G. A. Morali, L. M. Blendis – 1 September 1990 – The pathogenesis of ascites formation in cirrhosis is uncertain. It is still under debate whether the effective blood volume is reduced (underfilling theory) or whether the intravascular compartment is expanded (overflow theory). This problem has not yet been solved because of insufficient tools for measuring the central blood volume. We have developed a method that enables us to determine directly the central blood volume, i.e., the blood volume in the heart cavities, lungs, and central arterial tree.

Yang O. Huh – 1 September 1990

Leonard C. Warner, Peter J. Campbell, Gilles A. Morali, Alexander G. Logan, Karl L. Skorecki, Laurence M. Blendis – 1 September 1990 – Despite intensive investigation, the pathogenesis of sodium retention in patients with chronic liver disease is not fully known. We have studied 19 chronic liver disease patients, 13 without (group 1) and six with (group 2) histories of clinical sodium retention (ascites or edema) by varying dietary sodium intake.

Dominique Vuitton – 1 September 1990 – The efficacy of albendazole (50 mg/kg/d), mebendazole (50 mg/kg/d) and praziquantel (500 mg/kg/d) against established intraperitoneal infections of Echinococcus multilocularis in gerbils was compared by monitoring parasite weight and making ultrastructural observations on treated and untreated material. Praziquantel was the most active protoscolicidal agent, reducing protoscolex viability to <2%, although it did not inhibit cyst growth.

Telfer B. Reynolds – 1 September 1990 – Study Objective: To determine the efficacy of a corticosteroid in reducing the short‐term mortality of patients with 8evere alcoholic hepatitis.

David A. Gremse, Hassan H. A‐Kader, Timothy J. Schroeder, William F. Balistreri – 1 September 1990 – Lidocaine, an aminoethylamide, undergoes deethylation in the liver after intravenous injection, resulting in the formation of monoethylglycinexylidide. Serum monoethylglycinexylidide concentration can be measured by a simple, rapid fluorescent polarization immunoassay. We sought to determine whether lidocaine metabolism, as indicated by monoethylglycinexylidide formation, could be used as a quantitative index of hepatic function.

Scott L. Friedman – 1 September 1990

David H. Van Thiel, Rudolf E. Stauber, Judith S. Gavaler, Elaine Rosenblum – 1 September 1990 – Animals with end‐to‐side portacaval shunts and sham‐operated animals, wherein the body weight and liver weight of the animals varied spontaneously over a considerable range, were studied. The relationships between hepatic androgen‐ and estrogen‐receptor content, serum testosterone and estradiol levels and hepatic mass were characterized. Animals with portacaval shunts were smaller than those without shunts. Moreover, they had reduced serum levels of testosterone and estradiol.

Hidekazu Tsukamoto, Karl Gaal, Samuel W. French – 1 September 1990

Christine Silvain, Eric Fort, Pierre Ingrand, Michel Beauchant, Jorge E. Valenzuela, Timothy Schubert, James Posillico, Loren Laine – 1 September 1990