Kimberly A. Brown, Michael R. Lucey – 1 June 1991 – The effect of successful liver transplantation on menstrual function was assessed by questionnaire in 44 women transplanted for various types of end stage liver disease, acute liver failure or malignant disease. Significant amenorrhoea (>one year) was present in 48% of women with chronic liver disease before transplantation, and was reversed within 10 months of surgery in all but one of the pre‐menopausal patients who had primary amenorrhoea and hypogonadotrophic hypogonadism.

Jens H. Henriksen, Flemming Bendtsen, Thorkild I. A. Sørensen, Carsten Stadeager, Helmer Ring‐Larsen – 1 June 1991

1 June 1991

Takuro Hayata, Yoshiyuki Nakano, Kaname Yoshizawa, Takeshi Sodeyama, Kendo Kiyosawa – 1 June 1991 – We investigated the effects of interferon therapy on hepatocyte human leukocyte antigen class I and class II antigen expression and intrahepatic lymphocyte subsets in patients with chronic viral hepatitis B (n = 11) and C (n = 10). Interferon‐α was administered intramuscularly in doses ranging from 3 to 18 million international units daily for 4 wk.

Miguel Yebra, Felix Lacoma, María Paz Queipo de Llano, María E. Moreno – 1 June 1991

Pauline de la M. Hall, John L. Plummer, Anthony H. Ilsley, Michael J. Cousins – 1 May 1991 – Rats were exposed to carbon tetrachloride vapor, 5 days/wk, 6 hr/day, for periods of 5 or 10 wk at a concentration that by itself caused only fatty change with minimal liver cell necrosis and no fibrosis. The same carbon tetrachloride exposure when given in association with chronic alcohol feeding resulted in extensive hepatic fibrosis at 5 wk and established micronodular cirrhosis at 10 wk.

Daniel P. O'Leary, Francis E. Murray, Bradley S. Turner, J. Thomas Lamont – 1 May 1991 – Alterations in the composition of bile during cholesterol gallstone formation appear to be responsible for increased release of gallbladder mucin, a potent cholesterol nucleating agent. We investigated the effects of bile salts on release of radiolabeled glycoproteins by explants of guinea pig gallbladder in organ culture.

Danilo D. Lasic, Siegfried Walker, Christian J. Bode, K.‐J. Paquet – 1 May 1991

1 May 1991

Susan M. Cole, Eric J. Gowans, Thomas B. Macnaughton, Pauline De La M. Hall, Christopher J. Burrell – 1 May 1991 – It has been postulated that hepatocyte injury resulting from infection with hepatitis D virus may be caused by a direct virus cytotoxicity in contrast to immune‐mediated injury associated with hepatitis B virus. We have transfected HeLa and HepG2 continuous cell lines with a recombinant plasmid containing the hepatitis D antigen gene under the inducible control of the human metallothionein promoter.