Erratum: Reassessing the Safety Concerns of Utilizing Blood Donations from Patients with Hemochromatosis

Adam C. Winters, Douglas Tremblay, Suzanne Arinsburg, John Mascarenhas, Thomas D. Schiano – 12 October 2017 – After publication of our manuscript, it came to our attention that the Australian Red Cross does indeed accept blood donations from patient with hemochromatosis (HH).

Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers

Ling Lu, Shi Yue, Longfeng Jiang, Changyong Li, Qiang Zhu, Michael Ke, Hao Lu, Xuehao Wang, Ronald W. Busuttil, Qi‐Long Ying, Jerzy W. Kupiec‐Weglinski, Bibo Ke – 12 October 2017 – Notch signaling plays an emerging role in the regulation of immune cell development and function during inflammatory response. Activation of the ras homolog gene family member A/Rho‐associated protein kinase (ROCK) pathway promotes leukocyte accumulation in tissue injury.

Generation of safe and therapeutically effective human induced pluripotent stem cell‐derived hepatocyte‐like cells for regenerative medicine

Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi – 12 October 2017 – Hepatocyte‐like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells are expected to be applied for regenerative medicine. In this study, we attempted to generate safe and therapeutically effective human iPS‐HLCs for hepatocyte transplantation.

Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis

Ju Dong Yang, Ajitha Mannalithara, Andrew J. Piscitello, John B. Kisiel, Gregory J. Gores, Lewis R. Roberts, W. Ray Kim – 12 October 2017 – Surveillance for hepatocellular carcinoma (HCC) has been recommended in patients with cirrhosis. In this study, we examined the extent to which the competing risk of hepatic decompensation influences the benefit of HCC surveillance by investigating the impact of availability of liver transplantation (LTx) and the rate of progression of hepatic decompensation on survival gain from HCC surveillance.

Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis

Ju Dong Yang, Ajitha Mannalithara, Andrew J. Piscitello, John B. Kisiel, Gregory J. Gores, Lewis R. Roberts, W. Ray Kim – 12 October 2017 – Surveillance for hepatocellular carcinoma (HCC) has been recommended in patients with cirrhosis. In this study, we examined the extent to which the competing risk of hepatic decompensation influences the benefit of HCC surveillance by investigating the impact of availability of liver transplantation (LTx) and the rate of progression of hepatic decompensation on survival gain from HCC surveillance.

Exercise and physical activity for patients with end‐stage liver disease: Improving functional status and sarcopenia while on the transplant waiting list

Andrés Duarte‐Rojo, Astrid Ruiz‐Margáin, Aldo J. Montaño‐Loza, Ricardo U. Macías‐Rodríguez, Arny Ferrando, W. Ray Kim – 11 October 2017 – Sarcopenia and physical deconditioning are frequent complications in patients with cirrhosis and end‐stage liver disease (ESLD). They are the end result of impaired dietary intake, chronic inflammation, altered macronutrient and micronutrient metabolism, and low physical activity. Frailty is the end result of prolonged sarcopenia and physical deconditioning.

Reply

Sarah Shalaby, Alberto Zanetto, Alessandro Vitale, Martina Gambato, Umberto Cillo, Fabio Farinati, Patrizia Burra, Francesco Paolo Russo – 11 October 2017

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