Subtypes of antimitochondrial antibodies in primary biliary cirrhosis before and after orthotopic liver transplantation

Elizabeth B. Haagsma, Michael Manns, Reinhild Klein, Joris Grond, Johannes R. Huizenga, Maarten J. H. Slooff, Karl‐Hermann Meyer Zum Büschenfelde, Peter A. Berg, Chris H. Gips – 1 January 1987 – Antimitochondrial antibodies are markers for primary biliary cirrhosis and probably reflect a specific defect in immunoregulation underlying this disease. Antimitochondrial antibodies and their primary biliary cirrhosis‐specific subtypes were tested before and up to 6 years after orthotopic liver transplantation.

Hepadnaviruses and retroviruses share genome homology and features of replication

William S. Robinson, Roger H. Miller, Patricia L. Marion – 1 January 1987 – The hepadnavirus (1–3) family includes hepatitis B virus (HBV), woodchuck hepatitis virus (WHV) (4), ground squirrel hepatitis virus (GSHV) (5) and duck hepatitis B virus (DHBV) (6). These viruses share unique ultrastructural, molecular and biological features. HBV has great medical importance in many parts of the world. More important numerically than acute hepatitis B in high prevalence geographic regions is the liver disease associated with chronic infection.

The pAS vector system and its application to heterologous gene expression in escherichia coli

Allan R. Shatzman, Martin Rosenberg – 1 January 1987 – There are numerous proteins of biological interest which cannot be obtained from natural sources in quantities sufficient for detailed biochemical and physical analysis. The limited bioavailability of these molecules has made it impossible to consider their potential utilization as either pharmacological agents and/or targets. One solution to this problem has been the development of recombinant vector systems which are designed to achieve efficient expression of cloned genes in a variety of biological systems.

Predictive value of random sample urine bile acids corrected by creatinine in liver disease

Vlado Simko, Shoukry Michael, Robert E. Kelley – 1 January 1987 – Bile acids, in a random sample of urine, discriminated normal controls from liver disease, with a probability similar to fasting plasma bile acids (p < 0.01 and p < 0.001, depending on the analytical technique). A high degree of correlation between urinary and plasma bile acids (up to r = 0.93) was achieved only when the urine flow was corrected by using a urinary bile acids/creatinine ratio but not with urinary bile acids as simple volume concentration.

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