Jun Xu, Hsiao‐Yen Ma, Shuang Liang, Mengxi Sun, Gabriel Karin, Yukinori Koyama, Ronglin Hu, Oswald Quehenberger, Nicholas O. Davidson, Edward A. Dennis, Tatiana Kisseleva, David A. Brenner – 30 October 2017 – Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species. Reactive oxygen species‐induced oxidative stress promotes hepatocyte injury and death, which in turn induces inflammation, activation of hepatic stellate cells, and liver fibrosis.

Jesús Quintero Bernabeu, Juan Ortega López, Javier Juampérez Goñi, Ecaterina Julio Tatis, Maria Mercadal‐Hally, Itxarone Bilbao Aguirre, Carlos Rodrigo Gonzalo de Liria, Ramon Charco Torra – 28 October 2017

Jiaye Liu – 28 October 2017

Janakan Satkunasingham, Hooman Hosseini Nik, Sandra Fischer, Ravi Menezes, Nazia Selzner, Mark Cattral, David Grant, Kartik Jhaveri – 28 October 2017 – The purpose of this study is to determine whether magnetic resonance (MR)–proton density fat fraction (PDFF) estimate of negligible hepatic fat percentage (<5%) can exclude significant hepatic steatosis (≥10%) in living liver donor candidates obviating the need for liver biopsy and to perform intraindividual comparisons between MR‐PDFF techniques for hepatic steatosis quantification.

Guo‐Feng Chen, Cheng Wang, George Lau – 28 October 2017

Emanuele Nicastro, Lorenzo D'Antiga – 28 October 2017 – Next generation sequencing (NGS) has revolutionized the analysis of human genetic variations, offering a highly cost‐effective way to diagnose monogenic diseases (MDs). Because nearly half of the children with chronic liver disorders have a genetic cause and approximately 20% of pediatric liver transplantations are performed in children with MDs, NGS offers the opportunity to significantly improve the diagnostic yield in this field.

R. Todd Stravitz, Michelle Gottfried, Valerie Durkalski, Robert J. Fontana, A. James Hanje, David Koch, Bilal Hameed, Daniel Ganger, Ram M. Subramanian, Stan Bukofzer, William R. Ravis, Kristen Clasen, Averell Sherker, Lanna Little, William M. Lee, for the Acute Liver Failure Study Group – 28 October 2017 – Cerebral edema remains a significant cause of morbidity and mortality in patients with acute liver failure (ALF) and has been linked to elevated blood ammonia levels.

Atoosa Rabiee, James P.A. Hamilton – 27 October 2017

Shuichi Aoki, Mark Cobbold, Andrew X. Zhu, Dan G. Duda – 27 October 2017

Vincenzo Mazzaferro, Carlo Battiston, Carlo Sposito – 27 October 2017 – The success of liver transplantation (LT) in curing cancer (particularly hepatocellular carcinoma and hepatic metastases from neuroendocrine tumors) is based on the augmented oncologic potentials of the total hepatectomy and on restrictive criteria applied to patient selection. Consensus on the grade of expansion of conventional limits and implementation of alternative indications to LT (cholangiocarcinoma and metastases from colorectal cancer) has not been reached.