A risk score to predict the development of hepatic encephalopathy in a population‐based cohort of patients with cirrhosis

Elliot B. Tapper, Neehar D. Parikh, Neil Sengupta, Jessica Mellinger, David Ratz, Anna S.‐F. Lok, Grace L. Su – 1 November 2017 – Over 40% of patients with cirrhosis will develop hepatic encephalopathy (HE). HE is associated with decreased survival, falls, motor vehicle accidents, and frequent hospitalization. Accordingly, we aimed to develop a tool to risk‐stratify patients for HE development.

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform

Kirk J. Wangensteen, Yue J. Wang, Zhixun Dou, Amber W. Wang, Elham Mosleh‐Shirazi, Max A. Horlbeck, Luke A. Gilbert, Jonathan S. Weissman, Shelley L. Berger, Klaus H. Kaestner – 1 November 2017 – Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated 9 activation (CRISPRa) systems have enabled genetic screens in cultured cell lines to discover and characterize drivers and inhibitors of cancer cell growth.

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