Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice

Jesse D. Riordan, Charlotte R. Feddersen, Barbara R. Tschida, Pauline J. Beckmann, Vincent W. Keng, Michael A. Linden, Khalid Amin, Christopher S. Stipp, David A. Largaespada, Adam J. Dupuy – 29 September 2017 – Most hepatocellular carcinomas (HCCs) develop in a chronically injured liver, yet the extent to which this microenvironment promotes neoplastic transformation or influences selective pressures for genetic drivers of HCC remains unclear. We sought to determine the impact of hepatic injury in an established mouse model of HCC induced by Sleeping Beauty transposon mutagenesis.

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