Readdressing the Middle Hepatic Vein in Right Lobe Liver Donation: Triangle of Safety

Sanjay Goja, Sanjay Kumar Yadav, Arvinder Singh Soin – 25 October 2018 – For equipoising donor safety and optimal recipient outcomes, we adopted an algorithmic “triangle of safety” approach to retrieve 3 types of right lobe liver grafts (RLGs), namely, the modified extended right lobe graft (MERLG), the partial right lobe graft (PRLG), and the modified right lobe graft (MRLG). Reconstruction to achieve a single wide anterior sector outflow was ensured in all patients.

LiverLearning®: 2018 Webinar: HBV - Update on the Guidelines and Controversies in Management

This webinar focuses on reviewing the highlights of the revised AASLD Clinical Practice Guidelines for HBV infection in the first talk.  The second presentation addresses a key area of controversy, namely the role of antiviral therapy in patients during the immunotolerant phase of chronic HBV infection.Naga P. Chalasani (Moderator) Naga P. Chalasani, MD, FAASLD currently serves as David W. Crabb Professor of Medicine and Interim Chair of the Department of Medicine at Indiana University School of Medicine.

Glypican‐3‐Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma

Ying Fu, Daniel J. Urban, Roger R. Nani, Yi‐Fan Zhang, Nan Li, Haiying Fu, Hamzah Shah, Alexander P. Gorka, Rajarshi Guha, Lu Chen, Matthew D. Hall, Martin J. Schnermann, Mitchell Ho – 24 October 2018 – Hepatocellular carcinoma (HCC) is the second most common cause of cancer‐related death in the world. Therapeutic outcomes of HCC remain unsatisfactory, and novel treatments are urgently needed.

Improving Hepatocyte Engraftment Following Hepatocyte Transplantation Using Repeated Reversible Portal Vein Embolization in Rats

Martin Gaillard, Hadrien Tranchart, Panagiotis Lainas, Olivier Trassard, Séverine Remy, Anne Dubart‐Kupperschmitt, Ibrahim Dagher – 24 October 2018 – Hepatocyte transplantation (HT) has emerged as a promising alternative to orthotopic liver transplantation, yet liver preconditioning is needed to promote hepatocyte engraftment. A method of temporary occlusion of the portal flow called reversible portal vein embolization (RPVE) has been demonstrated to be an efficient method of liver preconditioning.

Overproduction of Tenascin‐C Driven by Lipid Accumulation in the Liver Aggravates Hepatic Ischemia/Reperfusion Injury in Steatotic Mice

Hiroyuki Kato, Sergio Duarte, Mary G. Miller, Ronald W. Busuttil, Ana J. Coito – 24 October 2018 – The purpose of this study was to assess the significance of tenascin‐C (Tnc) expression in steatotic liver ischemia/reperfusion injury (IRI). The critical shortage in donor organs has led to the use of steatotic livers in transplantation regardless of their elevated susceptibility to hepatic IRI. Tnc is an endogenous danger signal extracellular matrix molecule involved in various aspects of immunity and tissue injury.

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