Hepatitis B virus sensitivity to interferon‐α in hepatocytes is more associated with cellular interferon response than with viral genotype

Fang Shen, Yaming Li, Yang Wang, Vitina Sozzi, Peter A. Revill, Jiangxia Liu, Lu Gao, Guang Yang, Mengji Lu, Kathrin Sutter, Ulf Dittmer, Jieliang Chen, Zhenghong Yuan – 23 October 2017 – Interferon‐α (IFN‐α) is used to treat chronic hepatitis B virus (HBV) infection, but only 20%‐40% of patients respond well. Clinical observations have suggested that HBV genotype is associated with the response to IFN therapy; however, its role in viral responsiveness to IFN in HBV‐infected hepatocytes remains unclear.

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia

Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T. Nies, Ulrich M. Zanger, Matthias Schwab – 23 October 2017 – Neurotoxic bilirubin is the end product of heme catabolism in mammals. Bilirubin is solely conjugated by uridine diphospho‐glucuronosyltransferase 1A1, which is a membrane‐bound enzyme that catalyzes the transfer of glucuronic acid. Due to low function of hepatic and intestinal uridine diphospho‐glucuronosyltransferase 1A1 during the neonatal period, human neonates develop mild to severe physiological hyperbilirubinemia.

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

Thomas Leibing, Cyrill Géraud, Iris Augustin, Michael Boutros, Hellmut G. Augustin, Jürgen G. Okun, Claus‐Dieter Langhans, Johanna Zierow, Sebastian A. Wohlfeil, Victor Olsavszky, Kai Schledzewski, Sergij Goerdt, Philipp‐Sebastian Koch – 23 October 2017 – Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes has been identified as an important regulator of final adult liver size and metabolic liver zonation.

Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science

Mohammad Shadab Siddiqui, Stephen A. Harrison, Manal F. Abdelmalek, Quentin M. Anstee, Pierre Bedossa, Laurent Castera, Lara Dimick‐Santos, Scott L. Friedman, Katherine Greene, David E. Kleiner, Sophie Megnien, Brent A. Neuschwander‐Tetri, Vlad Ratziu, Elmer Schabel, Veronica Miller, Arun J. Sanyal, on behalf of the Liver Forum Case Definitions Working Group – 23 October 2017 – Nonalcoholic steatohepatitis (NASH) is an important cause of liver‐related morbidity and mortality.

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia

Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T. Nies, Ulrich M. Zanger, Matthias Schwab – 23 October 2017 – Neurotoxic bilirubin is the end product of heme catabolism in mammals. Bilirubin is solely conjugated by uridine diphospho‐glucuronosyltransferase 1A1, which is a membrane‐bound enzyme that catalyzes the transfer of glucuronic acid. Due to low function of hepatic and intestinal uridine diphospho‐glucuronosyltransferase 1A1 during the neonatal period, human neonates develop mild to severe physiological hyperbilirubinemia.

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