveillance.