J. Michael Henderson, Steven S. Scott, Alfred H. Merrill, Bettye Hollins, Michael H. Kutner – 1 April 1989 – This study evaluated the effect of daily oral pyridoxine supplementation in patients with cirrhosis. Eight subjects were treated with 25 mg of pyridoxine for 28 days. Before and after the supplementation period, B6 status was assessed by measuring fasting plasma vitamer levels and response to a 25 mg oral pyridoxine load. In addition, a 24‐hr urine collection was analyzed during each load study for B6 metabolites.

Kazuo Tarao, Hiroshi Hoshino, Ikuko Motohashi, Kazuto Iimori, Setsuo Tamai, Yoshihiko Ito, Seiichi Takagi, Yubo Oikawa, Shiro Unayama, Takuya Fujiwara, Kunio Odagiri, Toshio Ikeda, Kazuhiro Hayashi, Akira Sakurai, Toshiyuki Uchikoshi – 1 April 1989 – Alcoholic liver fibrosis is a relatively common form of alcoholic liver disease in Japan. It is regarded by some investigators as a prodromal stage of alcoholic liver cirrhosis, but little is known about the volumes of the liver and spleen in this disease state.

Antonio Francavilla, Lorenzo Polimeno, Alfredo Dileo, Michele Barone, Peter Ove, Mona Coetzee, Patricia Eagon, Leonard Makowka, Giovanni Ambrosino, Vincenzo Mazzaferro, Thomas E. Starzl – 1 April 1989 – We have previously shown that changes in estrogen‐hepatocyte interaction occur during liver regeneration. Following 70% hepatectomy, estrogen levels in the blood were elevated, the number of estrogen receptors in the liver was increased and there was an active translocation of estrogen receptors from the cytosol to the nucleus.

William S. Mason, John M. Taylor – 1 April 1989 – The past decade has seen a dramatic increase in the number of approaches available for the study of hepadnavirus and hepatitis delta virus infections. In this review, we have summarized the recent applications of these approaches to the study of virus replication, tissue specificity, liver injury and hepatocellular carcinogenesis.

David Kershenobich, Florence Vargas, Guadalupe Garcia‐Tsao, Ruy Perez Tamayo, Michael Gent, Marcos Rojkind – 1 April 1989

Laurent Combettes, Brigitte Berthon, Michel Claret, Serge Erlinger, M. Sawkat Anwer, Larry R. Engelking, Roger Lester – 1 April 1989

Santiago J. Muñoz, James E. Heubi, William F. Balistreri, Willis C. Maddrey – 1 April 1989 – In contrast to deficiencies of vitamins A, D and K, little is known of the prevalence, clinical manifestations and mechanisms of vitamin E deficiency in adult patients with cholestasis. We measured serum vitamin E levels in 45 patients with primary biliary cirrhosis, 20 with primary sclerosing cholangitis, 9 with cryptogenic cirrhosis and 12 with alcoholic cirrhosis.

Julius Erdstein, Steven Wisebord, Shaindel Y. Mishkin, Seymour Mishkin – 1 April 1989 – Morris hepatoma 44, whose growth is sensitive to thyroid hormones and prolactin, contains specific receptors for these hormones. In the present experiments, male Buffalo rats bearing Morris hepatoma 7787 were studied to determine the effects of several sex steroid hormones. Castration 1 week postimplantation inhibited tumor growth relative to controls (‐53%). Replacement with testosterone propionate (1 mg per day s.c.

Bruce F. Scharschmidt, John R. Lake – 1 April 1989 – An impaired sulfoxidation pathway has been implicated in the pathogenesis of chlorpromazine‐induced hepatotoxicity. Since some patients with chronic chlorpromazine‐induced cholestasis may have features of primary biliary cirrhosis, we studied the ability to sulfoxidate the amino acid analogue S‐carboxymethyl‐cysteine in 44 patients with primary biliary cirrhosis and in two control groups—one without liver disease and one with a variety of liver diseases other than primary biliary cirrhosis.

Sergio Sainz, Germán Soriano, Carlos Guarner, Pere Coll, Francisco Vilardell, Bruce A. Runyon – 1 April 1989