Evaluating Noninvasive Markers to Identify Advanced Fibrosis by Liver Biopsy in HBV/HIV Co‐infected Adults

Richard K. Sterling, Wendy C. King, Abdus S. Wahed, David E. Kleiner, Mandana Khalili, Mark Sulkowski, Raymond T. Chung, Mamta K. Jain, Mauricio Lisker‐Melman, David K. Wong, Marc G. Ghany, the HIV‐HBV Cohort Study of the Hepatitis B Research Network – 20 June 2019 – Noninvasive biomarkers are used increasingly to assess fibrosis in patients with chronic liver disease.

Ledipasvir‐Sofosbuvir for 12 Weeks in Children 3 to <6 Years Old With Chronic Hepatitis C

Kathleen B. Schwarz, Philip Rosenthal, Karen F. Murray, Jonathan R. Honegger, Winita Hardikar, Rosie Hague, Naveen Mittal, Benedetta Massetto, Diana M. Brainard, Chia‐Hsiang Hsueh, Jiang Shao, Bandita Parhy, Michael R. Narkewicz, Girish S. Rao, Suzanne Whitworth, Sanjay Bansal, William F. Balistreri – 20 June 2019 – For children under 12 years of age who have chronic hepatitis C virus (HCV) infection, there are currently no approved treatments with direct‐acting antiviral agents.

Neuroinflammation in Murine Cirrhosis Is Dependent on the Gut Microbiome and Is Attenuated by Fecal Transplant

Runping Liu, Jason D. Kang, R. Balfour Sartor, Masoumeh Sikaroodi, Andrew Fagan, Edith A. Gavis, Huiping Zhou, Phillip B. Hylemon, Jeremy W. Herzog, Xiaojiaoyang Li, Robert H. Lippman, Javier Gonzalez‐Maeso, James B. Wade, Siddhartha Ghosh, Emily Gurley, Patrick M. Gillevet, Jasmohan S. Bajaj – 20 June 2019 – Cirrhosis and hepatic encephalopathy (HE) is associated with an altered gut–liver–brain axis. Fecal microbial transplant (FMT) after antibiotics improves outcomes in HE, but the impact on brain function is unclear.

Exome Sequencing in Clinical Hepatology

Sílvia Vilarinho, Pramod K. Mistry – 20 June 2019 – The clinical relevance of the Human Genome Project and next‐generation sequencing technology was demonstrated for the first time in 2009, when whole‐exome sequencing (WES) provided the definitive diagnosis of congenital chloride diarrhea in an infant with presumed renal salt‐wasting disease. Over the past decade, numerous studies have shown the utility of WES for clinical diagnosis as well as for discovery of novel genetic disorders through analysis of a single or a handful of informative pedigrees.

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