LiverLearning®: Hepatitis C SIG: Navigating the road to elimination of HCV in the U.S.

This program covers the key components that support efforts to define a program toward eradication of HCV in the U.S.  The program is centered around modeling, engagement of individuals difficult to link to care and screening efforts.  Access to care and the role of advocacy is instrumental and approaches toward successful advocacy will also be discussed.John W. Ward John W. Ward, MD created and directs the Coalition for Global Hepatitis Elimination of the Task Force for Global Health.

LiverLearning®: Hepatotoxicity SIG: Herbal and Dietary Supplement Induced Liver Injury: Defining the Future

This program will focus on liver injury due to herbal and dietary supplements. The program will begin with a description of a realworld case of liver injury due to OxyElite Pro, which highlights the challenges faced by diagnosticians and researchers in establishing causation for hepatotoxicity due to herbal and dietary supplements. The program will also review the role of the FDA, CDC and chemists, including scientists with the National Center for Natural Products Research, at the University of Mississippi, who perform product chemical analyses.Victor J. Navarro Victor J.

LiverLearning®: Clinical Research Workshop: Researching and Applying Precision Medicine in Hepatology

Precision medicine has the potential to completely revolutionize health care research and treatment – allowing doctors and researchers to more accurately predict which treatment and prevention strategies for a particular disease will work in individual patients or groups of patients vs. a one-size-fits all paradigm.

The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis

Eva Santamaría, Carlos M. Rodríguez‐Ortigosa, Iker Uriarte, Maria U. Latasa, Raquel Urtasun, Gloria Alvarez‐Sola, Marina Bárcena‐Varela, Leticia Colyn, Sara Arcelus, Maddalen Jiménez, Kathleen Deutschmann, Ana Peleteiro‐Vigil, Julian Gómez‐Cambronero, Malgorzata Milkiewicz, Piotr Milkiewicz, Bruno Sangro, Verena Keitel, Maria J. Monte, Jose J.G. Marin, Maite G. Fernández‐Barrena, Matias A. Ávila, Carmen Berasain – 8 November 2018 – Intrahepatic accumulation of bile acids (BAs) causes hepatocellular injury.

Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma

Haoyu Sun, Qiang Huang, Mei Huang, Hao Wen, Renyong Lin, Meijuan Zheng, Kun Qu, Kun Li, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian, Cheng Sun – 8 November 2018 – Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between three receptors fine‐tunes immune responses against tumors.

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