Effects of interferon on intrahepatic human leukocyte antigens and lymphocyte subsets in patients with chronic hepatitis B and C

Takuro Hayata, Yoshiyuki Nakano, Kaname Yoshizawa, Takeshi Sodeyama, Kendo Kiyosawa – 1 June 1991 – We investigated the effects of interferon therapy on hepatocyte human leukocyte antigen class I and class II antigen expression and intrahepatic lymphocyte subsets in patients with chronic viral hepatitis B (n = 11) and C (n = 10). Interferon‐α was administered intramuscularly in doses ranging from 3 to 18 million international units daily for 4 wk.

Hepatic fibrosis and cirrhosis after chronic administration of alcohol and “low‐dose” carbon tetrachloride vapor in the rat

Pauline de la M. Hall, John L. Plummer, Anthony H. Ilsley, Michael J. Cousins – 1 May 1991 – Rats were exposed to carbon tetrachloride vapor, 5 days/wk, 6 hr/day, for periods of 5 or 10 wk at a concentration that by itself caused only fatty change with minimal liver cell necrosis and no fibrosis. The same carbon tetrachloride exposure when given in association with chronic alcohol feeding resulted in extensive hepatic fibrosis at 5 wk and established micronodular cirrhosis at 10 wk.

Bile salts stimulate glycoprotein release by guinea pig gallbladder in vitro

Daniel P. O'Leary, Francis E. Murray, Bradley S. Turner, J. Thomas Lamont – 1 May 1991 – Alterations in the composition of bile during cholesterol gallstone formation appear to be responsible for increased release of gallbladder mucin, a potent cholesterol nucleating agent. We investigated the effects of bile salts on release of radiolabeled glycoproteins by explants of guinea pig gallbladder in organ culture.

Direct evidence for cytotoxicity associated with expression of hepatitis delta virus antigen

Susan M. Cole, Eric J. Gowans, Thomas B. Macnaughton, Pauline De La M. Hall, Christopher J. Burrell – 1 May 1991 – It has been postulated that hepatocyte injury resulting from infection with hepatitis D virus may be caused by a direct virus cytotoxicity in contrast to immune‐mediated injury associated with hepatitis B virus. We have transfected HeLa and HepG2 continuous cell lines with a recombinant plasmid containing the hepatitis D antigen gene under the inducible control of the human metallothionein promoter.

Non‐Hodgkin's lymphoma presenting as a primary tumor of the liver: Presentation, diagnosis and outcome in eight patients

Jean‐Yves Scoazec, Claude Degott, Nicole Brousse, Janine Barge, Georges Molas, François Potet, Jean‐Pierre Benhamou – 1 May 1991 – We report the diagnostic, prognostic and therapeutic features of non‐Hodgkin's lymphoma in eight patients in whom the disease was seen as a primary tumor of the liver.

Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial

Harold O. Conn, Norman D. Grace, Jaime Bosch, Roberto J. Groszmann, Joan Rodés, Steven C. Wright, Daniel S. Matloff, Guadalupe Garcia‐Tsao, Rosemarie L. Fisher, Miguel Navasa, Steven J. Drewniak, Colin E. Atterbury, Jose M. Bordas, Emanuel Lerner, Christina Bramante – 1 May 1991 – To assess the effectiveness of propranolol in the prevention of initial variceal hemorrhage, a doubleblind, randomized trial was carried out in three centers.

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