José Luis Menéndez, José Antonio Girón, Luis Manzano, Aurelio Garrido, Luis Abreu, Agustin Albillos, Alberto Durántez, Melchor Alvarez‐Mon – 1 October 1992 – There is increasing evidence that primary biliary cirrhosis is associated with an alteration of the immune system. Although the cause remains unknown, it has been suggested that the immune system of patients with primary biliary cirrhosis is involved in the pathogenesis of their disease.

Max C. W. Jebbink, Ad A. M. Masclee, Frank G. H. van der Kleij, Jaap Schipper, Lucio C. Rovati, Jan B. M. J. Jansen, Cornelis B. H. W. Lamers – 1 October 1992 – This study was undertaken to investigate the effect of erythromycin, a motilin agonist with prokinetic activity, on fasting gallbladder volume.

David Carbone – 1 October 1992 – Mutations in the p53 tumour‐suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of neoplasms by 6 months of age.

1 October 1992

Nisen Abuaf, Catherine Johanet, Pascale Chretien, Eric Martini, Emmanuelle Soulier, Syria Laperche, Jean Claude Homberg – 1 October 1992 – An autoantibody to liver cytosol was previously described in childhood autoimmune chronic active hepatitis type 2. The antigen, liver cytosol antigen type 1, was for the first time partially purified using gel filtration and ion exchange chromatography, and it was characterized using immunodiffusion, immunoblot and sodium dodecyl sulfate—polyacrylamide gel electrophoresis analysis of the immunoprecipitate.

Keith S. Henley, Daniel P. Normolle – 1 October 1992

Robert H. Resnick – 1 October 1992

Clara Mandell, Lucia Cesarini, Alberto Piperno, Silvia Fargion, Anna L. Fracanzani, Donatella Barisani, Dario Conte – 1 October 1992 – The relationship of pretreatment serum ferritin and hepatic iron concentration to body iron removed by venesections was evaluated in 33 patients with genetic hemochromatosis. The median values of the three variables considered were 1,950 μg/L (range = 255 to 10,000), 1,175 μg/100 mg dry weight (range = 270 to 4,310) and 10 gm (range = 2 to 41), respectively.

Wei‐Li Hu, Paul A. Chindemi, Erwin Regoeczi – 1 October 1992 – The single oligosaccharide attachment in rat transferrin exhibits marked structural microheterogeneity. In this study we examined whether all microheterogeneous forms of rat transferrin found in plasma are derived from a single organ, such as the liver. To this end we analyzed the glycans of rat transferrin synthesized by the isolated perfused rat liver by a method established earlier for rat transferrin isolated from rat plasma.

Chris J. Dickinson – 1 October 1992 – An outbreak of hepatitis A virus (HAV) infection in a neonatal intensive care unit (NICU) provided the opportunity to examine the duration of HAV excretion in infants and the mechanisms by which HAV epidemics are propagated in NICUs. The outbreak affected 13 NICU infants (20%), 22 NICU nurses (24%), 8 other staff caring for NICU infants, and 4 household contacts; 2 seropositive infants (primary cases) received blood transfusions from a donor with HAV infection.