Hervé Emonard, Jean‐Alexis Grimaud – 1 July 1989 – In schistosomiasis mansoni, eggs trapped in portal venules of the liver induce a granulomatous inflammatory reaction and subsequently fibrosis. Upon specific schistosomicidal treatment, however, fibrosis undergoes a marked reversal. The features of this process as regards collagen metabolism were examined in mice using praziquantel as the schistosomicidal drug, which was given 68 days after infection.

Caroline R. Taylor – 1 July 1989 – The accuracy of ultrasound assessment of portal vein patency has been defined by comparing it with the results of arterial portography in 115 cases. The accuracy of arterial portography was confirmed in 21 cases where orthotopic liver transplantation was performed and used as a “benchmark” against which to assess the ultrasound findings. Ultrasound correctly assessed portal vein patency in 87.5% of patients. It was more accurate in assessing patency (90%) than occlusion (68%).

Franklin M. Klion – 1 July 1989

1 July 1989

1 July 1989

E. Rolland Dickson, Patricia M. Grambsch, Thomas R. Fleming, Lloyd D. Fisher, Alice Langworthy – 1 July 1989 – The ideal mathematical model for predicting survival for individual patients with primary biliary cirrhosis should be based on a small number of inexpensive, noninvasive measurements that are universally available. Such a model would be useful in medical management by aiding in the selection of patients for and timing of orthotopic liver transplantation. This paper describes the development, testing and use of a mathematical model for predicting survival.

Werner‐J. Mayet, Georg Hess, Guido Gerken, Siegbert Rossol, Rita Voth, Michael Manns, Karl‐Hermann Meyer ZumBüschenfelde – 1 July 1989 – Recombinant human α‐interferon is now under intensive investigation as therapy for chronic Type B hepatitis. Recent reports have suggested that prolonged α‐interferon therapy may induce autoimmune reactions. We have evaluated the problem of autoimmunity related to α‐interferon therapy by testing for 15 different antibodies in the sera of 31 patients treated with α‐interferon.

Philippe Marteau, François Ballet, Olivier Chazouillères, Yves Chrétien, Colette Rey, Danielle Petit, Raoul Poupon – 1 June 1989 – We studied the effects of a series of vasodilators on intrahepatic vascular resistance of isolated perfused cirrhotic rat livers in basal conditions and during norepinephrine‐induced vasoconstriction. Cirrhosis was induced by repeated intraperitoneal injections of carbon tetrachloride.

Andres T. Blei – 1 June 1989

Alastair D. Burt, Dina Tiniakos, Roderick N. M. MacSween, Maureen R. Griffiths, Eddie Wisse, Julia M. Polak – 1 June 1989 – The distribution of adrenergic nerves in guinea pig and rat liver was studied by the immunolocalization of fibers containing tyrosine hydroxylase and dopamine β‐hydroxylase, enzymes involved in the synthesis of catecholamines. In both species, adrenergic fibers were identified within portal tracts, often in close proximity hepatic artery branches.