Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver

Siyuan Wang, Zhen‐Zhen Yan, Xia Yang, Shimin An, Kuo Zhang, Yu Qi, Jilin Zheng, Yan‐Xiao Ji, Pi‐Xiao Wang, Chun Fang, Xue‐Yong Zhu, Li‐Jun Shen, Feng‐Juan Yan, Rong Bao, Song Tian, Zhi‐Gang She, Yi‐Da Tang – 27 October 2017 – Nonalcoholic fatty liver disease (NAFLD) is a prevalent and complex disease that confers a high risk of severe liver disorders. Despite such public and clinical health importance, very few effective therapies are currently available for NAFLD.

Pro (With Caution): Extended oncologic indications in liver transplantation

Vincenzo Mazzaferro, Carlo Battiston, Carlo Sposito – 27 October 2017 – The success of liver transplantation (LT) in curing cancer (particularly hepatocellular carcinoma and hepatic metastases from neuroendocrine tumors) is based on the augmented oncologic potentials of the total hepatectomy and on restrictive criteria applied to patient selection. Consensus on the grade of expansion of conventional limits and implementation of alternative indications to LT (cholangiocarcinoma and metastases from colorectal cancer) has not been reached.

Nutrition and the transplant candidate

Vera C. Mazurak, Puneeta Tandon, Aldo J. Montano‐Loza – 26 October 2017 – Cirrhosis is the most common indication for liver transplantation (LT) worldwide. Malnutrition is present in at least two‐thirds of patients with cirrhosis awaiting LT. It negatively impacts survival, quality of life, and the ability to respond to stressors, such as infection and surgery. Muscle wasting or sarcopenia is the most objective feature of chronic protein malnutrition in cirrhosis, and this condition is associated with increased morbidity and mortality before and after LT.

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