Antoine Hadengue, Richard Moreau, Yannick Bacq, Christophe Gaudin, Alain Braillon, Didier Lebrec – 1 January 1991 – We studied the effects of fenoldopam, a selective dopamine DA1 agonist on systemic and splanchnic hemodynamics, renal blood flow and sodium excretion in 12 patients with alcoholic cirrhosis and ascites. Hepatic, azygos and renal veins were catheterized before and after intravenous administration of fenoldopam, 0.05 μg/kg/min for 1 hr and increased to 0.1 μg/kg/min for another hour.

Paul D. Berk – 1 January 1991

J. C. Kolars, D. K. Turgeon, P. B. Watkins – 1 January 1991 – Diaz and colleagues have carefully studied the effects of omeprazole on the expression of cytochrome P‐450 in primary cultures of human hepatocytes. When omeprazole was added to the culture medium in varying concentrations, there was an increase in P‐450IA2 protein and mRNA concentrations, an increase in de novo synthesis of P‐450IA2 protein, and an increase in microsomal catalytic activities characteristic of P‐450IA2 (phenacetin deethylase and acetanilide hydroxylase).

1 January 1991

Michiko Shindo, Tadao Okuno, Ken Arai, Masayuki Matsumoto, Makoto Takeda, Kei Kashima, Mamoru Shimada, Yoshiaki Fujiwara, Yoshihiro Sokawa – 1 January 1991 – We developed a polymerase chain reaction assay for the direct detection of hepatitis B virus in paraffinembedded liver tissue and applied this assay to determine whether hepatitis B virus DNA exists in livers with chronic hepatitis non‐A, non‐B.

James S. Malter, Michael A. Gerber – 1 January 1991

Masako Wakabayashi, Arvin E. Robinson – 1 January 1991

Manuel Rodriguez, Ana Martinez, Pedro Sala, Sabino Riestra, Adolfo Suárez, Luis Rodrigo, Maria Buti – 1 January 1991

1 January 1991

Jane C. Caldwell‐Kenkel, Robert T. Currin, Yukio Tanaka, Ronald G. Thurman, John J. Lemasters – 1 January 1991 – Reperfusion injury characterized by loss of endothelial cell viability occurs after cold ischemic storage of livers for transplantation surgery. Here, ultrastructural changes in stored rat livers were examined by scanning and transmission electron microscopy. With increasing times of storage in Euro‐Collins solution (4 to 24 hr) followed by 15 min of reperfusion at 37° C, a sequence of structural alterations was observed involving endothelial and Kupffer cells.