Natural Killer Cell–Derived Interferon‐Gamma Promotes Hepatocellular Carcinoma Through the Epithelial Cell Adhesion Molecule–Epithelial‐to‐Mesenchymal Transition Axis in Hepatitis B Virus Transgenic Mice

Yongyan Chen, Xiaolei Hao, Rui Sun, Haiming Wei, Zhigang Tian – 17 October 2018 – Hepatitis B virus (HBV) is a major risk factor for development of hepatocellular carcinoma (HCC), at least partially due to dysfunctional anti‐HBV adaptive immunity; however, the role of innate immune response to HBV in this process is not well understood.

Endoscopic Management of Benign Biliary Strictures After Liver Transplantation

Alberto Larghi, Andrea Tringali, Mihai Rimbaş, Federico Barbaro, Vincenzo Perri, Gianenrico Rizzatti, Antonio Gasbarrini, Guido Costamagna – 17 October 2018 – Biliary strictures represent some of the most frequent complications encountered after orthotopic liver transplantation. They comprise an array of biliary abnormalities with variations in anatomical location, clinical presentation, and different pathogenesis.

Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Jesus M. Banales, Mercedes Iñarrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi Muntané, Luis Muñoz‐Bellvis, Adelaida La Casta, Luis M. Gonzalez, Enara Arretxe, Cristina Alonso, Ibon Martínez‐Arranz, Ainhoa Lapitz, Alvaro Santos‐Laso, Matias A. Avila, Maria L. Martínez‐Chantar, Luis Bujanda, Jose J.G. Marin, Bruno Sangro, Rocio I.R. Macias – 16 October 2018 – Early and differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) by noninvasive methods represents a current clinical challenge.

Identification and Replication of Six Loci Associated With Gallstone Disease

Helene Gellert‐Kristensen, Nawar Dalila, Sune Fallgaard Nielsen, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Stefan Stender – 16 October 2018 – Gallstone disease is a common complex disease that confers a substantial economic burden on society. The genetic underpinnings of gallstone disease remain incompletely understood. We aimed to identify genetic associations with gallstone disease using publicly available data from the UK Biobank and two large Danish cohorts.

Identification and Replication of Six Loci Associated With Gallstone Disease

Helene Gellert‐Kristensen, Nawar Dalila, Sune Fallgaard Nielsen, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Stefan Stender – 16 October 2018 – Gallstone disease is a common complex disease that confers a substantial economic burden on society. The genetic underpinnings of gallstone disease remain incompletely understood. We aimed to identify genetic associations with gallstone disease using publicly available data from the UK Biobank and two large Danish cohorts.

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Young‐Sun Lee, Myung Han Hyun, Sun Young Yim, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun – 16 October 2018

Colder Weather and Fewer Sunlight Hours Increase Alcohol Consumption and Alcoholic Cirrhosis Worldwide

Meritxell Ventura‐Cots, Ariel E. Watts, Monica Cruz‐Lemini, Neil D. Shah, Nambi Ndugga, Peter McCann, A. S. Barritt, Anant Jain, Samhita Ravi, Carlos Fernandez‐Carrillo, Juan G. Abraldes, Jose Altamirano, Ramon Bataller – 16 October 2018 – Risk of alcoholic cirrhosis is determined by genetic and environmental factors. We aimed to investigate if climate has a causal effect on alcohol consumption and its weight on alcoholic cirrhosis. We collected extensive data from 193 sovereign countries as well as 50 states and 3,144 counties in the United States.

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