Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration
Pamela M. Lindroos, Reza Zarnegar, George K. Michalopoulos – 1 April 1991 – An enzyme‐linked immunosorbent assay was used to measure the level of hepatocyte growth factor in rat plasma at various times after two‐thirds partial hepatectomy or CCl4 administration. An initial 17‐fold rise and 13‐fold rise in the level of hepatocyte growth factor was observed 2 hr after partial hepatectomy and CCl4 treatment, respectively, well before the onset of DNA synthesis in the liver.