Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Jesus M. Banales, Mercedes Iñarrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi Muntané, Luis Muñoz‐Bellvis, Adelaida La Casta, Luis M. Gonzalez, Enara Arretxe, Cristina Alonso, Ibon Martínez‐Arranz, Ainhoa Lapitz, Alvaro Santos‐Laso, Matias A. Avila, Maria L. Martínez‐Chantar, Luis Bujanda, Jose J.G. Marin, Bruno Sangro, Rocio I.R. Macias – 16 October 2018 – Early and differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) by noninvasive methods represents a current clinical challenge.

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Young‐Sun Lee, Myung Han Hyun, Sun Young Yim, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun – 16 October 2018

Colder Weather and Fewer Sunlight Hours Increase Alcohol Consumption and Alcoholic Cirrhosis Worldwide

Meritxell Ventura‐Cots, Ariel E. Watts, Monica Cruz‐Lemini, Neil D. Shah, Nambi Ndugga, Peter McCann, A. S. Barritt, Anant Jain, Samhita Ravi, Carlos Fernandez‐Carrillo, Juan G. Abraldes, Jose Altamirano, Ramon Bataller – 16 October 2018 – Risk of alcoholic cirrhosis is determined by genetic and environmental factors. We aimed to investigate if climate has a causal effect on alcohol consumption and its weight on alcoholic cirrhosis. We collected extensive data from 193 sovereign countries as well as 50 states and 3,144 counties in the United States.

Identification and Replication of Six Loci Associated With Gallstone Disease

Helene Gellert‐Kristensen, Nawar Dalila, Sune Fallgaard Nielsen, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Stefan Stender – 16 October 2018 – Gallstone disease is a common complex disease that confers a substantial economic burden on society. The genetic underpinnings of gallstone disease remain incompletely understood. We aimed to identify genetic associations with gallstone disease using publicly available data from the UK Biobank and two large Danish cohorts.

Identification and Replication of Six Loci Associated With Gallstone Disease

Helene Gellert‐Kristensen, Nawar Dalila, Sune Fallgaard Nielsen, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Stefan Stender – 16 October 2018 – Gallstone disease is a common complex disease that confers a substantial economic burden on society. The genetic underpinnings of gallstone disease remain incompletely understood. We aimed to identify genetic associations with gallstone disease using publicly available data from the UK Biobank and two large Danish cohorts.

Colder Weather and Fewer Sunlight Hours Increase Alcohol Consumption and Alcoholic Cirrhosis Worldwide

Meritxell Ventura‐Cots, Ariel E. Watts, Monica Cruz‐Lemini, Neil D. Shah, Nambi Ndugga, Peter McCann, A. S. Barritt, Anant Jain, Samhita Ravi, Carlos Fernandez‐Carrillo, Juan G. Abraldes, Jose Altamirano, Ramon Bataller – 16 October 2018 – Risk of alcoholic cirrhosis is determined by genetic and environmental factors. We aimed to investigate if climate has a causal effect on alcohol consumption and its weight on alcoholic cirrhosis. We collected extensive data from 193 sovereign countries as well as 50 states and 3,144 counties in the United States.

Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Jesus M. Banales, Mercedes Iñarrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi Muntané, Luis Muñoz‐Bellvis, Adelaida La Casta, Luis M. Gonzalez, Enara Arretxe, Cristina Alonso, Ibon Martínez‐Arranz, Ainhoa Lapitz, Alvaro Santos‐Laso, Matias A. Avila, Maria L. Martínez‐Chantar, Luis Bujanda, Jose J.G. Marin, Bruno Sangro, Rocio I.R. Macias – 16 October 2018 – Early and differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) by noninvasive methods represents a current clinical challenge.

Combination of Entecavir/Peginterferon Alfa‐2a in Children With Hepatitis B e Antigen–Positive Immune Tolerant Chronic Hepatitis B Virus Infection

Philip Rosenthal, Simon C. Ling, Steven H. Belle, Karen F. Murray, Norberto Rodriguez‐Baez, Sarah J. Schwarzenberg, Jeffrey Teckman, Hsing‐Hua S. Lin, Kathleen B. Schwarz, for the Hepatitis B Research Network (HBRN) – 15 October 2018 – The optimal management strategy for children with immune‐tolerant chronic hepatitis B virus (HBV) infection remains unknown. The purpose of this clinical trial was to determine the safety and efficacy of therapy with entecavir and peginterferon in a group of children in the immune‐tolerant phase of HBV infection.

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