Robert G. Paul, Stanford T. Roodman, Carolyn R. Campbell, Carol J. Bodicky, Robert P. Perrillo – 1 May 1991 – HLA class I antigen expression on peripheral blood mononuclear cells was evaluated by flow cytometry in 21 HBeAg‐positive patients with chronic hepatitis B. Measurements were made before, during or after treatment with recombinant interferon‐α‐2b, either given alone or after a 6 wk course of prednisone.

Karl E. Anderson, Reneé B. McCleery, Elliot S. Vesell, Florence F. Vickers, Attallah Kappas – 1 May 1991 – This study compared the effects of diet and cimetidine on theophylline metabolism and examined interactions between these effects. Twelve men received a high‐protein diet for 15 days and at another time a high‐carbohydrate diet also for 15 days. Cimetidine, 800 mg daily at bedtime, was administered on days 10 through 15 of each dietary period. Theophylline metabolism was studied after the administration of a single intravenous 3 mg/kg dose on days 8 and 15 of each dietary period.

Sanjiv Chopra – 1 May 1991

Anastacio M. Hoyumpa, Steven Schenker – 1 April 1991

Raymond S. Koff, I. David Shocket – 1 April 1991

Paul Martin, Santiago J. Muñoz, Adrian M. Di Bisceglie, Raphael Rubin, Jeanne G. Waggoner, Vincent T. Armenti, Michael J. Moritiz, Bruce E. Jarrell, Willis C. Maddrey – 1 April 1991 – Identification of the hepatitis C virus–the main cause of posttransfusion and sporadic non‐A, non‐B hepatitis–and the development of a diagnostic serological test have allowed us to study possible recurrence of this type of hepatitis after liver transplantation. Six of 34 consecutive transplant recipients were found to have had antibodies to hepatitis C before transplantation.

David Y. Mitchell, Dennis R. Petersen – 1 April 1991 – The hepatic oxidation of ethanol has been demonstrated to cause peroxidation of cellular membranes, resulting in the production of aldehydes that are substrates for hepatic aldehyde dehydrogenases. It was the purpose of this study to evaluate the cooxidation of the lipid peroxidation product, trans‐4‐hydroxy‐2‐nonenal, and acetaldehyde by high‐affinity mitochondrial aldehyde dehydrogenase, which is of prominent importance in the oxidation of ethanol‐derived acetaldehyde.

Jorge J. Gumucio, Jonathan D. Kaunitz – 1 April 1991 – The “liver” isoform of the facilitated diffusion glucose transporter is expressed predominantly in liver, intestine, kidney, and pancreatic islet α‐cells. The apparent molecular mass of the transporter in liver, kidney, and intestine is different, as detected by Western blot analysis of membrane proteins using antipeptide antibodies.

Jorge J. Gumucio, Bahri Bilir, Jorge J. Gumucio – 1 April 1991 – The “erythroid/brain” glucose transporter (GT) isoform is expressed only in a subset of hepatocytes, those forming the first row around the terminal hepatic venules, while the “liver” GT is expressed in all hepatocytes. After 3 d of starvation, a three‐ to fourfold elevation of expression of the erythroid/brain GT mRNA and protein is detected in the liver as a whole; this correlates with the expression of this GT in more hepatocytes, those forming the first three to four rows around the hepatic venules.

Jorge J. Gumucio, Robert P. Perillo – 1 April 1991 – To identify previously unrecognized sources for acquiring acute hepatitis B and non‐A, non‐B (NANB) hepatitis, we interviewed patients with these types of hepatitis who were reported to two county health departments in the United States and matched control subjects for known and potential risk factors for acquiring hepatitis. Of 218 patients with hepatitis B and 140 patients with NANB hepatitis, 46% and 53%, respectively, had no commonly recognized source for infection.