Antonio Francavilla, Lorenzo Polimeno, Alfredo Dileo, Michele Barone, Peter Ove, Mona Coetzee, Patricia Eagon, Leonard Makowka, Giovanni Ambrosino, Vincenzo Mazzaferro, Thomas E. Starzl – 1 April 1989 – We have previously shown that changes in estrogen‐hepatocyte interaction occur during liver regeneration. Following 70% hepatectomy, estrogen levels in the blood were elevated, the number of estrogen receptors in the liver was increased and there was an active translocation of estrogen receptors from the cytosol to the nucleus.

William S. Mason, John M. Taylor – 1 April 1989 – The past decade has seen a dramatic increase in the number of approaches available for the study of hepadnavirus and hepatitis delta virus infections. In this review, we have summarized the recent applications of these approaches to the study of virus replication, tissue specificity, liver injury and hepatocellular carcinogenesis.

David Kershenobich, Florence Vargas, Guadalupe Garcia‐Tsao, Ruy Perez Tamayo, Michael Gent, Marcos Rojkind – 1 April 1989

Laurent Combettes, Brigitte Berthon, Michel Claret, Serge Erlinger, M. Sawkat Anwer, Larry R. Engelking, Roger Lester – 1 April 1989

Santiago J. Muñoz, James E. Heubi, William F. Balistreri, Willis C. Maddrey – 1 April 1989 – In contrast to deficiencies of vitamins A, D and K, little is known of the prevalence, clinical manifestations and mechanisms of vitamin E deficiency in adult patients with cholestasis. We measured serum vitamin E levels in 45 patients with primary biliary cirrhosis, 20 with primary sclerosing cholangitis, 9 with cryptogenic cirrhosis and 12 with alcoholic cirrhosis.

Julius Erdstein, Steven Wisebord, Shaindel Y. Mishkin, Seymour Mishkin – 1 April 1989 – Morris hepatoma 44, whose growth is sensitive to thyroid hormones and prolactin, contains specific receptors for these hormones. In the present experiments, male Buffalo rats bearing Morris hepatoma 7787 were studied to determine the effects of several sex steroid hormones. Castration 1 week postimplantation inhibited tumor growth relative to controls (‐53%). Replacement with testosterone propionate (1 mg per day s.c.

Bruce F. Scharschmidt, John R. Lake – 1 April 1989 – An impaired sulfoxidation pathway has been implicated in the pathogenesis of chlorpromazine‐induced hepatotoxicity. Since some patients with chronic chlorpromazine‐induced cholestasis may have features of primary biliary cirrhosis, we studied the ability to sulfoxidate the amino acid analogue S‐carboxymethyl‐cysteine in 44 patients with primary biliary cirrhosis and in two control groups—one without liver disease and one with a variety of liver diseases other than primary biliary cirrhosis.

Sergio Sainz, Germán Soriano, Carlos Guarner, Pere Coll, Francisco Vilardell, Bruce A. Runyon – 1 April 1989

Craig J. McClain, Donald A. Cohen – 1 March 1989 – Tumor necrosis factor is a cytokine that mediates many of the biologic actions of endotoxin. Recent studies have shown that tumor necrosis factor administration may cause liver injury and that tumor necrosis factor may mediate the lethality of the hepatotoxin galactosamine. One of the most potent inducers of tumor necrosis factor production is endotoxin.

Tse‐Ling Fong, Evangelos A. Akriviadis, Bruce A. Runyon, Telfer B. Reynolds – 1 March 1989 – The purposes of this study were (a) to measure serially ascitic fluid polymorphonuclear cell response in treated spontaneous bacterial peritonitis and (b) to determine whether an ascitic fluid polymorphonuclear cell count of less than 250 per mm3 on serial paracenteses was a satisfactory endpoint for antibiotic therapy.