Francesca Faggioli, Eleonora Palagano, Luca Di Tommaso, Matteo Donadon, Veronica Marrella, Camilla Recordati, Stefano Mantero, Anna Villa, Paolo Vezzoni, Barbara Cassani – 3 November 2017 – Hepatocellular carcinoma (HCC) is a frequent neoplasia and a leading cause of inflammation‐related cancer mortality. Despite that most HCCs arise from persistent inflammatory conditions, pathways linking chronic inflammation to cancer development are still incompletely elucidated.

Hilda E. Ghadieh, Harrison T. Muturi, Lucia Russo, Christopher C. Marino, Simona S. Ghanem, Saja S. Khuder, Julie C. Hanna, Sukanta Jash, Vishwajeet Puri, Garrett Heinrich, Cara Gatto‐Weis, Kevin Y. Lee, Sonia M. Najjar – 2 November 2017 – Exenatide, a glucagon‐like peptide‐1 receptor agonist, induces insulin secretion. Its role in insulin clearance has not been adequately examined. Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance to maintain insulin sensitivity.

Jorge Matias Caviglia, Jun Yan, Myoung‐Kuk Jang, Geum‐Youn Gwak, Silvia Affo, Lexing Yu, Peter Olinga, Richard A. Friedman, Xin Chen, Robert F. Schwabe – 1 November 2017 – Fibrosis and cancer represent two major complications of chronic liver disease. MicroRNAs have been implicated in the development of fibrosis and cancer, thus constituting potential therapeutic targets.

Jillian L. Ellis, Kevin E. Bove, Erin G. Schuetz, Daniel Leino, C. Alexander Valencia, John D. Schuetz, Alexander Miethke, Chunyue Yin – 1 November 2017 – Bile salt export pump (BSEP) adenosine triphosphate–binding cassette B11 (ABCB11) is a liver‐specific ABC transporter that mediates canalicular bile salt excretion from hepatocytes. Human mutations in ABCB11 cause progressive familial intrahepatic cholestasis type 2.

Yao Lu, Zhou Jiang, Haijiang Dai, Rujia Miao, Jingxian Shu, Haotian Gu, Xing Liu, Zhijun Huang, Guoping Yang, Alex F. Chen, Hong Yuan, Ying Li, Jingjing Cai – 1 November 2017 – Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent liver pathology characterized by hepatic steatosis and commonly accompanied by systematic inflammation and metabolic disorder. Despite an accumulating number of studies, no pharmacological strategy is available to treat this condition in the clinic.

Marco Carbone, Giulia Bonato, Pietro Invernizzi – 1 November 2017

Jorge Matias Caviglia, Jun Yan, Myoung‐Kuk Jang, Geum‐Youn Gwak, Silvia Affo, Lexing Yu, Peter Olinga, Richard A. Friedman, Xin Chen, Robert F. Schwabe – 1 November 2017 – Fibrosis and cancer represent two major complications of chronic liver disease. MicroRNAs have been implicated in the development of fibrosis and cancer, thus constituting potential therapeutic targets.

Reben Raeman, Frank A. Anania – 1 November 2017

Elliot B. Tapper, Neehar D. Parikh, Neil Sengupta, Jessica Mellinger, David Ratz, Anna S.‐F. Lok, Grace L. Su – 1 November 2017 – Over 40% of patients with cirrhosis will develop hepatic encephalopathy (HE). HE is associated with decreased survival, falls, motor vehicle accidents, and frequent hospitalization. Accordingly, we aimed to develop a tool to risk‐stratify patients for HE development.

Kirk J. Wangensteen, Yue J. Wang, Zhixun Dou, Amber W. Wang, Elham Mosleh‐Shirazi, Max A. Horlbeck, Luke A. Gilbert, Jonathan S. Weissman, Shelley L. Berger, Klaus H. Kaestner – 1 November 2017 – Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated 9 activation (CRISPRa) systems have enabled genetic screens in cultured cell lines to discover and characterize drivers and inhibitors of cancer cell growth.