Omeprazole and aryl hydrocarbon hydroxylases: Should we be worried?

J. C. Kolars, D. K. Turgeon, P. B. Watkins – 1 January 1991 – Diaz and colleagues have carefully studied the effects of omeprazole on the expression of cytochrome P‐450 in primary cultures of human hepatocytes. When omeprazole was added to the culture medium in varying concentrations, there was an increase in P‐450IA2 protein and mRNA concentrations, an increase in de novo synthesis of P‐450IA2 protein, and an increase in microsomal catalytic activities characteristic of P‐450IA2 (phenacetin deethylase and acetanilide hydroxylase).

Detection of hepatitis B virus DNA in paraffin‐embedded liver tissues in chronic hepatitis B or non‐A, non‐B hepatitis using the polymerase chain reaction

Michiko Shindo, Tadao Okuno, Ken Arai, Masayuki Matsumoto, Makoto Takeda, Kei Kashima, Mamoru Shimada, Yoshiaki Fujiwara, Yoshihiro Sokawa – 1 January 1991 – We developed a polymerase chain reaction assay for the direct detection of hepatitis B virus in paraffinembedded liver tissue and applied this assay to determine whether hepatitis B virus DNA exists in livers with chronic hepatitis non‐A, non‐B.

Kupffer cell activation and endothelial cell damage after storage of rat livers: Effects of reperfusion

Jane C. Caldwell‐Kenkel, Robert T. Currin, Yukio Tanaka, Ronald G. Thurman, John J. Lemasters – 1 January 1991 – Reperfusion injury characterized by loss of endothelial cell viability occurs after cold ischemic storage of livers for transplantation surgery. Here, ultrastructural changes in stored rat livers were examined by scanning and transmission electron microscopy. With increasing times of storage in Euro‐Collins solution (4 to 24 hr) followed by 15 min of reperfusion at 37° C, a sequence of structural alterations was observed involving endothelial and Kupffer cells.

Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis

Susan E. Davies, Bernard C. Portmann, John G. O′grady, Peter M. Aldis, Kanchan Chaggar, Graeme J. M. Alexander, Roger Williams – 1 January 1991 – Long‐term follow‐up of 27 patients with hepatitis B virus—related chronic liver disease treated by transplantation showed that 23 had hepatitis B virus recurrence. In 13 patients late changes in the grafts were similar to those described in other series: minor abnormalities in five cases, chronic active hepatitis in five cases and non‐hepatitis B virus—related graft dysfunction in three cases. Three patients had incomplete histological follow‐up.

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