The role of human cytochrome P450 2E1 in liver inflammation and fibrosis

Jun Xu, Hsiao‐Yen Ma, Shuang Liang, Mengxi Sun, Gabriel Karin, Yukinori Koyama, Ronglin Hu, Oswald Quehenberger, Nicholas O. Davidson, Edward A. Dennis, Tatiana Kisseleva, David A. Brenner – 30 October 2017 – Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species. Reactive oxygen species‐induced oxidative stress promotes hepatocyte injury and death, which in turn induces inflammation, activation of hepatic stellate cells, and liver fibrosis.

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