Pilot, Open, Randomized, Prospective Trial for Normothermic Machine Perfusion Evaluation in Liver Transplantation From Older Donors

Davide Ghinolfi, Erion Rreka, Vincenzo De Tata, Maria Franzini, Daniele Pezzati, Vanna Fierabracci, Matilde Masini, Andrea Cacciatoinsilla, Maria Lucia Bindi, Lorella Marselli, Valentina Mazzotti, Riccardo Morganti, Piero Marchetti, Giandomenico Biancofiore, Daniela Campani, Aldo Paolicchi, Paolo De Simone – 26 October 2018 – Ex situ normothermic machine perfusion (NMP) might minimize ischemia/reperfusion injury (IRI) of liver grafts. In this study, 20 primary liver transplantation recipients of older grafts (≥70 years) were randomized 1:1 to NMP or cold storage (CS) groups.

Magnetic Resonance Imaging Is Cost‐Effective for Hepatocellular Carcinoma Surveillance in High‐Risk Patients With Cirrhosis

Hye‐Lin Kim, Jihyun An, Jae‐A Park, Seung‐Hoo Park, Young‐Suk Lim, Eui‐Kyung Lee – 26 October 2018 – Ultrasonography (US) is generally recommended for the surveillance of hepatocellular carcinoma (HCC) in patients at risk. However, in patients with cirrhosis who have sufficiently high HCC incidence, surveillance using magnetic resonance imaging (MRI) with liver‐specific contrast showed markedly higher sensitivity in detecting early‐stage HCC than US.

Readdressing the Middle Hepatic Vein in Right Lobe Liver Donation: Triangle of Safety

Sanjay Goja, Sanjay Kumar Yadav, Arvinder Singh Soin – 25 October 2018 – For equipoising donor safety and optimal recipient outcomes, we adopted an algorithmic “triangle of safety” approach to retrieve 3 types of right lobe liver grafts (RLGs), namely, the modified extended right lobe graft (MERLG), the partial right lobe graft (PRLG), and the modified right lobe graft (MRLG). Reconstruction to achieve a single wide anterior sector outflow was ensured in all patients.

Differences in Posttransplant Hepatocellular Carcinoma Recurrence by Etiology of Liver Disease

Nadim Mahmud, Abraham Shaked, Kim M. Olthoff, David S. Goldberg – 25 October 2018 – The 5‐year incidence of posttransplant hepatocellular carcinoma (HCC) recurrence is 8%‐20%. Several studies have evaluated pretransplant risk factors for HCC recurrence, but nearly all data have treated HCC as a homogeneous condition across all etiologies of liver disease despite differences in tumor biology and baseline incidence of HCC.

Primary Stent Placement for Hepatic Artery Stenosis After Liver Transplantation: Improving Primary Patency and Reintervention Rates

Ammar Sarwar, Christine Chen, Khalid Khwaja, Raza Malik, Kristin E. Raven, Jeffrey L. Weinstein, Amy Evenson, Salomao Faintuch, Robert Fisher, Michael P. Curry, Muneeb Ahmed – 25 October 2018 – Recent studies have reported high rates of reintervention after primary stenting for hepatic artery stenosis (HAS) due to the loss of primary patency. The aims of this study were to evaluate the outcomes of primary stenting after HAS in a large cohort with longterm follow‐up.

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