Hepatocyte enlargement and portal hypertension
Hector Orrego, Laurence M. Blendis, Yedy Israel – 1 December 1990
Flexible sigmoidoscopy. Edited by M. Schapiro and G. A. Lehman, 227 pp. Baltimore, MD: Williams & Wilkins, 1990. $45.00
Fredric Regenstein – 1 December 1990
Hepatology: What a difference a decade makes
Steven Schenker, S. Angela Khan – 1 December 1990
Primary culture of adult rat hepatocytes after 48‐hour preservation of the liver with cold UW solution
Claire Guyomard, Christophe Chesne, Bernard Meunier, Alain Fautrel, Catherine Clerc, Fabrice Morel, Maryvonne Rissel, Jean‐Pierre Campion, André Guillouzo – 1 December 1990 – Rat livers were perfused and stored for 48 hr in cold University of Wisconsin solution before dissociation by the two‐step collagenase method. At that time, glycogen content was significantly reduced, but no obvious changes in albumin, β‐actin and aldolase B mRNAs and in glutathione levels were observed. Enzymatic perfusion yielded 280 ± 30 × 106 viable hepatocytes vs.
Influence of hepatitis delta virus replication in the presence of hepatitis B virus DNA in peripheral blood mononuclear cells
Gloria Moraleda, Javier Bartolomé, Maria Gracia Martinez, Juan Carlos Porres, Vicente Carreño – 1 December 1990 – The presence of hepatitis B virus DNA was studied in peripheral blood mononuclear cell samples from 259 HBsAg carriers (229 anti‐hepatitis delta negative, 30 anti‐hepatitis delta positive), 16 anti‐HBc—positive HBsAg‐negative patients and 30 patients without hepatitis B virus markers.
Factors influencing response to interferon in chronic hepatitis B: Implications for Asian and western populations
Robert P. Perrillo – 1 December 1990
Hepatology Elsewhere: Au revoir
Harold O. Conn, Marilyn B. Conn – 1 December 1990
Attenuation of alcohol‐induced hepatic fibrosis by polyunsaturated lecithin
Charles S. Lieber, Leonore M. Decarli, Ki M. Mak, Cho‐Il Kim, Maria A. Leo – 1 December 1990 – Characteristic features of alcoholic liver injury include fibrosis and striking membrane alterations, with associated phospholipid changes. To offset some of these abnormalities, a 10‐yr study was conducted in baboons: 12 animals (eight females, four males) were fed a liquid diet supplemented with polyunsaturated lecithin (4.1 mg/kcal) for up to 8 yr, with either ethanol (50% of total energy) or isocaloric carbohydrate.
Restoration of liver function in gunn rats without immunosuppression using transplanted microencapsulated hepatocytes
Vivek Dixit, Ruth Darvasi, Marika Arthur, Maria Brezina, Klaus Lewin, Gary Gitnick – 1 December 1990 – Microencapsulation of cells within synthetic semipermeable membranes is a novel technique that enables the transplantation of cell cultures without the need for immunosuppression. We have previously shown that transplanted isolated encapsulated hepatocytes can provide sufficient short‐term metabolic support to improve the survival of animals with galactosamine‐induced fulminant hepatic failure.
Site‐directed mutagenesis of lysine within the immunodominant autoepitope of PDC‐E2
Patrick S. C. Leung, Takashi Iwayama, Ross L. Coppel, M. Eric Gershwin – 1 December 1990 – The major autoantigens of PBC have been identified as the four closely related mitochondrial enzymes PDC‐E2, BCKD‐E2 OGDC‐E2 and protein X. A major structural similarity of these enzymes is the presence of one or more lipoyl domains. The immunodominant epitope of each autoantigen has either been postulated or been demonstrated to be located within the lipoate binding region. However, it is not clear whether the binding of lipoic acid to the epitope is necessary for autoantibody recognition.