25 October 2018

25 October 2018

Shi Liu, Bin Zhou, Juan D. Valdes, Jian Sun, Haitao Guo – 25 October 2018 – Chronic hepatitis B infection is one of the major etiological causes of liver failure, cirrhosis, and hepatocellular carcinoma (HCC) worldwide. This condition cannot be completely cured by currently available drugs due to the persistent existence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), the bona fide transcription template for HBV RNAs, in infected hepatocytes.

Hynek Mergental, Barnaby T. F. Stephenson, Richard W. Laing, Amanda J. Kirkham, Desley A. H. Neil, Lorraine L. Wallace, Yuri L. Boteon, Jeannette Widmer, Ricky H. Bhogal, M. Thamara P. R. Perera, Amanda Smith, Gary M. Reynolds, Christina Yap, Stefan G. Hübscher, Darius F. Mirza, Simon C. Afford – 25 October 2018 – Increased use of high‐risk allografts is critical to meet the demand for liver transplantation. We aimed to identify criteria predicting viability of organs, currently declined for clinical transplantation, using functional assessment during normothermic machine perfusion (NMP).

Shi Liu, Bin Zhou, Juan D. Valdes, Jian Sun, Haitao Guo – 25 October 2018 – Chronic hepatitis B infection is one of the major etiological causes of liver failure, cirrhosis, and hepatocellular carcinoma (HCC) worldwide. This condition cannot be completely cured by currently available drugs due to the persistent existence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), the bona fide transcription template for HBV RNAs, in infected hepatocytes.

This webinar focuses on reviewing the highlights of the revised AASLD Clinical Practice Guidelines for HBV infection in the first talk.  The second presentation addresses a key area of controversy, namely the role of antiviral therapy in patients during the immunotolerant phase of chronic HBV infection.Naga P. Chalasani (Moderator) Naga P. Chalasani, MD, FAASLD currently serves as David W. Crabb Professor of Medicine and Interim Chair of the Department of Medicine at Indiana University School of Medicine.

Teh‐Ia Huo, Po‐Hong Liu, Chia‐Yang Hsu – 24 October 2018

Hiroyuki Kato, Sergio Duarte, Mary G. Miller, Ronald W. Busuttil, Ana J. Coito – 24 October 2018 – The purpose of this study was to assess the significance of tenascin‐C (Tnc) expression in steatotic liver ischemia/reperfusion injury (IRI). The critical shortage in donor organs has led to the use of steatotic livers in transplantation regardless of their elevated susceptibility to hepatic IRI. Tnc is an endogenous danger signal extracellular matrix molecule involved in various aspects of immunity and tissue injury.

Martin Gaillard, Hadrien Tranchart, Panagiotis Lainas, Olivier Trassard, Séverine Remy, Anne Dubart‐Kupperschmitt, Ibrahim Dagher – 24 October 2018 – Hepatocyte transplantation (HT) has emerged as a promising alternative to orthotopic liver transplantation, yet liver preconditioning is needed to promote hepatocyte engraftment. A method of temporary occlusion of the portal flow called reversible portal vein embolization (RPVE) has been demonstrated to be an efficient method of liver preconditioning.

Ying Fu, Daniel J. Urban, Roger R. Nani, Yi‐Fan Zhang, Nan Li, Haiying Fu, Hamzah Shah, Alexander P. Gorka, Rajarshi Guha, Lu Chen, Matthew D. Hall, Martin J. Schnermann, Mitchell Ho – 24 October 2018 – Hepatocellular carcinoma (HCC) is the second most common cause of cancer‐related death in the world. Therapeutic outcomes of HCC remain unsatisfactory, and novel treatments are urgently needed.