Ying Fu, Daniel J. Urban, Roger R. Nani, Yi‐Fan Zhang, Nan Li, Haiying Fu, Hamzah Shah, Alexander P. Gorka, Rajarshi Guha, Lu Chen, Matthew D. Hall, Martin J. Schnermann, Mitchell Ho – 24 October 2018 – Hepatocellular carcinoma (HCC) is the second most common cause of cancer‐related death in the world. Therapeutic outcomes of HCC remain unsatisfactory, and novel treatments are urgently needed.
Teh‐Ia Huo, Po‐Hong Liu, Chia‐Yang Hsu – 24 October 2018
Sandeep Satsangi – 24 October 2018
Martin Gaillard, Hadrien Tranchart, Panagiotis Lainas, Olivier Trassard, Séverine Remy, Anne Dubart‐Kupperschmitt, Ibrahim Dagher – 24 October 2018 – Hepatocyte transplantation (HT) has emerged as a promising alternative to orthotopic liver transplantation, yet liver preconditioning is needed to promote hepatocyte engraftment. A method of temporary occlusion of the portal flow called reversible portal vein embolization (RPVE) has been demonstrated to be an efficient method of liver preconditioning.
Hiroyuki Kato, Sergio Duarte, Mary G. Miller, Ronald W. Busuttil, Ana J. Coito – 24 October 2018 – The purpose of this study was to assess the significance of tenascin‐C (Tnc) expression in steatotic liver ischemia/reperfusion injury (IRI). The critical shortage in donor organs has led to the use of steatotic livers in transplantation regardless of their elevated susceptibility to hepatic IRI. Tnc is an endogenous danger signal extracellular matrix molecule involved in various aspects of immunity and tissue injury.
Jakob Damsgaard, Fin Stolze Larsen, Henriette Ytting – 23 October 2018
Marion J.D. Robin, Monique D. Appelman, Harmjan R. Vos, Robert M. van Es, James C. Paton, Adrienne W. Paton, Boudewijn Burgering, Peter Fickert, Jarom Heijmans, Stan F.J. van de Graaf – 23 October 2018 – Cholestasis‐induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)‐mediated transcriptional down‐regulation of the bile acid importer Na+‐taurocholate cotransporting protein (NTCP) and to induction of endoplasmic reticulum (ER) stress. However, whether ER stress affects bile acid uptake is largely unknown.
Jakob Damsgaard, Fin Stolze Larsen, Henriette Ytting – 23 October 2018
Oriol Juanola, Paula Piñero, Isabel Gómez‐Hurtado, Esther Caparrós, Rocío García‐Villalba, Alicia Marín, Pedro Zapater, Fabián Tarín, José M. González‐Navajas, Francisco A. Tomás‐Barberán, Rubén Francés – 22 October 2018 – Intestinal permeability to translocation of bacterial products is increased in cirrhosis. Regulatory T cells (Tregs) remain central to the interplay between the host and microbial milieu. We propose that Tregs are involved in promoting gut barrier integrity and a balanced interaction with gut microbiota–derived short‐chain fatty acids (SCFAs).
Mauro Bernardi, Giacomo Zaccherini, Paolo Caraceni – 22 October 2018 – The wait‐list mortality of patients with decompensated cirrhosis awaiting liver transplantation remains elevated due to the occurrence of complications. Etiologic treatments improve patient survival and lower the incidence of complications when applied in compensated cirrhosis, but a decompensated disease does not improve or even progress despite a response to therapy in a substantial number of patients. Thus, disease‐modifying treatments that reduce the incidence of complications and improve survival are most needed.