Liraglutide, Sitagliptin, and Insulin Glargine Added to Metformin: The Effect on Body Weight and Intrahepatic Lipid in Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease

Jinhua Yan, Bin Yao, Hongyu Kuang, Xubin Yang, Qin Huang, Tianpei Hong, Yushu Li, Jingtao Dou, Wenying Yang, Guijun Qin, Huijuan Yuan, Xinhua Xiao, Sihui Luo, Zhongyan Shan, Hongrong Deng, Ying Tan, Fen Xu, Wen Xu, Longyi Zeng, Zhuang Kang, Jianping Weng – 19 October 2018 – To investigate the effect of antidiabetic agents on nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM), 75 patients with T2DM and NAFLD under inadequate glycemic control by metformin were randomized (1:1:1) to receive add‐on liraglutide, sitagliptin, or insulin glargine in this 26‐w

A Model for Glomerular Filtration Rate Assessment in Liver Disease (GRAIL) in the Presence of Renal Dysfunction

Sumeet K. Asrani, Linda W. Jennings, James F. Trotter, Josh Levitsky, Mitra K. Nadim, W.R. Kim, Stevan A. Gonzalez, Bernard Fischbach, Ranjeeta Bahirwani, Michael Emmett, Goran Klintmalm – 19 October 2018 – Estimation of glomerular filtration rate (eGFR) in patients with liver disease is suboptimal in the presence of renal dysfunction. We developed a model for GFR assessment in liver disease (GRAIL) before and after liver transplantation (LT).

Endoscopic Management of Benign Biliary Strictures After Liver Transplantation

Alberto Larghi, Andrea Tringali, Mihai Rimbaş, Federico Barbaro, Vincenzo Perri, Gianenrico Rizzatti, Antonio Gasbarrini, Guido Costamagna – 17 October 2018 – Biliary strictures represent some of the most frequent complications encountered after orthotopic liver transplantation. They comprise an array of biliary abnormalities with variations in anatomical location, clinical presentation, and different pathogenesis.

Natural Killer Cell–Derived Interferon‐Gamma Promotes Hepatocellular Carcinoma Through the Epithelial Cell Adhesion Molecule–Epithelial‐to‐Mesenchymal Transition Axis in Hepatitis B Virus Transgenic Mice

Yongyan Chen, Xiaolei Hao, Rui Sun, Haiming Wei, Zhigang Tian – 17 October 2018 – Hepatitis B virus (HBV) is a major risk factor for development of hepatocellular carcinoma (HCC), at least partially due to dysfunctional anti‐HBV adaptive immunity; however, the role of innate immune response to HBV in this process is not well understood.

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Young‐Sun Lee, Myung Han Hyun, Sun Young Yim, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun – 16 October 2018

Colder Weather and Fewer Sunlight Hours Increase Alcohol Consumption and Alcoholic Cirrhosis Worldwide

Meritxell Ventura‐Cots, Ariel E. Watts, Monica Cruz‐Lemini, Neil D. Shah, Nambi Ndugga, Peter McCann, A. S. Barritt, Anant Jain, Samhita Ravi, Carlos Fernandez‐Carrillo, Juan G. Abraldes, Jose Altamirano, Ramon Bataller – 16 October 2018 – Risk of alcoholic cirrhosis is determined by genetic and environmental factors. We aimed to investigate if climate has a causal effect on alcohol consumption and its weight on alcoholic cirrhosis. We collected extensive data from 193 sovereign countries as well as 50 states and 3,144 counties in the United States.

Colder Weather and Fewer Sunlight Hours Increase Alcohol Consumption and Alcoholic Cirrhosis Worldwide

Meritxell Ventura‐Cots, Ariel E. Watts, Monica Cruz‐Lemini, Neil D. Shah, Nambi Ndugga, Peter McCann, A. S. Barritt, Anant Jain, Samhita Ravi, Carlos Fernandez‐Carrillo, Juan G. Abraldes, Jose Altamirano, Ramon Bataller – 16 October 2018 – Risk of alcoholic cirrhosis is determined by genetic and environmental factors. We aimed to investigate if climate has a causal effect on alcohol consumption and its weight on alcoholic cirrhosis. We collected extensive data from 193 sovereign countries as well as 50 states and 3,144 counties in the United States.

Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Jesus M. Banales, Mercedes Iñarrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi Muntané, Luis Muñoz‐Bellvis, Adelaida La Casta, Luis M. Gonzalez, Enara Arretxe, Cristina Alonso, Ibon Martínez‐Arranz, Ainhoa Lapitz, Alvaro Santos‐Laso, Matias A. Avila, Maria L. Martínez‐Chantar, Luis Bujanda, Jose J.G. Marin, Bruno Sangro, Rocio I.R. Macias – 16 October 2018 – Early and differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) by noninvasive methods represents a current clinical challenge.

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