Warren D. Lo, Steven R. Ennis, Gary W. Goldstein, David L. McNeely, A. Lorris Betz – 1 May 1987 – The role of changes in blood‐brain barrier permeability in the pathogenesis of hepatic encephalopathy remains uncertain. To test the hypothesis that brain microvessel permeability is nonselectively increased in hepatic encephalopathy we measured the blood‐brain barrier permeability‐surface area product in rats with acute liver failure induced by intraperitoneal injection of galactosamine.

Josep Terés, Josep M. Bordas, Dolores Bravo, Josep Visa, Luis Grande, Juan Carlos Garcia‐Valdecasas, Cristóbal Pera, Joan Rodés – 1 May 1987 – One hundred and twelve consecutive Child Class A and B cirrhotic patients were included in a prospective controlled trial aimed at investigating the efficacy and safety of endoscopic sclerotherapy vs. distal splenorenal shunt in the elective treatment of hemorrhage from esophagogastric varices. Fifty‐seven patients were randomly allocated to splenorenal shunt and 55 to endoscopic sclerotherapy.

David G. Oelberg, William P. Dubinsky, Jeffrey W. Sackman, Leslie B. Wang, Eugene W. Adcock, Roger Lester – 1 March 1987 – At high concentrations, bile salts induce hemolysis by comicellization of lipid components of the cell membrane. However, bile salts are also associated with hemolysis at lower concentrations by mechanisms which have not been characterized.

Syoji Kuroki, Erwin H. Mosbach, Richard J. Stenger, Bertram I. Cohen, Charles K. McSherry – 1 March 1987 – The metabolism and effect on biliary lipids of a new bile acid analog, 7‐methyl‐deoxycholic acid, were studied and compared with those of deoxycholic acid in the hamster. 14C‐Labeled 7‐methyl‐deoxycholic acid and deoxycholic acid were administered intravenously or intraduodenally to bile fistula hamsters at 1.0 or 4.0 μmoles per min·kg, and hepatic bile was analyzed for radioactive metabolites and biliary lipid outputs.

B. A. Runyon – 1 March 1987

Robert L. Carithers – 1 March 1987

Keith S. Henley – 1 March 1987

J. P. Colombo – 1 March 1987 – Portacaval shunt (PCS) operations were performed on male inbred SD rats. The activity of liver γ‐glutamyltranspeptidase (GGT) increased a few days after the operation and remained high after several months. However, the activity was only present in periportal areas of liver lobules and was mainly restricted to the endothelial lining cells of periportal blood vessels. Phenobarbital sodium (CAS: 57–03–7) administration did not change the distribution of GGT.

David F. Ransohoff – 1 March 1987 – We investigated the natural history of cholelithiasis in 59 samples of stones from the gallbladder or common bile duct in 15 patients, using as a tracer for the timing of stone formation the 14C released into the environment during nuclear weapons testing. The ages of the stones were correlated with the dates of onset of symptoms and with other clinical data.

L. Frederick Fenster, Harold O. Conn – 1 March 1987 – A young man with chronic active hepatitis was heavily sedated during an attempted transjugular liver biopsy. The procedure was abandoned after 3 h and an immediate percutaneous liver biopsy was performed. This showed features of chronic active hepatitis but, in addition, groups of poly‐morphonuclear leukocytes in the parenchyma. These were similar to the operation associated neutrophils encountered in liver biopsies taken during the course of abdominal surgery.