The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis

Eva Santamaría, Carlos M. Rodríguez‐Ortigosa, Iker Uriarte, Maria U. Latasa, Raquel Urtasun, Gloria Alvarez‐Sola, Marina Bárcena‐Varela, Leticia Colyn, Sara Arcelus, Maddalen Jiménez, Kathleen Deutschmann, Ana Peleteiro‐Vigil, Julian Gómez‐Cambronero, Malgorzata Milkiewicz, Piotr Milkiewicz, Bruno Sangro, Verena Keitel, Maria J. Monte, Jose J.G. Marin, Maite G. Fernández‐Barrena, Matias A. Ávila, Carmen Berasain – 8 November 2018 – Intrahepatic accumulation of bile acids (BAs) causes hepatocellular injury.

Estimating Prevalence of Hepatitis C Virus Infection in the United States, 2013‐2016

Megan G. Hofmeister, Elizabeth M. Rosenthal, Laurie K. Barker, Eli S. Rosenberg, Meredith A. Barranco, Eric W. Hall, Brian R. Edlin, Jonathan Mermin, John W. Ward, A. Blythe Ryerson – 6 November 2018 – Hepatitis C virus (HCV) infection is the most commonly reported bloodborne infection in the United States, causing substantial morbidity and mortality and costing billions of dollars annually.

A Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma

Divya P. Kumar, Prasanna K. Santhekadur, Mulugeta Seneshaw, Faridoddin Mirshahi, Cora Uram‐Tuculescu, Arun J. Sanyal – 5 November 2018 – Hepatocellular carcinoma (HCC) is increasing as a cause of liver‐related mortality largely because of the growing burden of nonalcoholic steatohepatitis (NASH). The mechanisms of HCC development in nonalcoholic fatty liver disease (NAFLD) are incompletely understood. We initially identified apoptosis antagonizing transcription factor (AATF) to be associated with HCC in a mouse model of NASH that develops HCC without the addition of specific carcinogens.

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