Ruochan Chen, Shan Zhu, Xue‐Gong Fan, Haichao Wang, Michael T. Lotze, Herbert J. Zeh, Timothy R. Billiar, Rui Kang, Daolin Tang – 17 November 2017 – Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver tumor metabolic reprogramming remains elusive. Here, we provide evidence that high mobility group box 1 (HMGB1), a chromosomal protein, plays a role in the regulation of the Hippo pathway during liver tumorigenesis.

Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Toshihiro Kitajima, Soichi Narumoto, Yoshihiro Hirata, Tomoro Hishiki, Akinari Fukuda, Mureo Kasahara – 16 November 2017

Abhishek Chauhan, David H. Adams – 16 November 2017

Joachim Andrassy, Sebastian Wolf, Michael Lauseker, Martin Angele, Marieke D. van Rosmalen, Undine Samuel, Xavier Rogiers, Jens Werner, Markus Guba, for the Eurotransplant Liver Advisory Committee – 16 November 2017 – Split‐liver transplantation has been perceived as an important strategy to increase the supply of liver grafts by creating 2 transplants from 1 allograft. The Eurotransplant Liver Allocation System (ELAS) envisages that the extended right lobes (ERLs) after splitting (usually in the pediatric center) are almost exclusively shipped to a second center.

Akanksha Sharma, Chandrashekhar R. Gandhi – 16 November 2017

Josep M. Llovet, Mihai Pavel, Jordi Rimola, Maria Alba Diaz, Jordi Colmenero, David Saavedra-Perez, Constantino Fondevila, Carmen Ayuso, Josep Fuster, Pere Ginès, Jordi Bruix, Juan Carlos Garcia-Valdecasas – 15 November 2017 – A subset of patients with hepatocellular carcinoma (HCC) beyond Milan criteria might obtain acceptable survival outcomes after liver transplantation. Living donor liver transplantation (LDLT) has emerged as a feasible alternative to overcome the paucity of donors.

Daniel A. Jaramillo‐Calle, Omar Castaño Quintero, Juan‐Ignacio Marín, Alicia M. Cock‐Rada, Oscar Santos Sánchez, Octavio Muñoz, Juan‐Carlos Restrepo – 15 November 2017

Patrick Starlinger, David Pereyra, Stefanie Haegele, Paul Braeuer, Lukas Oehlberger, Florian Primavesi, Andreas Kohler, Florian Offensperger, Thomas Reiberger, Arnulf Ferlitsch, Barbara Messner, Guido Beldi, Stefan Staettner, Christine Brostjan, Thomas Gruenberger – 15 November 2017 – von Willebrand Factor (vWF) was found to mediate platelet influx during the early phase of liver regeneration in mice. Furthermore, increased vWF‐antigen (vWF‐Ag) levels were shown to be predictive for outcome of patients with chronic liver disease.

Chune Liu, Zhihong Yang, Jianguo Wu, Li Zhang, Sangmin Lee, Dong‐Ju Shin, Melanie Tran, Li Wang – 15 November 2017 – H19 is an imprinted long noncoding RNA abundantly expressed in embryonic liver and repressed after birth. We show that H19 serves as a lipid sensor by synergizing with the RNA‐binding polypyrimidine tract‐binding protein 1 (PTBP1) to modulate hepatic metabolic homeostasis. H19 RNA interacts with PTBP1 to facilitate its association with sterol regulatory element‐binding protein 1c mRNA and protein, leading to increased stability and nuclear transcriptional activity.

Marta B. Afonso, Cecília M.P. Rodrigues – 15 November 2017