Vitamin E deficiency in primary biliary cirrhosis: Gastrointestinal malabsorption, frequency and relationship to other lipid‐soluble vitamins

Santiago J. Muñoz, James E. Heubi, William F. Balistreri, Willis C. Maddrey – 1 April 1989 – In contrast to deficiencies of vitamins A, D and K, little is known of the prevalence, clinical manifestations and mechanisms of vitamin E deficiency in adult patients with cholestasis. We measured serum vitamin E levels in 45 patients with primary biliary cirrhosis, 20 with primary sclerosing cholangitis, 9 with cryptogenic cirrhosis and 12 with alcoholic cirrhosis.

The effect of several sex steroid hormones on the growth rate of three morris hepatoma tumor lines

Julius Erdstein, Steven Wisebord, Shaindel Y. Mishkin, Seymour Mishkin – 1 April 1989 – Morris hepatoma 44, whose growth is sensitive to thyroid hormones and prolactin, contains specific receptors for these hormones. In the present experiments, male Buffalo rats bearing Morris hepatoma 7787 were studied to determine the effects of several sex steroid hormones. Castration 1 week postimplantation inhibited tumor growth relative to controls (‐53%). Replacement with testosterone propionate (1 mg per day s.c.

Impaired sulfoxidation in patients with primary biliary cirrhosis

Bruce F. Scharschmidt, John R. Lake – 1 April 1989 – An impaired sulfoxidation pathway has been implicated in the pathogenesis of chlorpromazine‐induced hepatotoxicity. Since some patients with chronic chlorpromazine‐induced cholestasis may have features of primary biliary cirrhosis, we studied the ability to sulfoxidate the amino acid analogue S‐carboxymethyl‐cysteine in 44 patients with primary biliary cirrhosis and in two control groups—one without liver disease and one with a variety of liver diseases other than primary biliary cirrhosis.

Increased tumor necrosis factor production by monocytes in alcoholic hepatitis

Craig J. McClain, Donald A. Cohen – 1 March 1989 – Tumor necrosis factor is a cytokine that mediates many of the biologic actions of endotoxin. Recent studies have shown that tumor necrosis factor administration may cause liver injury and that tumor necrosis factor may mediate the lethality of the hepatotoxin galactosamine. One of the most potent inducers of tumor necrosis factor production is endotoxin.

Polymorphonuclear cell count response and duration of antibiotic therapy in spontaneous bacterial peritonitis

Tse‐Ling Fong, Evangelos A. Akriviadis, Bruce A. Runyon, Telfer B. Reynolds – 1 March 1989 – The purposes of this study were (a) to measure serially ascitic fluid polymorphonuclear cell response in treated spontaneous bacterial peritonitis and (b) to determine whether an ascitic fluid polymorphonuclear cell count of less than 250 per mm3 on serial paracenteses was a satisfactory endpoint for antibiotic therapy.

Enzyme profile of rat bile ductular epithelial cells in reference to the resistance phenotype in hepatocarcinogenesis

Georg A. Mathis, Sandra A. Walls, Paul D'Amico, Thomas F. Gengo, Alphonse E. Sirica – 1 March 1989 – An extensive bile ductular cell hyperplasia with the formation of well‐differentiated bile ductules is the most prominent feature of rat liver at 6 to 15 weeks after bile duct ligation. We have improved our previous cell isolation procedure and are now routinely able to obtain from such livers high yields of viable bile ductular epithelial cells.

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