The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

Puneet Puri, Suthat Liangpunsakul, Jeffrey E. Christensen, Vijay H. Shah, Patrick S. Kamath, Gregory J. Gores, Susan Walker, Megan Comerford, Barry Katz, Andrew Borst, Qigui Yu, Divya P. Kumar, Faridoddin Mirshahi, Svetlana Radaeva, Naga P. Chalasani, David W. Crabb, Arun J. Sanyal, for the TREAT Consortium – 30 October 2017 – Intestinal dysbiosis is implicated in alcoholic hepatitis (AH). However, changes in the circulating microbiome, its association with the presence and severity of AH, and its functional relevance in AH is unknown.

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis

Jun Xu, Hsiao‐Yen Ma, Shuang Liang, Mengxi Sun, Gabriel Karin, Yukinori Koyama, Ronglin Hu, Oswald Quehenberger, Nicholas O. Davidson, Edward A. Dennis, Tatiana Kisseleva, David A. Brenner – 30 October 2017 – Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species. Reactive oxygen species‐induced oxidative stress promotes hepatocyte injury and death, which in turn induces inflammation, activation of hepatic stellate cells, and liver fibrosis.

Subscribe to