Notices
5 October 2018
Hepatic Stellate Cells and Retinoids: Toward A Much More Defined Relationship
William S. Blaner – 4 October 2018
DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1
Hao Zhang, Yanqiu Zhang, Xiaoyun Zhu, Chen Chen, Chao Zhang, Yuanzheng Xia, Yucheng Zhao, Ourania Andrisani, Lingyi Kong – 3 October 2018 – In hepatocellular carcinoma (HCC), dysregulated expression of DDX5 (DEAD box protein 5) and impaired autophagy have been reported separately. However, the relationship between them has not been explored. Here we present evidence to show that, by interacting with autophagic receptor p62, DDX5 promotes autophagy and suppresses tumorigenesis.
Is Terlipressin Superior to Noradrenaline in the Treatment of Acute Kidney Injury in Acute‐on‐Chronic Liver Failure?
Abhinav Anand, Shalimar – 3 October 2018
LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA‐378 Transcription and Inhibition of Ppargc1β Expression
Tianpeng Zhang, Jiangyan Duan, Lei Zhang, Zhuoyu Li, Clifford J. Steer, Guiqin Yan, Guisheng Song – 3 October 2018 – Nonalcoholic fatty liver disease (NAFLD) is a major risk factor of many end‐stage liver diseases. Alterations in microRNA expression have been reported in patients with NAFLD. However, the transcriptional mechanism(s) of dysregulated microRNAs under the state of NAFLD is poorly described, and microRNAs that regulate the pathogenesis of NAFLD synergistically with their regulators remain unknown.
Deceased Pediatric Donor Livers: How Current Policy Drives Allocation and Transplantation
Jin Ge, Evelyn K. Hsu, John Bucuvalas, Jennifer C. Lai – 3 October 2018 – Each year, approximately 60 children, representing 12% of waitlist candidates, die awaiting liver transplantation. The current allocation algorithm for pediatric donor livers prioritizes local/regional adults over national children. We attempted to better understand the impact of the present algorithm on pediatric candidates. We analyzed pediatric donor liver offers from 2010 to 2014. Donors and recipients were classified based on age.
Primer on Percutaneous Ablation of Benign Liver Tumors
Shane A. Wells, Timothy J. Ziemlewicz, Meghan G. Lubner – 2 October 2018
CON: Anticoagulation for Portal Vein Thrombosis in Advanced Cirrhosis
Kevin M. Rank, John Lake – 2 October 2018
Down‐regulation of TROP‐2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients
Sarah T. K. Sin, Yan Li, Ming Liu, Yun‐Fei Yuan, Stephanie Ma, Xin‐Yuan Guan – 2 October 2018 – Hepatocellular carcinoma (HCC) is one of the most common and lethal cancer types worldwide, especially in Asian countries. Genetic alterations, including hyperactivation of oncogenes and loss of expression of tumor suppressor genes, greatly contribute to the initiation and progression of HCC. Here we report that down‐regulation of trophoblast cell surface antigen 2 (TROP‐2) was frequently detected in HCC.