Tirso Castillo, Dennis R. Koop, Seiichiro Kamimura, George Triadafilopoulos, Hidekazu Tsukamoto – 1 October 1992 – This study investigated the role of cytochrome P‐450 2E1 in enhanced microsomal lipid peroxidation in experimental alcoholic liver disease. We also examined the contribution of this isoform to the increased microsomal injury in alcoholic liver disease caused by carbon tetrachloride—induced or iron‐induced oxidant stress.

Jonathan B. Kruskal, Simon C. Robson, John J. Franks, Ralph E. Kirsch – 1 October 1992 – Patients with liver disease have a variety of coagulation abnormalities. These derangements are of uncertain origin and do not always correlate with disease severity or activity.

Steven R. Martin – 1 October 1992

1 October 1992

Tomihiro Hayakawa, Kenji Katagiri, Makoto Hoshino, Tomio Nakai, Takayuki Ohiwa, Tomoyuki Kumai, Makoto Miyaji, Toshihiko Takeuchi, James Corasanti, James L. Boyer – 1 October 1992 – Papaverine is a nonspecific smooth muscle relaxant and a phosphodiesterase inhibitor. Its effects on biliary excretion of lipids and horseradish peroxidase were investigated in a single‐pass isolated perfused rat liver model. A constant infusion of papaverine (1.6 μmol/min; 40 μmol/L) significantly increased bile flow (microliters per minute per gram of liver) before (2.03 ± 0.09 vs.

Philippe Sogni, Richard Moreau, Masaru Ohsuga, Stephane Cailmail, Frederic Oberti, Antoine Hadengue, Eric Pussard, Didier Lebrec – 1 October 1992 – Because it has been hypothesized that the hyperkinetic circulation in portal hypertension is the result of increased synthesis of nitric oxide, we compared the hemodynamic effects of nitric oxide synthesis—specific agonist (L‐arginine) and antagonist between normal and cirrhotic conscious rats. The dose‐response curves showed that L‐arginine significantly decreased arterial pressure and increased heart rate.

Paul D. Berk – 1 September 1992

Tian‐Jun Huang, Jayanta Roy Chowdhury, Pulak Lahiri, Purna C. Yerneni, Vasudeva R. Bommineni, Irwin M. Arias, Namita Roy Chowdhury – 1 September 1992 – Hepatic bilirubin excretion requires UDP‐glucuronosyltransferase–mediated glucuronidation. Patients with type I Crigler‐Najjar syndrome and mutant rats (Gunn strain) inherit deficiency of UDP‐glucuronyltransferase activity toward bilirubin as an autosomal recessive trait and, as a result, exhibit marked nonhemolytic unconjugated hyperbilirubinemia throughout postnatal life.

J. Michael Henderson, G. Thomas Gilmore, Gregory J. Mackay, John R. Galloway, Thomas F. Dodson, Michael H. Kutner – 1 September 1992 – Liver blood flow and systemic hemodynamics were measured intraoperatively in 34 patients after liver transplantation. Ultrasound transit‐time flow probes measured hepatic arterial and portal venous flow over 10 to 75 min 1 to 3 hr after reperfusion. Cardiac output was measured by thermodilution. Mean cardiac output was 9.5 ± 2.8 L/min; the mean total liver blood flow of 2,091 ± 932 ml/min was 23% ± 11% of cardiac output.

Raymond S. Koff – 1 September 1992