David Y. Mitchell, Dennis R. Petersen – 1 April 1991 – The hepatic oxidation of ethanol has been demonstrated to cause peroxidation of cellular membranes, resulting in the production of aldehydes that are substrates for hepatic aldehyde dehydrogenases. It was the purpose of this study to evaluate the cooxidation of the lipid peroxidation product, trans‐4‐hydroxy‐2‐nonenal, and acetaldehyde by high‐affinity mitochondrial aldehyde dehydrogenase, which is of prominent importance in the oxidation of ethanol‐derived acetaldehyde.

Paul Martin, Santiago J. Muñoz, Adrian M. Di Bisceglie, Raphael Rubin, Jeanne G. Waggoner, Vincent T. Armenti, Michael J. Moritiz, Bruce E. Jarrell, Willis C. Maddrey – 1 April 1991 – Identification of the hepatitis C virus–the main cause of posttransfusion and sporadic non‐A, non‐B hepatitis–and the development of a diagnostic serological test have allowed us to study possible recurrence of this type of hepatitis after liver transplantation. Six of 34 consecutive transplant recipients were found to have had antibodies to hepatitis C before transplantation.

Raymond S. Koff, I. David Shocket – 1 April 1991

Anastacio M. Hoyumpa, Steven Schenker – 1 April 1991

Jorge Cerbón‐Ambriz, Jorge Cerbón‐Solórzano, Marcos Rojkind – 1 March 1991 – Previous work has shown that lactic acid, and to a lesser extent pyruvic acid, is able to increase collagen synthesis significantly in liver slices of CCl4‐treated rats but not normal rats. The purpose of this report is to document which cells in the cirrhotic liver are responsible for the lactate‐stimulated increase in collagen synthesis.

Shelley P. M. Fussey, J. Gordon Lindsay, Christopher Fuller, Richard N. Perham, Susan Dale, Oliver F. W. James, Margaret F. Bassendine, Stephen J. Yeaman – 1 March 1991 – Six components of the mammalian 2‐oxo acid dehydrogenase complexes have previously been identified as M2 autoantigens in primary biliary cirrhosis. In this report, we present data showing that both polypeptidespecific and cross‐reacting antibodies are present in patients' sera. Antibodies reacting with E2 of the pyruvate dehydrogenase complex cross‐react with protein X but not with any other mammalian antigen.

Jorge J. Gumucio, Peter F. Malet – 1 March 1991 – Endoscopic intra abdominal surgery yet routinely used for gynecologic operations can be extended for performing cholecystectomy in uncomplicated cholelithiasis.

Robert F. Speck, Bernhard H. Lauterburg – 1 March 1991 – Recent observations suggest that products of nonparenchymal liver cells such as eicosanoids and cytokines might play a role in the expression of liver injury after administration of acetaminophen and other noxious agents. We therefore investigated the effect of a fish oil diet, which results in the generation of eicosanoids with altered biological properties and suppresses the production of certain cytokines on acetaminophen hepatotoxicity.

Wolfgang Hagmann, Iris Kaiser, Barbara A. Jakschik – 1 March 1991 – The ability of livers to produce endogenous leukotrienes after immunological stimulation was tested with organs from rats and guinea pigs. Passive sensitization of rats in vivo with monoclonal murine antidinitrophenol‐IgE before antigen challenge in the isolated perfused liver system elicited a rapid hepatic production and biliary excretion of leukotrienes as judged by radioimmunoassay after separation of individual leukotrienes by high‐performance liquid chromatography.

1 March 1991