Specificity of the hepatocyte Na+ ‐dependent taurocholate transporter: Influence of side chain length and charge
William G. M. Hardison, Victor L. Heasley, Dale F. Shellhamer – 1 January 1991 – Trihydroxy bile acids with differing nonsterol chain length and charge were synthesized to define the effect of these parameters on the ability to competitively inhibit the Na+‐dependent uptake of 14C taurocholate into isolated rat hepatocytes. Compounds with long side chains (≥ 0.8 nm) beyond carbon‐17 of the sterol nucleus and carrying a negative charge or no charge were potent inhibitors. Introduction of a positive charge into the side chain weakened inhibition.