IgA triggers tumor necrosis factor α secretion by monocytes: A study in normal subjects and patients with alcoholic cirrhosis
Jacques Devière, Jean‐Pierre Vaerman, Jean Content, Chantal Denys, Liliane Schandene, Paul Vandenbussche, Yves Sibille, Etienne Dupont – 1 April 1991 – Under endotoxin‐free conditions, peripheral blood mononuclear cells and purified monocytes isolated from healthy control subjects and patients with alcoholic cirrhosis disclose elevated tumor necrosis factor α messenger RNA level and produce tumor necrosis factor α in response to stimulation by either soluble polymeric IgA or monomeric IgA bound to the surface of culture dishes but not by soluble monomeric IgA.