Cytidine‐5'‐Diphosphocholine Protects the Liver From Ischemia/Reperfusion Injury Preserving Mitochondrial Function and Reducing Oxidative Stress

Cecilia Zazueta, Mabel Buelna‐Chontal, Arturo Macías‐López, Nadia G. Román‐Anguiano, Héctor González‐Pacheco, Natalia Pavón, Rashidi Springall, Alberto Aranda‐Frausto, Rafael Bojalil, Alejandro Silva‐Palacios, Rodrigo Velázquez‐Espejel, Sonia Galvan Arzate, Francisco Correa – 20 April 2018 – Cytidine‐5'‐diphosphocholine (CDP‐choline) participates as an intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes.

Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Eloi R. Verrier, Seung‐Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon‐Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert – 20 April 2018 – Chronic hepatitis B virus (HBV) infection is a major cause of chronic liver disease and cancer worldwide. The mechanisms of viral genome sensing and the evasion of innate immune responses by HBV infection are still poorly understood.

Cytokine‐Producing B Cells Promote Immune‐Mediated Bile Duct Injury in Murine Biliary Atresia

Joseph Bednarek, Brianna Traxinger, Dania Brigham, Jonathan Roach, David Orlicky, Dong Wang, Roberta Pelanda, Cara L. Mack – 20 April 2018 – Biliary atresia (BA) is a neonatal T cell–mediated, inflammatory, sclerosing cholangiopathy. In the rhesus rotavirus (RRV)–induced neonatal mouse model of BA (murine BA), mice lacking B cells do not develop BA, and the lack of B cells is associated with loss of T‐cell and macrophage activation. The aim of this study was to determine the mechanism of B cell–mediated immune activation (antigen presentation versus cytokine production) in murine BA.

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