Molecular profiling of postreperfusion milieu determines acute kidney injury after liver transplantation: A prospective study

Carlo Pulitano, Phong Ho, Deborah Verran, Charbel Sandroussi, David Joseph, David G. Bowen, Geoffrey W. McCaughan, Michael Crawford, Nicholas Shackel – 23 April 2018 – Acute kidney injury (AKI) after liver transplantation (LT) is a common event, but its pathogenesis remains unclear. The aim of this prospective study is to investigate the potential relationship between postreperfusion gene expression, serum mediators, and the onset of AKI after LT. Sixty‐five consecutive patients undergoing LT were included in the study.

Cytidine‐5'‐Diphosphocholine Protects the Liver From Ischemia/Reperfusion Injury Preserving Mitochondrial Function and Reducing Oxidative Stress

Cecilia Zazueta, Mabel Buelna‐Chontal, Arturo Macías‐López, Nadia G. Román‐Anguiano, Héctor González‐Pacheco, Natalia Pavón, Rashidi Springall, Alberto Aranda‐Frausto, Rafael Bojalil, Alejandro Silva‐Palacios, Rodrigo Velázquez‐Espejel, Sonia Galvan Arzate, Francisco Correa – 20 April 2018 – Cytidine‐5'‐diphosphocholine (CDP‐choline) participates as an intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes.

Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Eloi R. Verrier, Seung‐Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon‐Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert – 20 April 2018 – Chronic hepatitis B virus (HBV) infection is a major cause of chronic liver disease and cancer worldwide. The mechanisms of viral genome sensing and the evasion of innate immune responses by HBV infection are still poorly understood.

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