Dominique Debray, Haquima El Mourabit, Fatiha Merabtene, Loïc Brot, Damien Ulveling, Yves Chrétien, Dominique Rainteau, Ivan Moszer, Dominique Wendum, Harry Sokol, Chantal Housset – 10 October 2018 – The most typical expression of cystic fibrosis (CF)–related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the potential impact of environmental and genetic factors on the development of CF‐related cholangiopathy in mice.

Peter Fickert – 10 October 2018

Axelle Cooreman, Raf Van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati, Mathieu Vinken – 9 October 2018 – Connexin proteins are the building blocks of hemichannels, which dock further between adjacent cells to form gap junctions. Gap junctions control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions control virtually all aspects of the hepatic life cycle.

Adrian P. Mansini, Estanislao Peixoto, Sujeong Jin, Seth Richard, Sergio A. Gradilone – 9 October 2018 – Cholangiocytes, the epithelial cells lining the biliary tree in the liver, express primary cilia that can detect several kinds of environmental signals and then transmit this information into the cell. We have reported that cilia are significantly reduced in cholangiocarcinoma (CCA) and that the experimental deciliation of normal cells induces a malignant‐like phenotype with increased proliferation, anchorage‐independent growth, invasion, and migration.

Axelle Cooreman, Raf Van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati, Mathieu Vinken – 9 October 2018 – Connexin proteins are the building blocks of hemichannels, which dock further between adjacent cells to form gap junctions. Gap junctions control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions control virtually all aspects of the hepatic life cycle.

Eunkyong Ko, Hyun‐Wook Seo, Eun Sun Jung, Soomi Ju, Baek‐hui Kim, Hyeki Cho, Yoon Jun Kim, Young Min Park, Jong‐Seo Kim, Guhung Jung – 9 October 2018 – Class I phosphoinositide 3‐kinase (PI3K) signaling is a major pathway in human cancer development and progression. Among the four PI3K isoforms, PI3Kα and PI3Kβ are ubiquitously expressed, whereas PI3Kγ and PI3Kδ are found primarily in leukocytes. Until now, PI3K targeting in solid tumors has focused on inhibiting PI3Kα‐mediated and PI3Kβ‐mediated cancer cell–intrinsic PI3K activity. The role of PI3Kδ in solid tumors is unknown.

Maria J. Perugorria, Paula Olaizola, Jesus M. Banales – 8 October 2018

Nila J. Dharan, Jacqueline Neuhaus, Juergen K. Rockstroh, Lars Peters, Fred Gordin, Alejandro Arenas‐Pinto, Carol Emerson, Kristen Marks, Jose Hidalgo, Rui Sarmento‐Castro, Christoph Stephan, Nagalingeswaran Kumarasamy, Sean Emery, Gail V. Matthews, for the INSIGHT START Study Group – 8 October 2018 – The role of antiretroviral therapy (ART) in reducing or contributing to liver fibrosis in persons with human immunodeficiency virus (HIV) is unclear.

Giorgio A. Roccaro, Robert Mitrani, Wei‐Ting Hwang, Kimberly A. Forde, K. Rajender Reddy – 6 October 2018 – Posttransplant diabetes mellitus (PTDM), an increasingly recognized complication of solid organ transplantation, is associated with increased morbidity and mortality following liver transplantation (LT). Hepatitis C virus (HCV) infection is a consistent and modifiable risk factor for PTDM. Prior studies have demonstrated improvement in glucose metabolism following sustained virological response (SVR).

Shih‐Wei Lai – 5 October 2018