Ashwin Rammohan, Mettu S. Reddy, Gomathy Narasimhan, Rajesh Rajalingam, Ilankumaran Kaliamoorthy, Naresh Shanmugam, Mohamed Rela – 13 October 2018 – Auxiliary partial orthotopic liver transplantation (APOLT) in selected noncirrhotic metabolic liver diseases (NCMLDs) is a viable alternative to orthotopic liver transplantation (OLT) as it supplements the function of the native liver with the missing functional protein. APOLT for NCMLD is not universally accepted due to concerns of increased technical complications and longterm graft atrophy.

Jacob D. de Boer, Joris J. Blok, Hein Putter, Jacob J. E. Koopman, Bart van Hoek, Undine Samuel, Marieke van Rosmalen, Herold J. Metselaar, Ian P. J. Alwayn, Markus Guba, Andries E. Braat, for the Eurotransplant Liver and Intestine Advisory Committee – 13 October 2018 – Acceptance criteria for liver allografts are ever more expanding because of a persisting wait‐list mortality. Older livers are therefore offered and used more frequently for transplantation. This study aims to analyze the use and longterm outcome of these transplantations.

Marco Sanduzzi‐Zamparelli, Álvaro Díaz‐Gonzalez, María Reig – 13 October 2018 – The principal advancements in the treatment of hepatocellular carcinoma (HCC) are the use of new systemic treatments, such as lenvatinib in first‐line treatment and regorafenib, cabozantinib, and ramucirumab in second‐line treatment, because of their benefits in terms of overall survival. In addition, nivolumab as a second‐line agent was approved by the US Food and Drug Administration in 2017 based on improved radiological response data.

Lorenzo Anez‐Bustillos, Duy T. Dao, Alexis K. Potemkin, Antonio R. Perez‐Atayde, Bram P. Raphael, Alexandra N. Carey, Daniel S. Kamin, Jay R. Thiagarajah, McGreggor Crowley, Kathleen M. Gura, Mark Puder – 12 October 2018

Lorenzo Anez‐Bustillos, Duy T. Dao, Alexis K. Potemkin, Antonio R. Perez‐Atayde, Bram P. Raphael, Alexandra N. Carey, Daniel S. Kamin, Jay R. Thiagarajah, McGreggor Crowley, Kathleen M. Gura, Mark Puder – 12 October 2018

Dominique Debray, Haquima El Mourabit, Fatiha Merabtene, Loïc Brot, Damien Ulveling, Yves Chrétien, Dominique Rainteau, Ivan Moszer, Dominique Wendum, Harry Sokol, Chantal Housset – 10 October 2018 – The most typical expression of cystic fibrosis (CF)–related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the potential impact of environmental and genetic factors on the development of CF‐related cholangiopathy in mice.

Peter Fickert – 10 October 2018

Axelle Cooreman, Raf Van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati, Mathieu Vinken – 9 October 2018 – Connexin proteins are the building blocks of hemichannels, which dock further between adjacent cells to form gap junctions. Gap junctions control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions control virtually all aspects of the hepatic life cycle.

Adrian P. Mansini, Estanislao Peixoto, Sujeong Jin, Seth Richard, Sergio A. Gradilone – 9 October 2018 – Cholangiocytes, the epithelial cells lining the biliary tree in the liver, express primary cilia that can detect several kinds of environmental signals and then transmit this information into the cell. We have reported that cilia are significantly reduced in cholangiocarcinoma (CCA) and that the experimental deciliation of normal cells induces a malignant‐like phenotype with increased proliferation, anchorage‐independent growth, invasion, and migration.

Axelle Cooreman, Raf Van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati, Mathieu Vinken – 9 October 2018 – Connexin proteins are the building blocks of hemichannels, which dock further between adjacent cells to form gap junctions. Gap junctions control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions control virtually all aspects of the hepatic life cycle.