Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C

Ezequiel Mauro, Gonzalo Crespo, Carla Montironi, Maria‐Carlota Londoño, Virginia Hernández‐Gea, Pablo Ruiz, Lydia Sastre, Julissa Lombardo, Zoe Mariño, Alba Díaz, Jordi Colmenero, Antoni Rimola, Juan Carlos Garcia‐Pagán, Mercé Brunet, Xavier Forns, Miquel Navasa – 27 September 2017 – Sustained virological response (SVR) improves survival in post‐liver transplant (LT) recurrent hepatitis C. However, the impact of SVR on fibrosis regression is not well defined.

The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis

Zhen‐Wei Peng, Sonja Rothweiler, Guangyan Wei, Naoki Ikenaga, Susan B. Liu, Deanna Y. Sverdlov, Kahini A. Vaid, Maria Serena Longhi, Ming Kuang, Simon C. Robson, Yury V. Popov – 26 September 2017 – The pathogenesis of primary sclerosing cholangitis (PSC) and the mechanistic link to inflammatory bowel disease remain ill‐defined. Ectonucleoside triphosphate diphosphohydrolase‐1 (ENTPD1)/clusters of differentiation (CD) 39, the dominant purinergic ecto‐enzyme, modulates intestinal inflammation. Here, we have explored the role of CD39 in biliary injury and fibrosis.

Progression of liver fibrosis is associated with non‐liver‐related mortality in patients with nonalcoholic fatty liver disease

Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Kazuyuki Mizuno, Yasuhiro Sone, Tomoyuki Akita, Junko Tanaka – 26 September 2017 – In patients with nonalcoholic fatty liver disease (NAFLD), prognosis and outcome, especially non‐liver‐related mortality, remain incompletely elucidated. We clarified the mortality from all causes in patients with NAFLD. A total of 4,073 patients with NAFLD diagnosed by ultrasonography were enrolled.

Segregated hepatocyte proliferation and metabolic states within the regenerating mouse liver

Shilpi Minocha, Dominic Villeneuve, Leonor Rib, Catherine Moret, Nicolas Guex, Winship Herr – 26 September 2017 – Mammalian partial hepatectomy (PH) induces an orchestrated compensatory hyperplasia, or regeneration, in remaining tissue to restore liver mass; during this process, liver functions are maintained. We probed this process in mice with feeding‐ and light/dark‐entrained animals subjected to sham or PH surgery.

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