Connie W. Wang, Adrienne Lebsack, Stephanie Chau, Jennifer C. Lai – 18 March 2019 – The Liver Frailty Index (LFI), composed of 3 performance‐based tests (grip strength, chair stands, and balance), is a tool specifically developed in patients with cirrhosis to objectively measure physical function, a critical determinant of health outcomes.
Damiano Patrono, Eloisa Franchi, Fabio Guarasci, Germana Bartoli, Elisabetta Nada, Federica Rigo, Antonio Ottobrelli, Paolo Fonio, Mauro Salizzoni, Renato Romagnoli – 18 March 2019 – Splenic artery (SA) ligation can be performed during liver transplantation (LT) to avoid portal hyperperfusion, which is involved in the pathogenesis of both small‐for‐size and SA syndrome. The SA can also be used as an inflow for arterial reconstruction.
Brian P. Lee, Gene Y. Im, John P. Rice, Ethan Weinberg, Christine Hsu, Oren K. Fix, George Therapondos, Hyosun Han, David W. Victor, Sheila Eswaran, Haripriya Maddur, Norah A. Terrault – 18 March 2019 – Alcohol‐associated liver disease (ALD) can be coded in United Network for Organ Sharing (UNOS) as either alcoholic cirrhosis or alcoholic hepatitis (AH), without having specific criteria to assign either diagnosis.
Kelly L. Hayward, Preya J. Patel, Patricia C. Valery, Leigh U. Horsfall, Catherine Y. Li, Penny L. Wright, Caroline J. Tallis, Katherine A. Stuart, Katharine M. Irvine, W. Neil Cottrell, Jennifer H. Martin, Elizabeth E. Powell – 18 March 2019 – People with decompensated cirrhosis are often prescribed a complex regimen of therapeutic and prophylactic medications. In other chronic diseases, polypharmacy increases the risk of medication misadventure and medication‐related problems (MRPs), with associated increased morbidity, mortality, and health care costs.
Lovkesh Anand, Ashok Choudhury, S.K. Sarin – 15 March 2019
Pengfei Liu, Montserrat Rojo Vega, Matthew Dodson, Fei Yue, Boyun Shi, Deyu Fang, Eli Chapman, Leyuan Liu, Donna D. Zhang – 15 March 2019 – Spermidine (SPD), a naturally occurring polyamine, has been recognized as a caloric restriction mimetic that confers health benefits, presumably by inducing autophagy. Recent studies have reported that oral administration of SPD protects against liver fibrosis and hepatocarcinogenesis through activation of microtubule associated protein 1S (MAP1S)–mediated autophagy.
Raymond J. Lynch, Fei Ye, Quanhu Sheng, Zhiguo Zhao, Seth J. Karp – 14 March 2019 – Allocation of livers for transplantation faces regulatory pressure to move toward broader sharing. A current proposal supported by the United Network for Organ Sharing Board of Directors relies on concentric circles, but its effect on socioeconomic inequities in access to transplant services is poorly understood.
Yun‐Long Wang, Jin‐Yu Liu, Jin‐E Yang, Xiao‐Man Yu, Zhan‐Li Chen, Ya‐Jing Chen, Ming Kuang, Ying Zhu, Shi‐Mei Zhuang – 13 March 2019 – Although thousands of long noncoding RNAs (lncRNAs) have been annotated, only a limited number of them have been functionally characterized. Here, we identified an oncogenic lncRNA, named lnc‐UCID (lncRNA up‐regulating CDK6 by interacting with DHX9). Lnc‐UCID was up‐regulated in hepatocellular carcinoma (HCC), and a higher lnc‐UCID level was correlated with shorter recurrence‐free survival of HCC patients.
Noriki Okada, Yukihiro Sanada, Yasuharu Onishi, Taizen Urahashi, Yoshiyuki Ihara, Naoya Yamada, Yuta Hirata, Takumi Katano, Toshimi Imai, Kentaro Ushijima, Keiko Ogaki, Shinya Otomo, Koichi Mizuta – 13 March 2019 – Early relaparotomy of adult recipients after living donor liver transplantation (LDLT) is significantly associated with poor prognosis. However, there are few reports focusing on pediatric recipients after LDLT. The aim of this study is to clarify the causes and outcomes of early relaparotomy after pediatric LDLT.